Sexually Transmitted Infections in the non-European Union and European Economic Area of the World Health Organization European Region 2021-2023

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European Union and European Economic Area (EU/EEA) countries report data annually on the number of cases of syphilis, gonorrhoea, chlamydia, and lymphogranuloma venereum (LGV) to the European Centre for Disease Prevention and Control. No similar system exists for the non-EU/EEA countries in the WHO European Region, and therefore, the sub-regional overview was unclear due to the limited data availability and inconsistency. Methods We conducted a survey among 24 WHO member states in the WHO European Region that did not belong to the EU/EEA as of June 2024. The survey collected data on STI surveillance systems and numbers of reported cases of syphilis, gonorrhoea, chlamydia and LGV from 2021 to 2023. Results Twenty-one completed the survey, of which 19 (79%) agreed to publish their data. All 19 countries reported surveillance activities for syphilis, 18 for gonorrhoea and chlamydia, and 8 for LGV. The comprehensiveness and coverage of surveillance systems varied between countries and infections. Total cases reported increased from 13,553 to 17,113 (notification rate per 100,000 population 5.4 to 6.9) for syphilis and 12,001 to 13,067 (4.2 to 5.0) for gonorrhoea between 2021 and 2023, while chlamydia cases decreased from 32,556 to 27,802 (13.3 to 11.2). Only one to two LGV cases were reported per year. Various challenges were identified in antimicrobial-resistant gonorrhoea surveillance. Conclusions In non-EU/EEA countries, STI cases are likely to be underreported due to incomplete surveillance systems and other factors. Given the increase in the number of reported cases of syphilis and gonorrhoea between 2021 and 2023 and the significant public health consequences of untreated STIs, an accelerated joint effort to strengthen the surveillance systems of the non-EU/EEA countries is warranted to move towards ending epidemics of STIs in the WHO European Region by 2030. Sexually transmitted infection Syphilis Gonorrhoea Chlamydia Lymphogranuloma venereum Europe Central Asia Figures Figure 1 Figure 2 Figure 3 Figure 4 Background Sexually transmitted infections (STIs) continue to be a significant public health challenge and could have a direct impact on sexual and reproductive health. When left untreated, STIs can lead to long-term irreversible and potentially fatal outcomes, including chronic pelvic pain, cancers, ectopic pregnancies, infertility, adverse pregnancy outcomes, neonatal death, and congenital abnormalities[ 1 ]. Some STIs can also increase the risk of human immunodeficiency virus (HIV) acquisition[ 2 ]. Despite its significant consequences, STIs often do not cause symptoms or may have long asymptomatic periods, which can result in unknowing transmission during sexual intercourse or during pregnancy[ 1 ]. In 2020, there were cumulatively 374 million new cases of the four curable STIs: syphilis, gonorrhoea, chlamydia, and trichomoniasis in adults aged 15–49 years[ 3 ]. World Health Organization (WHO) published strategic frameworks to end STIs as public health concerns by 2030 [ 1 ] , [ 4 ]. A 90% reduction in incidence of syphilis and gonorrhoea is required to achieve the 2030 targets[ 1 ] , [ 4 ]. On the other hand, a WHO progress report published in 2024 showed the challenging reality of the control of STIs; the estimated number of new syphilis cases among adults aged 15–49 years increased by over one million in 2022, reaching eight million worldwide, and gonorrhoea case notification rates in selected high-income countries showed an increasing trend[ 5 ]. In the WHO European region, the European Centre for Disease Prevention and Control (ECDC) routinely collects data from 30 member states of the European Union and European Economic Area (EU/EEA) and publishes annual reports for syphilis[ 6 ], gonorrhoea[ 7 ], chlamydia[ 8 ], and lymphogranuloma venereum (LGV)[ 9 ]. Their latest reports, which covered up to 2023, revealed an increasing trend in reported cases of these diseases, which has raised significant concerns[ 10 ]. On the other hand, data from non-EU/EEA countries in the WHO European Region are much more limited, and the latest available data is from a WHO survey of non-EU/ EEA member states covering 2015 to 2019, in which 15 member states responded, and the total number of reported cases syphilis, gonorrhoea and chlamydia fell between 2015 and 2019[ 11 ]. A recent review of STI surveillance records in 53 countries within the WHO European Region in 2023 found limited availability and inconsistency in STI data for non-EU/EEA countries[ 12 ]. At the same time, an increasing trend in drug-resistant gonorrhoea has been reported in the EU/EEA[ 13 ] and worldwide[ 14 ]. However, only six non-EU/EEA countries in the WHO European Region have ever reported to the WHO Gonococcal AMR Surveillance Programme (WHO-GASP) as of 2018[ 14 ]. A previous systematic review by Medland et al. covering 2012 to 2020 identified only a few countries in non-EU/EEA having national surveillance systems for monitoring antimicrobial-resistant gonorrhoea[ 15 ]. To address these gaps, the WHO Regional Office for Europe conducted an STI survey sent to 24 non-EU/EEA member states in 2024. This study aimed to collect data on national surveillance systems for STIs, including surveillance for drug-resistant gonorrhoea, reported cases of STIs in adults, and data on prevalence studies. In addition, the survey collected information on congenital syphilis and programmatic indicators linked to the elimination of mother-to-child transmission, which is discussed in a separate paper. Methods Data collection process The WHO Regional Office for Europe distributed the survey “WHO Annual Reporting Form on Sexually Transmitted Infections for the period January-December 2021–2023” (see Additional File 1) to the 24 non-EU/EEA WHO member states through official correspondence in June 2024. The countries included in the survey were: Albania, Andorra, Armenia, Azerbaijan, Belarus, Bosnia and Herzegovina, Georgia, Israel, Kazakhstan, Kyrgyzstan, Monaco, Montenegro, North Macedonia, Republic of Moldova, Russian Federation, San Marino, Serbia, Switzerland, Tajikistan, Türkiye, Turkmenistan, Ukraine, United Kingdom, and Uzbekistan (in alphabetical order). National focal point persons were selected by country representatives and asked to complete the survey in English or Russian. The survey collected data on surveillance systems and the number of reported cases of syphilis, gonorrhoea, chlamydia, and LGV. For the reported case data, the countries reported based on their own case definitions. Data analysis 1. Surveillance systems We collected data on national surveillance systems: type of data collection system (universal or sentinel), data sources (public sectors only or both public and private sectors). Also, to evaluate the completeness of the surveillance, countries were asked to estimate reporting coverage [(Number of reported cases/Number of actual cases) *100 (%)] of each infection (< 25%, 26–50%, 51–75%, and 76–100%). In addition, countries were asked whether they have national surveillance systems for monitoring antimicrobial-resistant gonorrhoea (Neisseria gonorrhoeae) and also about the challenges to participating in WHO-GASP. 2. Number of reported cases of syphilis, gonorrhoea, chlamydia and LGV Based on the number of reported cases of syphilis, gonorrhoea, chlamydia and LGV, notification rates per 100,000 population in each year from 2021 to 2023 were calculated. Notification rates were calculated by dividing the number of reported cases (numerator) by the population of the respective reporting year (denominator) and multiplying by 100,000. For countries using a sentinel surveillance system, numbers of cases were not included in the calculation of national or overall rates, but they were included in the total number of reported cases. Denominators only included the population of countries which provided data for the respective years. Notification rates by gender were also calculated by dividing the number of reported cases in male or female (numerator) by the male or female population of the respective reporting year (denominator) and multiplying by 100,000. The change in the notification rate of syphilis, gonorrhoea and chlamydia was examined using data from countries that consistently reported the number of cases for three years with available gender disaggregation. Male-to-female ratios were also calculated for syphilis, gonorrhoea, and chlamydia using number of reported cases in 2023. Only the countries which provided gender-disaggregated data were included. The population data was extracted for the years 2021, 2022 and 2023 from the United Nations World Population Prospects[ 16 ]. Ethical statement Ethical approval was unnecessary for this study because data were collected as part of surveillance activities, and no individual-level data were obtained. Results As of January 2025, 21 member states out of 24 completed the survey (response rate 88%), of which 19 (79%) agreed to publish the data. These countries are: Albania, Andorra, Armenia, Azerbaijan, Belarus, Georgia, Israel, Kyrgyzstan, Monaco, Montenegro, North Macedonia, Republic of Moldova, San Marino, Serbia, Switzerland, Tajikistan, Türkiye, Ukraine, and Uzbekistan (in alphabetical order). 