Cerebral signature for pain perception and its modulation in patients with endometriosis: a prospective multicenter trial

Endometriosis is a debilitating chronic disease that affects 10% of women of reproductive age. Pain perception in these patients results from complex mechanisms of peripheral and central sensitization. This project explored the modulation of brain areas responsible for pain, with a particular focus on patients with adenomyosis, a condition frequently associated with endometriosis.Patient recruitment was challenging due to the heterogeneity of the population. Therefore, we focused on patients with uterine endometriosis (adenomyosis), minimizing biases and ensuring greater consistency in the results.Project Objectives:1. Evaluate differences in brain activation before and after treatments for endometriosis/adenomyosis (surgery, medical therapy, or follow-up).2. Identify predictive factors for surgical treatment (vs. follow-up/medical therapy).3. Explore longitudinal changes in pain perception at three time points (T1, T2, T3).