Mesonephric-like adenocarcinoma of the uterine corpus with focal sarcomatous differentiation: A case report

This case report describes a 65-year-old postmenopausal woman diagnosed with primary mesonephric-like adenocarcinoma of the uterine corpus, characterized by focal sarcomatous differentiation and initial misdiagnosis as small cell neuroendocrine carcinoma. The patient presented with asymptomatic lung metastases and underwent chemotherapy followed by modified radical hysterectomy, revealing that the tumor originated in the uterine corpus rather than the cervix despite its extension. Although the disease initially responded to treatment, the patient later developed cerebral metastases, highlighting the aggressive nature and diagnostic challenges associated with this rare malignancy. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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