1. Surveillance systems The reported details of surveillance systems for each country are shown in Table 1. All 19 countries reported surveillance activities for syphilis, 18 for gonorrhoea and chlamydia, and 8 for LGV. For the type of data collection system, 15 reported universal surveillance for syphilis, 13 for gonorrhoea and 13 for chlamydia. For syphilis, 11 countries (58%) reported having universal surveillance that covered both the public and private sectors, and 13 countries (68%) estimated coverage was between 76-100%. For gonorrhoea and chlamydia, nine countries (50%) reported having universal surveillance that covered both the public and private sectors, and 10 countries for gonorrhoea (56%) and nine (50%) for chlamydia estimated coverage was between 76-100%. Regarding LGV, of the eight countries that reported having an LGV-specific surveillance system, six used universal surveillance system and four collected data from both the public and private sectors. Table 1. Surveillance systems in 19 non-EU/EEA member states in the WHO European Region Syphilis Gonorrhoea Chlamydia LGV Country Universal or Sentinel Data source Coverage Universal or Sentinel Data source Coverage Universal or Sentinel Data source Coverage Universal or Sentinel Data source Coverage Albania U Both 76-100 No surveillance No surveillance No surveillance Andorra U Both 76-100 U Both 76-100 U Both 76-100 U Both 76-100 Armenia U Both 76-100 U Both <25 U Both <25 No surveillance Azerbaijan U Public 76-100 U Public 76-100 U Public 76-100 U Public NDR Belarus U Both 76-100 S Public 76-100 S Public 76-100 U Both NDR Georgia U Both 76-100 U Both 76-100 U Both 76-100 No surveillance Israel U Public NDR U Public NDR U Public NDR No surveillance Kyrgyzstan NDR Both 76-100 NDR Both 76-100 NDR Both NDR No surveillance Monaco S Public <25 S Public <25 S Public <25 S Public <25 Montenegro U Both <25 U Both <25 U Both <25 No surveillance North Macedonia U Both NDR U Both NDR U Both NDR U Both NDR Republic of Moldova U Both 76-100 U Both 76-100 U Both 76-100 No surveillance San Marino U Public 76-100 U Public 76-100 U Public 76-100 U Public NDR Serbia U Both 76-100 U Both 26-50 U Both 26-50 U Both NDR Switzerland U Both 76-100 U Both 76-100 U Both 76-100 Part of chlamydia surveillance Tajikistan NDR NDR NDR NDR NDR NDR NDR NDR NDR NDR NDR NDR Türkiye U Both 76-100 U Both 76-100 U Both 76-100 No surveillance Ukraine U Public NDR U Public NDR U Public NDR No surveillance Uzbekistan S Public 76-100 S Public 76-100 S Public 76-100 S Public 76-100 NDR; no data reported. Table 2. Drug-resistant gonorrhoea surveillance in 19 non-EU/EEA member states in the WHO European Region Country National Surveillance Reporting to WHO-GASP Challenges mentioned to participating in WHO-GASP Albania No No N/A Andorra No No N/A Armenia No No Lack of national AMR surveillance programs, Resource limitations, Technical expertise and capacity gaps, Limited coordination mechanisms Azerbaijan No No N/A Belarus No No a N/A Georgia Yes No N/A Israel Yes No a N/A Kyrgyzstan No No a N/A Monaco No No N/A Montenegro No No No referent laboratory, Low testing rates, Limited number of isolates North Macedonia Yes No No information on how to report to WHO GASP Republic of Moldova No No Lack of infrastructure San Marino No Unknown N/A Serbia No No No national program, No national reference laboratory Switzerland Yes Yes N/A Tajikistan No Unknown N/A Türkiye No Unknown N/A Ukraine No No a Lack of a single electronic data collection system, Insufficient provision of laboratory reagents, Lack of requirements Uzbekistan No Unknown N/A N/A; not available a These countries have reported to WHO GASP at least once by 2020 according to GHO data: https://www.who.int/data/gho/data/themes/topics/indicator-groups/indicator-group-details/GHO/number-of-isolates-tested-(who-gasp-amr) Table 2 summarizes the data on surveillance for antimicrobial-resistant gonorrhoea. Four countries, Georgia, Israel, North Macedonia and Switzerland, reported having national gonococcal AMR monitoring systems. Table 2 also shows the countries that reported to the WHO GASP. Among four countries with a national monitoring system, three did not report to WHO GASP. North Macedonia mentioned a lack of information as a reason for not reporting. In addition, five countries that did not collect data on AMR provided information on the challenges to participating in WHO GASP. These included a lack of laboratory capacity, funding, infrastructure, technical expertise, a coordinating body, and a single electronic data collection system. 2. Number of reported syphilis, gonorrhoea, chlamydia and LGV cases Nineteen countries reported data on syphilis, 18 on gonorrhoea, and 17 on chlamydia for all three years. The number of cases and notification rates per 100,000 population for syphilis, gonorrhoea and chlamydia are shown in Table 3. In 2021, there were 13,553 reported syphilis cases from the 19 non-EU/EEA member states, which is equivalent to a notification rate of 5.4 per 100,000. The number of cases and rate increased to 15,960 (6.4 per 100,000) in 2022 and 17,113 (6.9 per 100,000) in 2023. A similar change was also observed for gonorrhoea; the number of cases increased from 12,001 in 2021 (4.2 per 100,000) to 12,544 in 2022 (4.5 per 100,000) and then to 13,067 (5.0 per 100,000) in 2023. Unlike syphilis and gonorrhoea, reported cases of chlamydia fell between 2021 and 2023; in 2021, there were 32,556 reported cases (13.3 per 100,000), and in 2023, 27,802 (11.2 per 100,000). To assess the change in the longer term, we compared the average number of cases from 2021 to 2023 with the latest available data from our previous STI survey between 2015 and 2019 [11] (see Additional File 2). Syphilis cases increased in eight out of 12 countries with available data. Gonorrhoea and chlamydia decreased in nine out of 11 and nine out of 10 countries, respectively. For LGV, only eight countries in 2023 and seven countries in 2021 and 2022 reported the number of cases, of which two countries have a sentinel surveillance system. The reporting countries were Andorra (starting from 2023), Azerbaijan, Belarus, North Macedonia, Monaco, San Marino, Serbia and Uzbekistan. Among these eight countries, six reported zero cases for all reporting years, and there was one reported case in 2021 and 2023 (both from Monaco), and two cases were reported (Monaco and Uzbekistan) in 2022. Table 3. Total number of reported cases and notification rates of syphilis, gonorrhoea and chlamydia with national data from 19 non-EU/EEA member states, the WHO European Region, 2021-2023 Syphilis Gonorrhoea Chlamydia Country 2021 2022 2023 2021 2022 2023 2021 2022 2023 N Rate N Rate N Rate N Rate N Rate N Rate N Rate N Rate N Rate Albania 47 1.6 18 0.6 111 3.9 NDR NDR NDR NDR NDR NDR Andorra 0 0.0 3 3.8 5 6.2 2 2.6 2 2.5 11 14.1 NDR NDR 4 4.9 Armenia 439 15.3 604 21.0 710 25.5 271 9.4 241 8.4 193 6.7 916 31.9 492 17.1 604 20.5 Azerbaijan 837 8.2 1,127 10.9 1,130 10.9 252 2.5 228 2.2 327 3.2 610 6.0 395 3.8 219 2.1 Belarus 975 10.5 1129 12.3 1,101 11.5 710 NRC 956 NRC 899 NRC 3,081 NRC 2,615 NRC 2,610 NRC Georgia 1,096 28.9 1,189 31.3 1,263 33.8 498 13.1 478 12.6 497 13.1 1,111 29.3 927 24.4 1,039 27.3 Israel 632 7.1 696 7.6 793 8.8 846 9.5 639 7.0 664 7.4 1,501 16.8 907 10.0 906 9.8 Kyrgyzstan 274 4.0 348 5.0 479 7.2 146 2.1 209 3.0 178 2.6 1,243 18.2 1,041 15.0 907 12.8 Monaco 4 NRC 6 NRC 11 NRC 1 NRC 1 NRC 1 NRC 1 NRC 1 NRC 1 NRC Montenegro 5 0.8 4 0.7 6 1.0 0 0.0 0 0.0 7 1.2 15 2.5 10 1.6 1 0.2 North Macedonia 5 0.3 22 1.2 60 2.9 0 0.0 0 0.0 8 0.4 34 1.8 31 1.7 26 1.4 Republic of Moldova 1,269 42.0 1,324 43.6 1,142 34.9 544 18.0 431 14.2 285 9.4 2,066 68.3 1,954 64.3 1,544 50.3 San Marino 18 51.4 11 32.4 16 53.3 1 2.9 5 14.7 1 2.9 4 11.4 4 11.8 6 17.6 Serbia 176 2.6 215 3.2 211 2.9 106 1.6 79 1.2 121 1.8 319 4.7 358 5.3 458 6.8 Switzerland 729 8.4 844 9.6 810 9.3 4,079 46.8 5,122 58.3 6,101 70.1 12335* 141.7 13120* 149.2 12780* 144.1 Tajikistan 266 2.7 333 3.3 324 3.3 136 1.4 106 1.0 69 0.7 124 1.2 161 1.6 136 1.3 Türkiye 2,785 3.2 3,542 4.1 3,646 4.3 57 0.1 136 0.2 84 0.1 62 0.1 31 0.0 32 0.0 Ukraine 1,540 3.5 1,581 3.9 2,053 5.2 1,296 2.9 952 2.3 872 2.0 5,582 12.6 3,522 8.6 3,389 9.0 Uzbekistan 2,456 NRC 2,964 NRC 3,242 NRC 3,056 NRC 2,959 NRC 2,749 NRC 3,552 NRC 3,422 NRC 3,140 NRC Total 13,553 5.4 15,960 6.4 17,113 6.9 12,001 4.2 12,544 4.5 13,067 5.0 32,556 13.3 28,991 11.5 27,802 11.2 NDR; no data reported, NRC; no rate calculated (because the numbers were based on sentinel surveillance) *including LGV Disaggregated data by gender was available consistently for 18 member states for syphilis and 17 for gonorrhoea and chlamydia. Figure 1 shows notification rates per 100,000 population for syphilis, gonorrhoea and chlamydia in total and by gender from 2021 to 2023. For syphilis, the overall notification rate increased in both men and women from 2021 to 2023: 7.9 to 10.0 (+27%) for men and 3.4 to 4.5 (+32%) for women. Similarly, for gonorrhoea, rates increased in the same period by 10% (7.6 to 8.3 per 100,000) in men and by 13% (2.6 to 2.9 per 100,000) in women. The decrease in chlamydia was observed among both genders, but women (notification rate of 16.5 in 2021 to 13.9 in 2023, 16% reduction) contributed more to the decline than men (10.6 in 2021 to 9.6 in 2023, 10% reduction) (Fig. 1). The national and overall male-to-female ratio for syphilis, gonorrhoea and chlamydia are shown in Fig. 2 (a, b, c). For syphilis and gonorrhoea, the male-to-female ratio in all countries was 1.0 or greater. For syphilis, the overall male-to-female ratio was 2.1 in 2023 [range 1.0 in Tajikistan to 14.1 in Serbia]. For gonorrhoea, the overall ratio was 3.1 [range 1.5 (Georgia) – 29.3 (Serbia)]. For chlamydia, the ratio was less than 1.0 in 11 of 15 countries (an overall ratio of 0.7, ranging from 0.2 in Serbia to 3.0 in Andorra). While all reporting countries have sex-disaggregated data for at least one infection