Mitotic activity of smooth muscle cells of the myoma: Does hormonal stimulation have an effect on the number of mitoses?

Tatjana Kastratović, Irena Tanasković, Vesna Lačković, Marija Šorak, Vesna Stanković, Biljana Ljujić, Srdjan Sedlar, Aleksandar Živanović
In: Archives of Biological Sciences · 2010 · vol. 62(1) , pp. 39–45 · doi:10.2298/abs1001039k · W2015353927
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Abstract

Myomas develop as a result of increased mitotic (proliferating) activity of smooth muscle cells. In this study we examined the pathohistological samples of 176 myomas and their endometria that were obtained after hysterectomy from patients in the proliferative (follicular) and secretory (luteal) phase of the menstrual cycle. We examined the mitotic activity of the myoma cells in both phases and established that the average number of mitoses in the proliferative phase was significantly larger compared to the secretory phase, and that in the proliferative phase of the cycle there exists a statistically significant convergent association of the number of mitoses in the endometrium and in myomas. The number of endometrial mitoses is significantly larger than in myomas in both phases of the cycle.
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Archives of Biological Sciences 2010 Volume 62, Issue 1, Pages: 39-45 Mitotic activity of smooth muscle cells of the myoma: Does hormonal stimulation have an effect on the number of mitoses? Kastratović Tatjana (Katedra za ginekologiju i akušerstvo, Medicinski fakultet, Kragujevac) Myomas develop as a result of increased mitotic (proliferating) activity of smooth muscle cells. In this study we examined the pathohistological samples of 176 myomas and their endometria that were obtained after hysterectomy from patients in the proliferative (follicular) and secretory (luteal) phase of the menstrual cycle. We examined the mitotic activity of the myoma cells in both phases and established that the average number of mitoses in the proliferative phase was significantly larger compared to the secretory phase, and that in the proliferative phase of the cycle there exists a statistically significant convergent association of the number of mitoses in the endometrium and in myomas. The number of endometrial mitoses is significantly larger than in myomas in both phases of the cycle. Keywords: Mitotic activity, myoma, menstrual cycle https://doi.org/10.2298/ABS1001039K Full text ( 429 KB) Tanasković Irena (Katedra za histologiju i embriologiju, Medicinski fakultet, Kragujevac) Lačković Vesna (Institut za histologiju i embriologiju, Medicinski fakultet, Beograd) Šorak Marija (Katedra za ginekologiju i akušerstvo, Medicinski fakultet, Kragujevac) Stanković Vesna (Katedra za patologiju, Medicinski fakultet, Kragujevac) Ljujić Biljana (Katedra za genetiku, Medicinski fakultet, Kragujevac) Sedlar S. (Odeljenje za ginekologiju i akušerstvo, Zdravstveni centar, Sremska Mitrovica) Živanović A. (Katedra za ginekologiju i akušerstvo, Medicinski fakultet, Kragujevac)

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