Gas chromatography/mass spectrometry characterization of urinary metabolites of danazol after oral administration in human
Non-randomised trial
OA: closed
CC0
⤵ 3 in-corpus citations
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Gas chromatography/mass spectrometry identified four new urinary metabolites of danazol in healthy volunteers, proposing specific biomarkers for detecting the drug's abuse.
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Abstract
Danazol (17alpha-pregna-2,4-dien-20-yno [2,3-d]-isoxazol-17beta-ol), is a synthetic derivative of ethisterone, structurally related to stanozolol. For this reason its use as doping agent has been investigated. Danazol (Runch) (200 mg) were orally administered to two healthy male volunteers. Urine samples were collected up to 1-week post-dose. Four new metabolites have been identified in addition to the five previously reported. We propose the monitorization of 6beta-hydroxy-2-hydroxymethyl-1,2-dehydroethisterone and 6beta,16epsilon-dihydroxy-2epsilon-hydroxymethyl-ethisterone by free fraction analysis. In a same way, we proposed to detect the principal isomer of a mono-hydroxylated metabolite of 6beta-hydroxy-2epsilon-hydroxymethylethisterone in the conjugated fraction. We conclude that new metabolites can be included for the detection of danazol abuse since the main metabolite ethisterone is excreted relatively fast in urine.
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References (11)
- Consensus statement for the management of chronic pelvic pain and endometriosis: proceedings of an expert-panel consensus process via openalex
- Danazol and its principal metabolites interfere with binding of testosterone, cortisol, and thyroxin by plasma proteins via openalex
- Danazol for the treatment of thrombocytopenia in patients with myelodysplastic syndrome via openalex
- Evaluation and management of women with endometriosis via openalex
- GC-MS characterization of urinary metabolites and changes of ethisterone and testosterone profile after oral administration of danazol in equine via openalex
- The detection of danazol and its significance in doping analysis via openalex
- doi:10.1016/0022-4731(90)90126-d via openalex
- doi:10.1016/0960-0760(95)00276-6 via openalex
- W2602272053 via openalex
- doi:10.1093/clinchem/42.7.1001 via openalex
- doi:10.1093/jat/14.2.91 via openalex
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- openalex
- last seen: 2026-05-13T18:28:36.117479+00:00
- pubmed
- last seen: 2026-10-08T21:03:30.943773+00:00
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