as of 2023, only five countries had available modes of transmission data. Regarding age disaggregation, 15 countries provided the number of cases for pre-defined age groups used by ECDC: 14, 15-19, 20-24, 24-34, 35-44, 45 and over, and four were unable to report the numbers based on this age grouping and used different grouping. Discussion To our knowledge, this is the first study which revealed an increase in STIs in non-EU/EEA. Before this study, the sub-regional overview was unclear due to the limited data availability and inconsistency. This study employed a uniform data collection method, achieved a high response rate and revealed an increase in syphilis and gonorrhoea among the non-EU/EEA sub-region. Syphilis showed an increase with a notification rate of 5.4 in 2021 to 6.9 in 2023, which was similar to the reported rates for EU/EEA (6.4 in 2021 and 10.0 in 2023)[17]. While Gonorrhoea cases also increased, larger gaps were observed in notification rate; the rates for non-EU/EEA and EU/EEA were 4.2 and 11.8 in 2021 and 5.0 and 25.0 in 2023, respectively[17]. Chlamydia showed a constant decline, which is not consistent with reports from the EU/EEA, and there were significant gaps in rates between non-EU/EEA and EU/EEA; the rates for non-EU/EEA and EU/EEA were 13.3 and 76.2 in 2021, 11.5 and 89.0 in 2022, and 11.2 and 70.4 in 2023, respectively[17]. There was a correlation between the completeness of surveillance systems in the non-EU/EEA countries and gaps in the notification rate between non-EU/EEA and EU/EEA; the gap is narrower in diseases with more comprehensive surveillance systems, such as syphilis. It is unclear to what extent these gaps between EU/EEA and non-EU/EEA countries reflected a true difference in incidence or resulted from gaps in the completeness of reporting. In a previous narrative review on bacterial STIs in non-EU/EEA, the rates for Syphilis (11.3 per 100,000 population in 2021), Gonorrhoea (6.27 per 100,000) and Chlamydia (23.76 per 1000,000) were higher than our results[12]. This might be because of the difference in data sources; our study used national data collected uniformly in the same timeframe and included data from the countries that the previous study did not include. Comparison with data from our previous survey suggested that an increase in syphilis and a decrease in chlamydia can also be observed in the long term. However, because of the limited availability and inconsistency of the previous data, further analyses were difficult. To assess the long-term trend of STIs in the non-EU/EEA, it is important to continue the coordinated data collection process on a regular basis. There was not adequate data for LGV as most countries do not have national surveillance systems. LGV type of chlamydia has many specific characteristics: epidemiologically concentrated among men who have sex with men, more invasive and systemic infection, and if not treated early, leading to various chronic conditions[18]. Therefore, LGV needs separate surveillance systems from general chlamydia. There is a clear need in non-EU/EEA to develop surveillance systems to monitor LGV cases. Considering that LGV cases are substantially underdiagnosed across Europe[19], in addition to strengthening surveillance, measures such as raising awareness, training for healthcare workers, and improving access to testing should be combined in an integrated approach. At the same time, this study sheds light on the huge challenges of STI surveillance in this sub-region. While most countries had surveillance activities for syphilis, gonorrhoea and chlamydia, comprehensiveness and coverage of the systems were suboptimal. Along with a low number of countries with LGV-specific surveillance, these gaps in the surveillance systems suggest a high probability of underreporting and a strong need for strengthening STI surveillance in the non-EU/EEA countries. The existing gaps in STI surveillance could hinder effective analysis, which can inform the policy. In this study, we could only collect aggregated data as most countries do not have a case-based data collection system, which makes further analyses on reported cases difficult. Due to the different age groups among the reporting countries, we could not analyse the notification rate by age group. For example, in the EU/EEA, a sharp rise in gonorrhoea notification rate in young people, particularly women aged 20–24 years, was observed in 2022-2023[20]. However, we could not examine if there was a similar change in non-EU/EEA due to a lack of age disaggregation. Similarly, due to the significantly limited data availability, it was not possible to analyse the mode of transmission. In the context of the scale-up of pre-exposure prophylaxis (PrEP) for HIV in non-EU/EEA[21], it is particularly important to monitor the incidence of STIs among key populations, such as men who have sex with men, as PrEP does not protect against other STIs than HIV and periodic testing for syphilis, gonorrhoea and chlamydia is strongly recommended by WHO[22]. Age and mode of transmission disaggregation are indispensable in revealing the accurate epidemics of STI transmissions and identifying specific populations who are most at risk for STIs to inform the policy about effective measures. Another issue in surveillance systems was limited monitoring for antimicrobial-resistant gonorrhoea; a dedicated surveillance system has not been established in most countries. One country mentioned the usefulness of established collaboration with regional or international bodies. Considering the public health impact due to the possible spread of antimicrobial-resistant gonorrhoea, including multi-drug resistant gonorrhoea[23], this study showed the vulnerability of non-EU/EEA countries. The challenges countries mentioned mainly resulted from a lack of political commitment and resources. To rapidly detect antimicrobial-resistant gonorrhoea and prevent its further spread, a regional and global collaborative approach to support developing surveillance at the national level should be considered. Taken together, non-EU/EEA countries share many common challenges in STI surveillance, and increased domestic and international support and the establishment of a coordinated international STI data reporting system are urgently needed to monitor and ensure that STI resources are used efficiently to control STIs in non-EU/EEA effectively. The strength of this study is the high number of countries providing data, which enabled us to understand the overall picture of STI epidemics and identify common challenges in STI surveillance systems of this sub-region. At the same time, the data in this study should be interpreted in the light of several limitations. Firstly, a high heterogeneity between reporting countries in not only surveillance systems but also testing policies, access to STI testing, diagnostic techniques and reporting practices should be taken into account. Also, we did not define case definitions for the infections, and the countries used their own definitions. Possible heterogeneity in how the reported cases are defined should be considered. Second, this study is based on the responses from the countries, and no data in the collection form does not necessarily mean that there is no such data. Finally, considering the sub-regional context of high levels of stigma and discrimination[24] , [25] and suboptimal access to and quality of testing[26] along with the above-mentioned suboptimal surveillance systems, it is highly likely that the number of STI cases is underreported, and the real scale of the STI epidemic in non-EU/EEA can be bigger than reported. Conclusions In non-EU/EEA countries in the WHO European Region, the number of reported cases of syphilis and gonorrhoea increased between 2021 and 2023. At the same time, this study sheds light on the enormous challenges of STI surveillance in this subregion. Given the significant public health consequences of untreated STIs, an accelerated joint effort to strengthen the surveillance systems of the non-EU/ EEA countries is warranted to move towards ending epidemics of STIs in the WHO European Region by 2030. Abbreviations ECDC European Centre for Disease Prevention and Control EU/EEA European Union and European Economic Area HIV human immunodeficiency virus LGV lymphogranuloma venereum STIs Sexually transmitted infections WHO World Health Organization WHO-GASP WHO Gonococcal AMR Surveillance Programme Declarations Ethics approval and consent to participate Not applicable Consent for publication Not applicable Availability of data and materials The results of the surveys are available from the corresponding author upon reasonable request. Competing interests All authors declare no conflict of interest. Authors’ contributions MO led the data collection process, wrote the manuscript, and generated tables and figures. J.R., V.G., G.K., and S.B. contributed to the data collection, reviewed the manuscript and agreed on its final version. WHO European Region non-EU/EEA STI Surveillance network members contributed to the acquisition of data by participating in the surveys conducted by the authors. Acknowledgement WHO European Region non-EU/EEA STI Surveillance network members: Albania: Adela Vasili; Andorra: Jennifer Fernández Garcia; Armenia: Hovhannes Hovhannisyan; Azerbaijan: Oleg Salimov; Belarus:Hanna P. Muzychenka; Georgia: Khatuna Zakhashvili and Nino Lomia Israel; Israel: Rivka Rich; Kyrgyzstan: Elvira Torobekova; Monaco: Thomas Althaus; Montenegro: Alma Cicic and Milena Lopicic; North Macedonia: Dragan Kochinski; Republic of Moldova: Aurelia Popov; San Marino: Claudio Muccioli; Serbia: Danijela Simic; Switzerland: Jean-Luc