Genomic analyses identify signaling pathways and biological processes in Human papillomavirus (HPV) infected oral cancer patients

Human papillomavirus (HPV) is a critical cause of the head and neck squamous cell carcinoma. However, the molecular mechanism and biological function of HPV in oral cancer remains unknown. In this study, our aim is to identify the significant molecules and pathways by analyzing the RNA-seq data. The GSE184616 was produced by the Illumina NovaSeq 6000 (Homo sapiens). The KEGG and GO analyses showed PI3K−Akt signaling pathway and Extracellular matrix are the main processes during oral cancer with HPV infection. Moreover, we identified the top ten key molecules including FN1, ACTB, COL3A1, COL5A1, COL4A1], COL4A2, COL5A2, MMP9, COL6A2, BGN. Therefore, our study may provide new insights into the treatment of oral cancer.