Association of WNT-1 Inducible Signaling Pathway Protein-1 (WISP1) Genetic Polymorphisms with the Risk of Gastric Cancer in Guangxi Chinese

Abstract BackgroundTo date, no study has investigated the association of the WNT1 inducible signaling pathway protein-1 (WISP1) polymorphisms with susceptibility to gastric cancer. Therefore, we conducted this study to explore their relation.Methods204 gastric cancer patients and 227 normal controls were enrolled. The WISP1 SNPs rs2929973, rs7843546 and rs10956697 were selected, and their genotypic distributions were determined through PCR-RFLPResultsIn overall, we could not identify a significant association between WISP1 SNP rs2929973, rs7843546 and rs10956697) and gastric cancer risk. However, subgroup analysis demonstrated that the presence of the rs7843546 T allele was associated with a significantly decreased risk of gastric cancer in Han Chinese ethnicity (CT vs. CC: OR= 0.33, 95%CI = 0.14-0.78; TT vs. CC: OR = 0.29, 95%CI = 0.11-0.76; dominant model CT+TT vs. CC: OR = 0.32, 95%CI = 0.14-0.74). In addition, patients with the rs7843546 TT genotype were around one-third as 0.34 likely (OR = 0.34; 95% CI: 0.14-0.84) than those with the CC genotype to develop stage I/II gastric cancer. Furthermore, individuals ≥50 years old who carried the rs10956697 AC genotype represented significantly decreased risk for gastric cancer (AC vs. CC: OR = 0.58, 95%CI = 0.35-0.98). Smokers with the rs10956697 AC and AC+AA genotype were around one-third likely to develop gastric cancer (OR = 0.28, 95% CI= 0.09-0.82 and OR = 0.32, 95% CI = 0.12-0.89, respectively)ConclusionsWISP1 SNPs rs7843546 and rs10956697 polymorphisms were the first time discovered to reduce the susceptibility to gastric cancer in different subgroup in Guangxi Chinese.