Richard and Thibault Lovey; Tajikistan: Sakina Shoeva; Türkiye: Taliha Karakök and Mehmet Balcı; Ukraine: Liudmila Polanska; Uzbekistan: Dilmurad Zhumanov. The views and opinions expressed in this paper are those of the authors and not necessarily the views, decisions or policies of the World Health Organization (WHO) Funding Not applicable Data sharing statement All available data collected in this study can be shared upon reasonable request after acquiring approval from the respective countries. References World Health Organization (WHO), “Global health sector strategies on, respectively, HIV, viral hepatitis and sexually transmitted infections for the period 2022–2030,” 2022. https://iris.who.int/handle/10665/338901 M. C. Boily et al. , “Heterosexual risk of HIV-1 infection per sexual act: a systematic review and meta-analysis of observational studies,” Lancet. Infect. Dis. , vol. 9, no. 2, p. 118, Feb. 2009, doi: 10.1016/S1473-3099(09)70021-0. World Health Organization (WHO), “Global progress report on HIV, viral hepatitis and sexually transmitted infections, 2021,” 2021. World Health Organization (WHO) Regional Office for Europe, “Regional action plans for ending AIDS and the epidemics of viral hepatitis and sexually transmitted infections 2022–2030,” Copenhagen, 2023. World Health Organization (WHO), “Implementing the global health sector strategies on HIV, viral hepatitis and sexually transmitted infections, 2022–2030: report on progress and gaps 2024,” 2024. European Centre for Disease Prevention and Control, “Syphilis - Annual Epidemiological Report 2023,” 2025. [Online]. Available: https://www.ecdc.europa.eu/en/publications-data/syphilis-annual-epidemiological-report-2023 European Centre for Disease Prevention and Control and WHO Regional Office for Europe, “Gonorrhoea - Annual Epidemiological Report for 2023,” 2025. [Online]. Available: https://www.ecdc.europa.eu/en/publications-data/gonorrhoea-annual-epidemiological-report-2023 European Centre for Disease Prevention and Control, “Chlamydia - Annual Epidemiological Report for 2023,” 2025. [Online]. Available: https://www.ecdc.europa.eu/en/publications-data/chlamydia-annual-epidemiological-report-2023 European Centre for Disease Prevention and Control, “Lymphogranuloma venereum - Annual Epidemiological Report for 2023,” 2025. [Online]. Available: https://www.ecdc.europa.eu/en/publications-data/lymphogranuloma-venereum-annual-epidemiological-report-2023 European Centre for Disease Prevention and Control, “STI cases continue to rise across Europe.” https://www.ecdc.europa.eu/en/news-events/sti-cases-continue-rise-across-europe (accessed Feb. 11, 2025). J. Barbaric et al. , “Surveillance and epidemiology of syphilis, gonorrhoea and chlamydia in the non-European Union countries of the World Health Organization European Region, 2015 to 2020,” Eurosurveillance , vol. 27, no. 8, pp. 1–11, 2022, doi: 10.2807/1560-7917.ES.2022.27.8.2100197. O. Mitjà et al. , “Epidemiology and determinants of reemerging bacterial sexually transmitted infections (STIs) and emerging STIs in Europe,” Lancet Reg. Heal. - Eur. , vol. 34, pp. 1–17, 2023, doi: 10.1016/j.lanepe.2023.100742. European Centre for Disease Prevention and Control, “Gonococcal antimicrobial susceptibility surveillance in the European Union/European Economic Area - Summary of results for 2020,” 2024, [Online]. Available: https://www.ecdc.europa.eu/en/publications-data/gonococcal-antimicrobial-susceptibility-surveillance-2020 World Health Organization (WHO), “Global Health Observatory: Gonococcal antimicrobial susceptibilities: Number of isolates tested (WHO-GASP),” 2024. https://www.who.int/data/gho/data/themes/topics/indicator-groups/indicator-group-details/GHO/number-of-isolates-tested-(who-gasp-amr) (accessed Feb. 10, 2025). N. A. Medland et al. , “Surveillance systems to monitor antimicrobial resistance in Neisseria gonorrhoeae: a global, systematic review, 1 January 2012 to 27 September 2020,” Eurosurveillance , vol. 27, no. 18, 2022, doi: 10.2807/1560-7917.ES.2022.27.18.2100917. United Nations Department of Economic and Social Affairs, “World Population Prospects 2024,” 2024. https://population.un.org/wpp/ (accessed Oct. 01, 2024). European Centre for Disease Prevention and Control, “Surveillance Atlas of Infectious Diseases.” https://atlas.ecdc.europa.eu/public/index.aspx (accessed Jan. 24, 2025). World Health Organization (WHO), “Chlamydia Key facts,” 2024. https://www.who.int/news-room/fact-sheets/detail/chlamydia M. J. Cole et al. , “Substantial underdiagnosis of lymphogranuloma venereum in men who have sex with men in Europe: Preliminary findings from a multicentre surveillance pilot,” Sex. Transm. Infect. , vol. 96, no. 2, pp. 137–142, 2020, doi: 10.1136/sextrans-2019-053972. L. Nerlander et al. , “Sharp increase in gonorrhoea notifications among young people, EU/EEA, July 2022 to June 2023,” Eurosurveillance , vol. 29, no. 10, pp. 1–6, 2024, doi: 10.2807/1560-7917.ES.2024.29.10.2400113. D. Gokengin et al. , “PrEP Scale-Up and PEP in Central and Eastern Europe: Changes in Time and the Challenges We Face with No Expected HIV Vaccine in the near Future †,” Vaccines , vol. 11, no. 1, pp. 3–14, 2023, doi: 10.3390/vaccines11010122. World Health Organization (WHO), “Implementation tool for pre-exposure prophylaxis of HIV infection - Integrating STI services,” 2022. https://www.who.int/publications/i/item/9789240097230 (accessed Nov. 14, 2024). J. S. Jensen and M. Unemo, “Antimicrobial treatment and resistance in sexually transmitted bacterial infections,” Nat. Rev. Microbiol. , vol. 22, no. 7, pp. 435–450, 2024, doi: 10.1038/s41579-024-01023-3. P. J. Garcia, A. E. Miranda, S. Gupta, S. M. Garland, M. E. Escobar, and J. D. Fortenberry, “The role of sexually transmitted infections (STI) prevention and control programs in reducing gender, sexual and STI-related stigma,” EClinicalMedicine , vol. 33, p. 100764, 2021, doi: 10.1016/j.eclinm.2021.100764. A. Uusküla, K. Kangur, and L. A. McNutt, “Barriers to effective STI screening in a post-Soviet society: Results from a qualitative study,” Sex. Transm. Infect. , vol. 82, no. 4, pp. 323–326, 2006, doi: 10.1136/sti.2005.019000. I. Boiko, I. Krynytska, I. Kohut, H. Bezkorovaina, and V. Stepanenko, “Diagnostics of Gonococcal Infection in Ukraine: Current Challenges in Resource-Constrained Settings,” Eurasian J. Med. , vol. 53, no. 3, p. 180, Oct. 2021, doi: 10.5152/EURASIANJMED.2021.20043. Additional Declarations No competing interests reported. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6093564","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":421707021,"identity":"40eabbce-8156-40af-a95e-c82e0d425b4e","order_by":0,"name":"Machiko Otani","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAApUlEQVRIiWNgGAWjYLCCBAYbBgMgfYA45WxgLWlQLQnEamFgOAzWwkCUFn755mcPHuacT9zO3sB4uPAHEVok29jMDRK33U7c2XOA4fAMYmwxOMZgJgHUkrvhRgLDYR7itLB/A2o5R5IWHpAtB0jQItmWUwbUkly/4czBhsM8aURo4Wc+vk3y5zY7Y4PjzYc/89gQoQUJMDaQpn4UjIJRMApGAW4AAKnWOJ43eZZ2AAAAAElFTkSuQmCC","orcid":"","institution":"World Health Organization - Denmark","correspondingAuthor":true,"prefix":"","firstName":"Machiko","middleName":"","lastName":"Otani","suffix":""},{"id":421707022,"identity":"a3b549dd-eec9-45f7-b05f-93552aec0e08","order_by":1,"name":"Jane Rowley","email":"","orcid":"","institution":"World Health Organization","correspondingAuthor":false,"prefix":"","firstName":"Jane","middleName":"","lastName":"Rowley","suffix":""},{"id":421707023,"identity":"15494d5d-b8c4-4963-a760-eb1f4c5c33ef","order_by":2,"name":"Viatcheslav Grankov","email":"","orcid":"","institution":"World Health Organization - Denmark","correspondingAuthor":false,"prefix":"","firstName":"Viatcheslav","middleName":"","lastName":"Grankov","suffix":""},{"id":421707024,"identity":"64989215-523c-4652-9bec-34c3c2a98374","order_by":3,"name":"Giorgi Kuchukhidze","email":"","orcid":"","institution":"World Health Organization - Denmark","correspondingAuthor":false,"prefix":"","firstName":"Giorgi","middleName":"","lastName":"Kuchukhidze","suffix":""},{"id":421707025,"identity":"baaaf579-ae62-4950-9327-695d069eba00","order_by":4,"name":"Stela Bivol","email":"","orcid":"","institution":"World Health Organization - Denmark","correspondingAuthor":false,"prefix":"","firstName":"Stela","middleName":"","lastName":"Bivol","suffix":""},{"id":421707026,"identity":"b616e462-47ce-4891-8f05-f9e9b16df8bd","order_by":5,"name":"WHO European Region non-EU/EEA STI Surveillance network","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"WHO","middleName":"European Region non-EU/EEA STI Surveillance","lastName":"network","suffix":""}],"badges":[],"createdAt":"2025-02-24 05:53:26","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6093564/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6093564/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12889-025-22630-6","type":"published","date":"2025-04-25T15:57:53+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":78699931,"identity":"4d1d6875-f013-4ff3-92a3-e176800c538b","added_by":"auto","created_at":"2025-03-17 18:42:05","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":65581,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eNotification rates per 100,000 population for Syphilis, Gonorrhoea and Chlamydia, 2021-2023\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNotification rates per 100,000 population for syphilis, gonorrhoea and chlamydia in total and by gender from 2021 to 2023. Andorra was not included in the calculation of notification rates by gender as gender disaggregation was not available consistently.