Extrapulmonary hamartoma

Extrapulmonary hamartoma | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Extrapulmonary hamartoma Shaoqing Huang, Jie Li This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4843533/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 06 Jan, 2025 Read the published version in Journal of Cardiothoracic Surgery → Version 1 posted 34 You are reading this latest preprint version Abstract Pulmonary hamartomas are common. However，extrapulmonary hamartomas are very rare. We treated a patient with a pulmonary nodule at the left lower lobe by uniportal video-assisted thoracoscopic wedge resection, which showed a yellow nodule located on the visceral pleura. Pathology showed that the nodule contained a small amount of cartilage tissue and was diagnosed as hamartoma. Extrapulmonary hamartoma of this morphology has not been previously reported. hamartoma Extrapulmonary hamartoma video-assisted thoracoscopic surgery (VATS) Figures Figure 1 Figure 2 Figure 3 Figure 4 Case presentation A 57-year-old woman was admitted to the hospital due to a pulmonary nodule with symptoms. Computed tomography scan of chest showed an 8mm pulmonary nodule without calcification located at the left lower lobe of the lung（Figure1）, which was fuller than before. Physical examination was normal, tumor markers were normal, and cardiopulmonary function was good. The patient underwent wedge resection of the left lower lobe through uniportal video-assisted thoracoscopic surgery (VATS). Thoracoscopy showed a yellow nodule on the pleural surface（Figure2、3）. The pathological results suggested that it was a hamartoma（Figure4）. The patient recovered well and there was no recurrence after 1 year of follow-up. Discussion Hamartoma is the most common benign tumor of the lung. In general, pulmonary hamartoma is mainly divided into intrapulmonary hamartoma and intratracheal hamartoma. [ 1 ] The chest ct will show calcifications. The main treatments are surgery, endoscopy and laser ablation.[ 2 ] Extrapulmonary hamartoma is very rare, and there are only 4 reports in the available literature. [ 1 , 3 – 5 ] In our case, the extrapulmonary hamartoma was located at pleural surface and the chest ct showed no-calcification. Pathological examination revealed pleural surface nodule exhibiting a high fat content, and a small quantity of cartilage tissue was observed.These pieces of evidence supported for the presence of hamartoma. To date, extrapulmonary hamartomas that fit these several features have not been reported. We treated our patient with surgery and there were no recurrence. Usually, the mediastinal window of chest ct and pathological examination will suggest calcifications of pulmonary hamartoma. Our patient's chest ct did not show calcification, which I suspect is because the hamartoma is composed of a large amount of fat and a small amount of cartilage tissue. In our opinion,this case should be differentiated from lipoma and other hypodense neoplasms. In summary, we present a rare extrapulmonary hamartomas that necessitates differentiation from hypodense neoplasms. Declarations Written informed consent to publish was obtained from the study participants. Ethics approval and consent to participate: Ethics approval and consent was obtained. Consent to Publish declaration: Applicable. Availability of data and materials: (this manuscript does not report data generation or analysis). Competing interests: The authors declare that they have no competing interests. Funding Declaration: This artical Supported by Zhu Xiu shan Talent Project of Ningbo No.2 Hospital(Grant No.2023HMYQ07). Authors’ contributions: Shaoqing Huang wrote the main manuscript text and supported the fund. Jie Li prepared figures. All authors reviewed the manuscript. Informed consent from all subjects for publication of identifying information/images in an online open-access publication under Consent for publication. References Endo T, et al. Extrapulmonary hamartoma. Gen Thorac Cardiovasc Surg. 2011;59(3):209–11. Fan M, Lin Y, Liu L. Multiple pulmonary chondroid hamartoma. J Thorac Oncol. 2014;9(7):1053–4. Tomiyasu M, et al. An intrapulmonary chondromatous hamartoma penetrating the visceral pleura: report of a case. Ann Thorac Cardiovasc Surg. 2002;8(1):42–4. Kaptanoğlu M, et al. Pulmonary hamartoma, a rare presentation. Eur J Cardiothorac Surg. 2001;20(5):1031. Teramoto K, Suzumura Y. Multiple pulmonary hamartomas penetrating the visceral pleura: report of a case. Surg Today. 2007;37(12):1087–9. