Expression and clinical significance of PTEN in ovarian endometrioma and endometrioid carcinoma

Objective:To investigate the expression and clinical significance of PTEN in ovarian endometrioma and endometrioid carcinoma.Methods:The expression of PTEN was evaluated by immunohistochemical staining in tumor specimens of normal endometrial tissue(n=20),normal ovarian tissue(n=20),ovarian endometrioma(n=32);ovarian endometrioid carcinoma(n=25).Results:There was no significant difference in the expression of PTEN protein between ovarian endometrioma and normal ovarian tissues and normal endometrial tissue(P0.05).Expression of PTEN was negatively correlated with clinicopathological staging of ovarian endometrioma(P0.05).The expression of PTEN was significantly lower in ovarian endometrioid cancer than the one in ovarian endometrioma(P0.05).Conclusion:PTEN plays a role in the aggravated progression of and may be a potent biodynamic criteria and a novel molecular target for clinical therapy.