Outcome of IVF-ET treated with domestic gonadotropin in infertile patients with endometriosis

Objective:To compare the outcome of IVF-ET treated with domestic or imported gonadotropin in infertile patients with endometriosis.Methods:A retrospective analysis was performed in infertile endometriosis patients undergone IVFET in our center from January 2010 to January 2014.The patients fulfilled all the including criteria were divided into group A(domestic drug,201 patients)and group B(imported drug,880 patients).The characteristics of patients,data of controlled ovarian stimulation cycles,and outcomes were compared between the two groups.Results:The patients in group A and B were significantly different in terms of age(32.6±3.3vs.31.7±3.8),duration of infertility[(6.6±3.9)years vs.(6.0±3.6)years]and basal ovarian antral folliclecount(AFC)(8.3±4.1vs.9.1±4.2)(P0.05).There was no significant difference in cycle cancel rate(11.9% vs.12.8%)and cycle cancel reasons(P0.05).The gonadotropin launch doses[(250.5±55.7)U vs.(227.3±52.6)U],total doses[(2 626.4±804.6)U vs.(2 432.2±750.4)U],follicle number(9.3±4.7vs.10.1±5.0),retrieval oocyte number(8.3±5.0vs.9.3±5.1),MⅡ oocyte number(6.9±4.4vs.8.0±4.8),oocyte retrieval rate(88.7% vs.91.9%),retrieval maturate oocyte rate(83.7% vs.85.9%),transferable embryo number(3.1±2.6vs.3.7±2.3),high quality embryo number(1.0±0.8vs.1.3±1.1)were significantly different between the two groups(P0.05).The total cost for gonadotropin in group A were significantly lower than that in group B(5 258.4RMB vs.9 979.0RMB,P0.05).There were 177 embryo transfer cycles in group A and 767 cycles in group B.There was no significant differences in the clinical pregnancy rate(57.1% vs.64.9%),implantation rate(40.3% vs.45.7%),abortion rate(9.9%vs.12.0%),live birth rate(49.2%vs.54.6%)and birth defects rate(3.3%vs.2.5%)between the two groups(P0.05).Conclusions:The clinical pregnancy rate,live birth rate and birth defects rate of IVF-ET conducted with domestic or imported gonadotropin in infertility women with endometriosis were not significantly different.Domestic gonadotropin is safe and cheap,and a good choice for infertile patients with endometriosis.