Clinical analysis of GnRH-a combined with climen in treatment of endometrosis patients after conservative surgery

Objective:To observe the therapeutic effects and safety of endocrine response of gonadotropin hormone releasing hormone-analogue(GnRH-a) combined with Climen in the treatment of advanced endometrosis after conservative laparoscopic operation.Methods:Seventy-five cases of endometriosis patients were randomly divided into two groups: GnRH-a alone group were treated with GnRH-a by hypodermic injection of six doses,each given at twenty-eight days interval;Add back with Climen group were treated with GnRH-a and Climen during six months.To observe the changes between the two groups before and after treatment,E2,FSH,LH,VAS,Modified Kupperman score,Bone mineral density,BGP etc.were applied.Results:After treatment,E2,FSH and LH of the two groups were declined,E2 of the add back group was significantly higher than that of GnRH-a alone group(P0.05),but no difference was found between the two groups in FSH and LH(P0.05).There was no difference in VAS within the two groups(P0.05).Compared with the GnRH-a alone group,the add back group were lower in Modified Kupperman score(P0.05).Bone mineral density of the GnRH-a alone group were declined obviously.BGP of the add back group were lower than of the GnRH-a alone group(P0.05).Conclusion:GnRH-a combined with Climen add-back therapy is effective in the treatmentof advanced endometrosis after conservative laparoscopic operation.It could reduce perimenpausal syndrome caused by GnRH-a and slow down bone conversion to prevent the occurrence of osteoporosis.GnRH-a combined with Climen is the ideal scheme for the treatment of endometriosis.