Targeting the function of the transentorhinal cortex to identify early cognitive markers of Alzheimer’s disease

Initial neuropathology of early Alzheimer’s disease accumulates in the transentorhinal cortex. We review empirical data suggesting that tasks that assess cognitive functions supported by the transenthorinal cortex are impaired as early as the preclinical stages of Alzheimer’s disease. These tasks span across various domains, including episodic memory, semantic memory, language, and perception. We propose that all tasks sensitive to Alzheimer-related transentorhinal neuropathology commonly rely on representations of entities supporting the processing and discrimination of items having perceptually and conceptually overlapping features. In the future, we suggest that a screening tool that is sensitive and specific to very early Alzheimer’s disease should probe memory and perceptual discrimination of highly similar entities.