Expression of the glycodelin A gene and the detection of its protein in tissues and serum of ovarian carcinoma patients.

Claudia Richter, C. Richter, Richter C, M. Baetje, Baetje M, Bischof A, A Bischof, Anja Bischof, Makovitzky J, Josef Makovitzky, J Makovitzky, D U Richter, Darko Richter, Richter DU, B. Gerber, Gerber B, Briese V, Volker Briese, V Briese
Anticancer research · 2007 · vol. 27(4A) , pp. 2023–5 · PMID:17649816 · W2181544532
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This study evaluated glycodelin A expression in ovarian carcinoma patients versus those with endometriosis and other cancers, concluding that its determination lacks sufficient sensitivity or specificity for use as a tumor marker.

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Abstract

BACKGROUND: Glycodelin A (GdA), also known as placental protein 14 (PP14), has been detected in endometrial, cervical and ovarian carcinoma cells. It is suspected to be a marker of human ovarian cancer tissues. MATERIALS AND METHODS: We investigated serum, tissue and cyst fluid samples of patients with an ovarian carcinoma in contrast to patients with benign and malignant diseases such as uterine myoma, endometriosis, cervical, uterine and breast cancer, and metastases of bladder and colon carcinoma. Used methods were enzyme-immunoassay, immunohistochemistry (IHC) and polymerase chain reaction (PCR). RESULTS: In 81% of the control group the GdA-expression was negative, which was confirmed by IHC and PCR. Of the ovarian carcinoma group only 52% showed correspondence between IHC and PCR. CONCLUSION: These results indicate that determination of GdA is not sensitive or specific enough for use as a tumour marker.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers, Tumor Gene Expression Glycoproteins Ovarian Neoplasms Pregnancy Proteins Biomarkers, Tumor Enzyme-Linked Immunosorbent Assay Female Glycodelin Glycoproteins Glycoproteins Humans Immunohistochemistry Ovarian Neoplasms Ovarian Neoplasms Polymerase Chain Reaction Pregnancy Proteins Pregnancy Proteins RNA, Messenger RNA, Messenger

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