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 06 Jan, 2025 Read the published version in Journal of Cardiothoracic Surgery → Version 1 posted Editorial decision: Revision requested 19 Nov, 2024 Reviews received at journal 18 Nov, 2024 Reviews received at journal 16 Nov, 2024 Reviews received at journal 13 Nov, 2024 Reviews received at journal 13 Nov, 2024 Reviewers agreed at journal 12 Nov, 2024 Reviews received at journal 12 Nov, 2024 Reviewers agreed at journal 12 Nov, 2024 Reviews received at journal 12 Nov, 2024 Reviews received at journal 11 Nov, 2024 Reviewers agreed at journal 11 Nov, 2024 Reviewers agreed at journal 11 Nov, 2024 Reviewers agreed at journal 09 Nov, 2024 Reviews received at journal 09 Nov, 2024 Reviewers agreed at journal 09 Nov, 2024 Reviewers agreed at journal 08 Nov, 2024 Reviews received at journal 08 Nov, 2024 Reviewers agreed at journal 08 Nov, 2024 Reviews received at journal 07 Nov, 2024 Reviewers agreed at journal 06 Nov, 2024 Reviewers agreed at journal 06 Nov, 2024 Reviewers agreed at journal 06 Nov, 2024 Reviewers agreed at journal 06 Nov, 2024 Reviewers agreed at journal 06 Nov, 2024 Reviewers agreed at journal 06 Nov, 2024 Reviewers agreed at journal 06 Nov, 2024 Reviews received at journal 06 Nov, 2024 Reviewers agreed at journal 06 Nov, 2024 Reviewers agreed at journal 06 Nov, 2024 Reviewers agreed at journal 06 Nov, 2024 Reviewers invited by journal 06 Nov, 2024 Editor assigned by journal 11 Aug, 2024 Submission checks completed at journal 11 Aug, 2024 First submitted to journal 01 Aug, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4843533","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":342419779,"identity":"67096013-27a0-413f-90d5-2daeaa4ef143","order_by":0,"name":"Shaoqing Huang","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA90lEQVRIiWNgGAWjYBACAwh1AIgZGxgY/9nw8PM3kKKFgS1NRnLGAaK1gADbYRuDhgT8Wswlkp89/PLnjjw/e3Lbwy8853kMGA4wfviYg1uL5Yw0c2PZtmeGM3sethvLSNzmMWduYJacuQ2Pw24kmElLNhxm3HAjsU1awuA2j2XDATZmXrxa0r9JS/w5bA/RknCOx+BAAiEtOWaSH9gOJ4K0SH44cIAILWfelEkzth1OBvqlTZqxIZlHcsbBZvx+OZ6+TfLHn8O2/ezpzyR/NtjZ8/M3H/zwEY8WEGDmAVMJMAYoTgkAxh9QLVDGKBgFo2AUjAJUAAC92VmUGBDA4wAAAABJRU5ErkJggg==","orcid":"","institution":"Ningbo No. 2 Hospital","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Shaoqing","middleName":"","lastName":"Huang","suffix":""},{"id":342419780,"identity":"3752869c-e6df-4a11-a8d0-105724c1d6b1","order_by":1,"name":"Jie Li","email":"","orcid":"","institution":"Ningbo No. 2 Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jie","middleName":"","lastName":"Li","suffix":""}],"badges":[],"createdAt":"2024-08-01 16:06:28","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4843533/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4843533/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s13019-024-03304-7","type":"published","date":"2025-01-06T15:57:28+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":66083599,"identity":"fbacf03d-06b6-43fc-b93e-f1047bafad87","added_by":"auto","created_at":"2024-10-07 14:13:04","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":6929507,"visible":true,"origin":"","legend":"\u003cp\u003eComputed tomography scan of chest revealed an 8-mm nodule at the left lower lobe\u003c/p\u003e","description":"","filename":"1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-4843533/v1/b2c127916501e27c3fd82e8a.jpg"},{"id":66083602,"identity":"b16565ec-6ff0-44d8-9d7d-0925b3a149e3","added_by":"auto","created_at":"2024-10-07 14:13:06","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":32093835,"visible":true,"origin":"","legend":"\u003cp\u003eNodule shown on thoracoscopy\u003c/p\u003e","description":"","filename":"2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-4843533/v1/e674a005276f9e85e2825035.jpg"},{"id":66083601,"identity":"1e795821-7ae7-4872-a78b-2736d1ae685a","added_by":"auto","created_at":"2024-10-07 14:13:05","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":26836059,"visible":true,"origin":"","legend":"\u003cp\u003eNodule shown on thoracoscopy\u003c/p\u003e","description":"","filename":"3.jpg","url":"https://assets-eu.researchsquare.com/files/rs-4843533/v1/43dde39772c3ae9990d1061b.jpg"},{"id":66083600,"identity":"cd3d0781-43c5-4603-a5f8-a8f5e8585eff","added_by":"auto","created_at":"2024-10-07 14:13:04","extension":"jpg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":4644496,"visible":true,"origin":"","legend":"\u003cp\u003ePathological examination\u003c/p\u003e","description":"","filename":"4.jpg","url":"https://assets-eu.researchsquare.com/files/rs-4843533/v1/9de9f6b22f81fdae793f21aa.jpg"},{"id":73693923,"identity":"6085be3f-2fe0-4692-8b04-46fe2f599094","added_by":"auto","created_at":"2025-01-13 16:09:30","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":70693929,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4843533/v1/f0f81058-6f02-4e92-a553-4ff6139f47d8.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Extrapulmonary hamartoma","fulltext":[{"header":"Case presentation","content":"\u003cp\u003eA 57-year-old woman was admitted to the hospital due to a pulmonary nodule with symptoms. Computed tomography scan of chest showed an 8mm pulmonary nodule without calcification located at the left lower lobe of the lung（Figure1）, which was fuller than before. Physical examination was normal, tumor markers were normal, and cardiopulmonary function was good. The patient underwent wedge resection of the left lower lobe through uniportal video-assisted thoracoscopic surgery (VATS). Thoracoscopy showed a yellow nodule on the pleural surface（Figure2、3）. The pathological results suggested that it was a hamartoma（Figure4）. The patient recovered well and there was no recurrence after 1 year of follow-up.