\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-6093564/v1/5275b19292522411a8f1f331.png"},{"id":78700069,"identity":"95e5f373-078f-44c8-a48e-fd9ef2704fec","added_by":"auto","created_at":"2025-03-17 18:50:05","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":36469,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eFigure 2a. Male-to-female ratio of syphilis cases by country, 2023.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNational and all non-EU/EEA male-to-female ratios for reported syphilis cases in 2023. Ratios for Andorra, Montenegro and North Macedonia are not available as these countries reported zero female cases.\u003c/p\u003e","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-6093564/v1/1f3b0614d423be126317ee3b.png"},{"id":78699932,"identity":"a8fb6733-6294-4cd6-9f39-c479fe726574","added_by":"auto","created_at":"2025-03-17 18:42:05","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":38039,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eFigure 2b. Male-to-female ratio of gonorrhoea cases by country, 2023.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNational and all non-EU/EEA male-to-female ratios for reported gonorrhoea cases in 2023. Ratios are not available for Andorra, Monaco and Montenegro (zero female cases) and San Marino (zero male cases). Gender-disaggregated data was not available for Albania.\u003c/p\u003e","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/rs-6093564/v1/5d6914c61c0e83c6906563be.png"},{"id":78700070,"identity":"02b85810-afb6-437f-80e4-b6e0a6121058","added_by":"auto","created_at":"2025-03-17 18:50:05","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":36266,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eFigure 2c. Male-to-female ratio of chlamydia cases by country, 2023.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNational and all non-EU/EEA male-to-female ratios for reported chlamydia cases in 2023. Ratios are not available for Monaco (0 female cases) and Montenegro and San Marino (0 male cases). Gender-disaggregated data was not available for Albania.\u003c/p\u003e","description":"","filename":"4.png","url":"https://assets-eu.researchsquare.com/files/rs-6093564/v1/d249cf4841865271a3cebf6c.png"},{"id":81569869,"identity":"2374e6fe-0d36-47f1-b158-356b7891a1f7","added_by":"auto","created_at":"2025-04-28 16:12:11","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1728322,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6093564/v1/07f7f87f-927e-4f7b-b3b1-08220ab1600c.pdf"},{"id":78700068,"identity":"b63e081f-642a-4899-9ced-659e180039f3","added_by":"auto","created_at":"2025-03-17 18:50:05","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":28085,"visible":true,"origin":"","legend":"","description":"","filename":"AdditionalFiles.docx","url":"https://assets-eu.researchsquare.com/files/rs-6093564/v1/fe892754fd192f18c083de0e.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"Sexually Transmitted Infections in the non-European Union and European Economic Area of the World Health Organization European Region 2021-2023","fulltext":[{"header":"Background","content":"\u003cp\u003eSexually transmitted infections (STIs) continue to be a significant public health challenge and could have a direct impact on sexual and reproductive health. When left untreated, STIs can lead to long-term irreversible and potentially fatal outcomes, including chronic pelvic pain, cancers, ectopic pregnancies, infertility, adverse pregnancy outcomes, neonatal death, and congenital abnormalities[\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]. Some STIs can also increase the risk of human immunodeficiency virus (HIV) acquisition[\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. Despite its significant consequences, STIs often do not cause symptoms or may have long asymptomatic periods, which can result in unknowing transmission during sexual intercourse or during pregnancy[\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eIn 2020, there were cumulatively 374\u0026nbsp;million new cases of the four curable STIs: syphilis, gonorrhoea, chlamydia, and trichomoniasis in adults aged 15\u0026ndash;49 years[\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]. World Health Organization (WHO) published strategic frameworks to end STIs as public health concerns by 2030 [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]\u003csup\u003e,\u003c/sup\u003e[\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. A 90% reduction in incidence of syphilis and gonorrhoea is required to achieve the 2030 targets[\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]\u003csup\u003e,\u003c/sup\u003e[\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. On the other hand, a WHO progress report published in 2024 showed the challenging reality of the control of STIs; the estimated number of new syphilis cases among adults aged 15\u0026ndash;49 years increased by over one million in 2022, reaching eight million worldwide, and gonorrhoea case notification rates in selected high-income countries showed an increasing trend[\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eIn the WHO European region, the European Centre for Disease Prevention and Control (ECDC) routinely collects data from 30 member states of the European Union and European Economic Area (EU/EEA) and publishes annual reports for syphilis[\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e], gonorrhoea[\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e], chlamydia[\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e], and lymphogranuloma venereum (LGV)[\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e]. Their latest reports, which covered up to 2023, revealed an increasing trend in reported cases of these diseases, which has raised significant concerns[\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e]. On the other hand, data from non-EU/EEA countries in the WHO European Region are much more limited, and the latest available data is from a WHO survey of non-EU/ EEA member states covering 2015 to 2019, in which 15 member states responded, and the total number of reported cases syphilis, gonorrhoea and chlamydia fell between 2015 and 2019[\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. A recent review of STI surveillance records in 53 countries within the WHO European Region in 2023 found limited availability and inconsistency in STI data for non-EU/EEA countries[\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eAt the same time, an increasing trend in drug-resistant gonorrhoea has been reported in the EU/EEA[\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e] and worldwide[\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e]. However, only six non-EU/EEA countries in the WHO European Region have ever reported to the WHO Gonococcal AMR Surveillance Programme (WHO-GASP) as of 2018[\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e]. A previous systematic review by Medland et al. covering 2012 to 2020 identified only a few countries in non-EU/EEA having national surveillance systems for monitoring antimicrobial-resistant gonorrhoea[\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eTo address these gaps, the WHO Regional Office for Europe conducted an STI survey sent to 24 non-EU/EEA member states in 2024. This study aimed to collect data on national surveillance systems for STIs, including surveillance for drug-resistant gonorrhoea, reported cases of STIs in adults, and data on prevalence studies. In addition, the survey collected information on congenital syphilis and programmatic indicators linked to the elimination of mother-to-child transmission, which is discussed in a separate paper.\u003c/p\u003e"},{"header":"Methods","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003eData collection process\u003c/h2\u003e \u003cp\u003eThe WHO Regional Office for Europe distributed the survey \u0026ldquo;WHO Annual Reporting Form on Sexually Transmitted Infections for the period January-December 2021\u0026ndash;2023\u0026rdquo; (see Additional File 1) to the 24 non-EU/EEA WHO member states through official correspondence in June 2024. The countries included in the survey were: Albania, Andorra, Armenia, Azerbaijan, Belarus, Bosnia and Herzegovina, Georgia, Israel, Kazakhstan, Kyrgyzstan, Monaco, Montenegro, North Macedonia, Republic of Moldova, Russian Federation, San Marino, Serbia, Switzerland, Tajikistan, T\u0026uuml;rkiye, Turkmenistan, Ukraine, United Kingdom, and Uzbekistan (in alphabetical order). National focal point persons were selected by country representatives and asked to complete the survey in English or Russian. The survey collected data on surveillance systems and the number of reported cases of syphilis, gonorrhoea, chlamydia, and LGV. For the reported case data, the countries reported based on their own case definitions.\u003c/p\u003e \u003cp\u003e \u003cb\u003eData analysis\u003c/b\u003e \u003c/p\u003e \u003cp\u003e1. Surveillance systems\u003c/p\u003e \u003cp\u003eWe collected data on national surveillance systems: type of data collection system (universal or sentinel), data sources (public sectors only or both public and private sectors). Also, to evaluate the completeness of the surveillance, countries were asked to estimate reporting coverage [(Number of reported cases/Number of actual cases) *100 (%)] of each infection (\u0026lt;\u0026thinsp;25%, 26\u0026ndash;50%, 51\u0026ndash;75%, and 76\u0026ndash;100%). In addition, countries were asked whether they have national surveillance systems for monitoring antimicrobial-resistant gonorrhoea (Neisseria gonorrhoeae) and also about the challenges to participating in WHO-GASP.