The Effect of colchicine on the prevention of contrast induced nephropathy

Aim: The aim of this study is to investigate the effect of colchicine on contrast induced nephropathy(CIN). Methods: 42 female rats were included in the study. Group1 rats were not subjected to any process. Grup2 rats were given contrast alone. Group3 rats were administered 50μg/kg/day oral colchicine 12 hours before contrast administration and simultaneously with contrast. Group4 rats were given 100μg/kg/day oral colchicine 12 hours before contrast administration and simultaneously with contrast. Group5 rats were given 50μg/kg/day oral colchicine simultaneously with contrast. Group6 rats were administered 100μg/kg/day oral colchicine simultaneously with contrast. Blood samples were collected before administration of contrast and post-contrast 48th hour, and blood urea nitrogen and creatinine levels were studied. At the same time, kidney tissue were taken and evaluated histopathologically. Results: It was found that CIN was not developed in Group1 and the groups administered contrast+colchicine. CIN was observed by 28.5% in the group administered contrast alone. Mild tubular degeneration was found in Group2 compared to the other groups(p<0.001). Evaluating for tubular necrosis and congestion, mild damage was seen in all groups, while moderate damage was observed in Group2(p=0.05). Conclusion: CIN was not developed in the groups administered colchicine. Colchicine may be effective in preventing CIN.