Solving the Mystery of Origin of Life—GADV Hypothesis

The origin of life has been mainly studied based on three ideas, RNA world hypothesis, hydrothermal vent hypothesis and space-origin hypothesis. However, the “mystery” has not been solved still now in spite of strenuous efforts of many researchers for more than 40 years. On the contrary, I proposed one idea, [GADV]-protein world hypothesis (GADV hypothesis), about 20 years ago, which insists that life emerged from [GADV]-protein world formed by pseudo-replication of [GADV]-proteins. [GADV] or GADV means four amino acids, Gly [G], Ala [A], Asp [D] and Val [V]. It was found in subsequent studies that the first gene was formed through processes starting with immature [GADV]-proteins or in a bottom-up manner. Furthermore, it has been confirmed that the first genetic system composed of ds-(GNC)n RNA gene, anticodon stem-loop (AntiC-SL) tRNA (GNC primeval genetic code) and [GADV]-protein was established at the same time when the first gene was formed. It has been also confirmed that the genetic system never be established through a process starting with gene or tRNA. From the results, it has been concluded that life arose as expected by GADV hypothesis and that the “mystery” of the origin of life has been solved.