\u003c/p\u003e \u003cp\u003e2. Number of reported cases of syphilis, gonorrhoea, chlamydia and LGV\u003c/p\u003e \u003cp\u003eBased on the number of reported cases of syphilis, gonorrhoea, chlamydia and LGV, notification rates per 100,000 population in each year from 2021 to 2023 were calculated. Notification rates were calculated by dividing the number of reported cases (numerator) by the population of the respective reporting year (denominator) and multiplying by 100,000. For countries using a sentinel surveillance system, numbers of cases were not included in the calculation of national or overall rates, but they were included in the total number of reported cases. Denominators only included the population of countries which provided data for the respective years. Notification rates by gender were also calculated by dividing the number of reported cases in male or female (numerator) by the male or female population of the respective reporting year (denominator) and multiplying by 100,000.\u003c/p\u003e \u003cp\u003eThe change in the notification rate of syphilis, gonorrhoea and chlamydia was examined using data from countries that consistently reported the number of cases for three years with available gender disaggregation. Male-to-female ratios were also calculated for syphilis, gonorrhoea, and chlamydia using number of reported cases in 2023. Only the countries which provided gender-disaggregated data were included. The population data was extracted for the years 2021, 2022 and 2023 from the United Nations World Population Prospects[\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e].\u003c/p\u003e \u003c/div\u003e\u003cp\u003eEthical statement\u003c/p\u003e\n\u003cp\u003eEthical approval was unnecessary for this study because data were collected as part of surveillance activities, and no individual-level data were obtained.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eAs of January 2025, 21 member states out of 24 completed the survey (response rate 88%), of which 19 (79%) agreed to publish the data. These countries are: Albania, Andorra, Armenia, Azerbaijan, Belarus, Georgia, Israel, Kyrgyzstan, Monaco, Montenegro, North Macedonia, Republic of Moldova, San Marino, Serbia, Switzerland, Tajikistan, T\u0026uuml;rkiye, Ukraine, and Uzbekistan (in alphabetical order). \u0026nbsp;\u003c/p\u003e\n\u003ch2\u003e1. Surveillance systems\u003c/h2\u003e\n\u003cp\u003eThe reported details of surveillance systems for each country are shown in Table 1. All 19 countries reported surveillance activities for syphilis, 18 for gonorrhoea and chlamydia, and 8 for LGV. For the type of data collection system, 15 reported universal surveillance for syphilis, 13 for gonorrhoea and 13 for chlamydia. For syphilis, 11 countries (58%) reported having universal surveillance that covered both the public and private sectors, and 13 countries (68%) estimated coverage was between 76-100%. For gonorrhoea and chlamydia, nine countries (50%) reported having universal surveillance that covered both the public and private sectors, and 10 countries for gonorrhoea (56%) and nine (50%) for chlamydia estimated coverage was between 76-100%. Regarding LGV, of the eight countries that reported having an LGV-specific surveillance system, six used universal surveillance system and four collected data from both the public and private sectors.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 1. Surveillance systems in 19 non-EU/EEA member states in the WHO European Region\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"906\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 191px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eSyphilis\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 191px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eGonorrhoea\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 191px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eChlamydia\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 191px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eLGV\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eCountry\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eUniversal or Sentinel\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 53px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eData source\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eCoverage\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eUniversal or Sentinel\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 53px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eData source\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eCoverage\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eUniversal or Sentinel\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 53px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eData source\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eCoverage\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eUniversal or Sentinel\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 53px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eData source\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eCoverage\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eAlbania\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" valign=\"bottom\" style=\"width: 191px;\"\u003e\n \u003cp\u003eNo surveillance\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" valign=\"bottom\" style=\"width: 191px;\"\u003e\n \u003cp\u003eNo surveillance\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" valign=\"bottom\" style=\"width: 191px;\"\u003e\n \u003cp\u003eNo surveillance\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eAndorra\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 78px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 44px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eArmenia\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e\u0026lt;25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e\u0026lt;25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" valign=\"bottom\" style=\"width: 191px;\"\u003e\n \u003cp\u003eNo surveillance\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eAzerbaijan\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eBelarus\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eGeorgia\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" valign=\"bottom\" style=\"width: 191px;\"\u003e\n \u003cp\u003eNo surveillance\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eIsrael\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" valign=\"bottom\" style=\"width: 191px;\"\u003e\n \u003cp\u003eNo surveillance\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eKyrgyzstan\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" valign=\"bottom\" style=\"width: 191px;\"\u003e\n \u003cp\u003eNo surveillance\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eMonaco\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e\u0026lt;25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e\u0026lt;25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e\u0026lt;25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e\u0026lt;25\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eMontenegro\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e\u0026lt;25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e\u0026lt;25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e\u0026lt;25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" valign=\"bottom\" style=\"width: 191px;\"\u003e\n \u003cp\u003eNo surveillance\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eNorth Macedonia\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eRepublic of Moldova\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" valign=\"bottom\" style=\"width: 191px;\"\u003e\n \u003cp\u003eNo surveillance\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eSan Marino\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eSerbia\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e26-50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e26-50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eSwitzerland\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" valign=\"bottom\" style=\"width: 191px;\"\u003e\n \u003cp\u003ePart of chlamydia surveillance\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eTajikistan\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eT\u0026uuml;rkiye\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" valign=\"bottom\" style=\"width: 191px;\"\u003e\n \u003cp\u003eNo surveillance\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eUkraine\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eU\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" valign=\"bottom\" style=\"width: 191px;\"\u003e\n \u003cp\u003eNo surveillance\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 144px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eUzbekistan\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003eS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 53px;\"\u003e\n \u003cp\u003ePublic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 69px;\"\u003e\n \u003cp\u003e76-100\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eNDR; no data reported.