\u003c/p\u003e"},{"header":"Discussion","content":" \u003cp\u003eHamartoma is the most common benign tumor of the lung. In general, pulmonary hamartoma is mainly divided into intrapulmonary hamartoma and intratracheal hamartoma. [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e] The chest ct will show calcifications. The main treatments are surgery, endoscopy and laser ablation.[\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e] Extrapulmonary hamartoma is very rare, and there are only 4 reports in the available literature. [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e, \u003cspan additionalcitationids=\"CR4\" citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]\u003c/p\u003e \u003cp\u003eIn our case, the extrapulmonary hamartoma was located at pleural surface and the chest ct showed no-calcification. Pathological examination revealed pleural surface nodule exhibiting a high fat content, and a small quantity of cartilage tissue was observed.These pieces of evidence supported for the presence of hamartoma. To date, extrapulmonary hamartomas that fit these several features have not been reported. We treated our patient with surgery and there were no recurrence. Usually, the mediastinal window of chest ct and pathological examination will suggest calcifications of pulmonary hamartoma. Our patient's chest ct did not show calcification, which I suspect is because the hamartoma is composed of a large amount of fat and a small amount of cartilage tissue. In our opinion,this case should be differentiated from lipoma and other hypodense neoplasms.\u003c/p\u003e \u003cp\u003eIn summary, we present a rare extrapulmonary hamartomas that necessitates differentiation from hypodense neoplasms.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003e \u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eWritten informed consent to publish was obtained from the study participants.\u003c/p\u003e\n\u003cp\u003eEthics approval and consent to participate: Ethics approval and consent was obtained.\u003c/p\u003e\n\u003cp\u003eConsent to Publish declaration: Applicable.\u003c/p\u003e\n\u003cp\u003eAvailability of data and materials: (this manuscript does not report data generation or analysis).\u003c/p\u003e\n\u003cp\u003eCompeting interests: The authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003eFunding Declaration: This artical Supported by Zhu Xiu shan Talent Project of Ningbo No.2 Hospital(Grant No.2023HMYQ07).\u003c/p\u003e\n\u003cp\u003eAuthors\u0026rsquo; contributions: Shaoqing Huang wrote the main manuscript text and supported the fund. Jie Li prepared figures. All authors reviewed the manuscript.\u003c/p\u003e\n\u003cp\u003eInformed consent from all subjects for publication of identifying information/images in an online open-access publication under Consent for publication.\u0026nbsp;\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eEndo T, et al. Extrapulmonary hamartoma. Gen Thorac Cardiovasc Surg. 2011;59(3):209\u0026ndash;11.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eFan M, Lin Y, Liu L. Multiple pulmonary chondroid hamartoma. J Thorac Oncol. 2014;9(7):1053\u0026ndash;4.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eTomiyasu M, et al. An intrapulmonary chondromatous hamartoma penetrating the visceral pleura: report of a case. Ann Thorac Cardiovasc Surg. 2002;8(1):42\u0026ndash;4.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKaptanoğlu M, et al. Pulmonary hamartoma, a rare presentation. Eur J Cardiothorac Surg. 2001;20(5):1031.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eTeramoto K, Suzumura Y. Multiple pulmonary hamartomas penetrating the visceral pleura: report of a case. Surg Today. 2007;37(12):1087\u0026ndash;9.\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"journal-of-cardiothoracic-surgery","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"jcts","sideBox":"Learn more about [Journal of Cardiothoracic Surgery](http://cardiothoracicsurgery.biomedcentral.com)","snPcode":"13019","submissionUrl":"https://submission.nature.com/new-submission/13019/3","title":"Journal of Cardiothoracic Surgery","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"hamartoma, Extrapulmonary hamartoma,video-assisted thoracoscopic surgery (VATS)","lastPublishedDoi":"10.21203/rs.3.rs-4843533/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4843533/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Pulmonary hamartomas are common. However，extrapulmonary hamartomas are very rare. We treated a patient with a pulmonary nodule at the left lower lobe by uniportal video-assisted thoracoscopic wedge resection, which showed a yellow nodule located on the visceral pleura. Pathology showed that the nodule contained a small amount of cartilage tissue and was diagnosed as hamartoma. 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