Relationship between endometriosis and chemokines/chemokine receptors

The study on endometriosis(EMs) has been focused on abdominal environmental changes and features of ectopic endometrium itself.The increased endometrial adhesion and invasion,decreased peritoneal mesothelial defense function and changes in the micro-environment of peritoneal fluid all are contributive to occurrence and development of ectopic lesions;activation of abdominal immune cells is the central link to development of EMs,chemokines and their receptors take part in recruitment of the immune cells in peritoneal fluid, resulting in changes in immune composition in the peritoneal fluid and serum, which reduced surveillance,identification and destruction of pelvic and abdominal micro-environments for ectopic endometria to escape immune attack of the body,and possibly promote proliferation of endometrium.