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 2. Drug-resistant gonorrhoea surveillance in 19 non-EU/EEA member states in the WHO European Region\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"875\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eCountry\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eNational Surveillance\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eReporting to\u0026nbsp;\u003cbr\u003e\u0026nbsp;WHO-GASP\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eChallenges mentioned to participating in WHO-GASP\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eAlbania\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eAndorra\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eArmenia\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eLack of national AMR surveillance programs, Resource limitations, Technical expertise and capacity gaps, Limited coordination mechanisms\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eAzerbaijan\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eBelarus\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eNo\u003csup\u003ea\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eGeorgia\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eIsrael\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eNo\u003csup\u003ea\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eKyrgyzstan\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eNo\u003csup\u003ea\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eMonaco\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eMontenegro\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eNo referent laboratory, Low testing rates, Limited number of isolates\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eNorth Macedonia\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eNo information on how to report to WHO GASP\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eRepublic of Moldova\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eLack of infrastructure\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eSan Marino\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eUnknown\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eSerbia\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eNo national program, No national reference laboratory\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eSwitzerland\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eTajikistan\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eUnknown\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eT\u0026uuml;rkiye\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eUnknown\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eUkraine\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eNo\u003csup\u003ea\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eLack of a single electronic data collection system, Insufficient provision of laboratory reagents, Lack of requirements\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 168px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eUzbekistan\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 102px;\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 108px;\"\u003e\n \u003cp\u003eUnknown\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 497px;\"\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eN/A; not available\u003c/p\u003e\n\u003cp\u003ea These countries have reported to WHO GASP at least once by 2020 according to GHO data: https://www.who.int/data/gho/data/themes/topics/indicator-groups/indicator-group-details/GHO/number-of-isolates-tested-(who-gasp-amr)\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTable 2 summarizes the data on surveillance for antimicrobial-resistant gonorrhoea. Four countries, Georgia, Israel, North Macedonia and Switzerland, reported having national gonococcal AMR monitoring systems. Table 2 also shows the countries that reported to the WHO GASP. Among four countries with a national monitoring system, three did not report to WHO GASP. North Macedonia mentioned a lack of information as a reason for not reporting. In addition, five countries that did not collect data on AMR provided information on the challenges to participating in WHO GASP. These included a lack of laboratory capacity, funding, infrastructure, technical expertise, a coordinating body, and a single electronic data collection system.\u003c/p\u003e\n\u003ch2\u003e2. Number of reported syphilis, gonorrhoea, chlamydia and LGV cases\u003c/h2\u003e\n\u003cp\u003eNineteen countries reported data on syphilis, 18 on gonorrhoea, and 17 on chlamydia for all three years. The number of cases and notification rates per 100,000 population for syphilis, gonorrhoea and chlamydia are shown in Table 3. In 2021, there were 13,553 reported syphilis cases from the 19 non-EU/EEA member states, which is equivalent to a notification rate of 5.4 per 100,000. The number of cases and rate increased to 15,960 (6.4 per 100,000) in 2022 and 17,113 (6.9 per 100,000) in 2023. A similar change was also observed for gonorrhoea; the number of cases increased from 12,001 in 2021 (4.2 per 100,000) to 12,544 in 2022 (4.5 per 100,000) and then to 13,067 (5.0 per 100,000) in 2023. Unlike syphilis and gonorrhoea, reported cases of chlamydia fell between 2021 and 2023; in 2021, there were 32,556 reported cases (13.3 per 100,000), and in 2023, 27,802 (11.2 per 100,000). To assess the change in the longer term, we compared the average number of cases from 2021 to 2023 with the latest available data from our previous STI survey between 2015 and 2019 [11] (see Additional File 2). Syphilis cases increased in eight out of 12 countries with available data. Gonorrhoea and chlamydia decreased in nine out of 11 and nine out of 10 countries, respectively. For LGV, only eight countries in 2023 and seven countries in 2021 and 2022 reported the number of cases, of which two countries have a sentinel surveillance system. The reporting countries were Andorra (starting from 2023), Azerbaijan, Belarus, North Macedonia, Monaco, San Marino, Serbia and Uzbekistan. Among these eight countries, six reported zero cases for all reporting years, and there was one reported case in 2021 and 2023 (both from Monaco), and two cases were reported (Monaco and Uzbekistan) in 2022.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 3. Total number of reported cases and notification rates of syphilis, gonorrhoea and chlamydia with national data from 19 non-EU/EEA member states, the WHO European Region, 2021-2023\u003c/strong\u003e\u003csup\u003e\u0026nbsp;\u003c/sup\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"915\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width: 264px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eSyphilis\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width: 264px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eGonorrhoea\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width: 264px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eChlamydia\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eCountry\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 88px;\"\u003e\n \u003cp\u003e\u003cstrong\u003e2021\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 88px;\"\u003e\n \u003cp\u003e\u003cstrong\u003e2022\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 88px;\"\u003e\n \u003cp\u003e\u003cstrong\u003e2023\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 88px;\"\u003e\n \u003cp\u003e\u003cstrong\u003e2021\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 88px;\"\u003e\n \u003cp\u003e\u003cstrong\u003e2022\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 88px;\"\u003e\n \u003cp\u003e\u003cstrong\u003e2023\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 88px;\"\u003e\n \u003cp\u003e\u003cstrong\u003e2021\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 88px;\"\u003e\n \u003cp\u003e\u003cstrong\u003e2022\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 88px;\"\u003e\n \u003cp\u003e\u003cstrong\u003e2023\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eN\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eRate\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eN\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eRate\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eN\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eRate\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eN\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eRate\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eN\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eRate\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eN\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eRate\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eN\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eRate\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eN\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eRate\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eN\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eRate\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eAlbania\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e1.6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e0.6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e111\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e3.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eAndorra\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e0.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e3.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e6.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e2.6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e2.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e14.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003eNDR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e4.9\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eArmenia\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e439\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e15.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e604\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e21.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e710\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e25.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e271\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e9.4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e241\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e8.4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e193\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e6.7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e916\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e31.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e492\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e17.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e604\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e20.5\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eAzerbaijan\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e837\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e8.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1,127\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e10.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1,130\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e10.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e252\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e2.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e228\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e2.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e327\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e3.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e610\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e6.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e395\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e3.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e219\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e2.1\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eBelarus\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e975\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e10.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1129\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e12.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1,101\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e11.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e710\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e956\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e899\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e3,081\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e2,615\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e2,610\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n 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\u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1,501\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e16.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e907\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e10.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e906\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e9.8\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eKyrgyzstan\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e274\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e4.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e348\u003c/p\u003e\n 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\u003cp\u003e18.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1,041\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e15.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e907\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e12.8\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eMonaco\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n 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\u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e0.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e0.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e1.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e2.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e1.6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n 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style=\"width: 50px;\"\u003e\n \u003cp\u003e285\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e9.4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e2,066\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e68.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1,954\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e64.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1,544\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e50.3\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eSan Marino\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e51.4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e32.4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e53.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e2.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e14.7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e2.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e11.4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e11.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e17.6\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eSerbia\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e176\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e2.6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e215\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 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38px;\"\u003e\n \u003cp\u003e9.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e4,079\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e46.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e5,122\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e58.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e6,101\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e70.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e12335*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e141.7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e13120*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e149.2\u003c/p\u003e\n \u003c/td\u003e\n 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\u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1,540\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e3.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1,581\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e3.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e2,053\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e5.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e1,296\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e2.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e952\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e2.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e872\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e2.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e5,582\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e12.6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e3,522\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e8.6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e3,389\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e9.0\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eUzbekistan\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e2,456\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e2,964\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e3,242\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e3,056\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e2,959\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e2,749\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e3,552\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e3,422\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e3,140\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003eNRC\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 123px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eTotal\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e13,553\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e5.4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e15,960\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e6.4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e17,113\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e6.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e12,001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e4.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e12,544\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e4.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e13,067\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e5.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e32,556\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e13.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e28,991\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e11.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50px;\"\u003e\n \u003cp\u003e27,802\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 38px;\"\u003e\n \u003cp\u003e11.2\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eNDR; no data reported, NRC; no rate calculated (because the numbers were based on sentinel surveillance)\u003c/p\u003e\n\u003cp\u003e*including LGV\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eDisaggregated data by gender was available consistently for 18 member states for syphilis and 17 for gonorrhoea and chlamydia.\u003c/p\u003e\n\u003cp\u003eFigure 1 shows notification rates per 100,000 population for syphilis, gonorrhoea and chlamydia in total and by gender from 2021 to 2023. For syphilis, the overall notification rate increased in both men and women from 2021 to 2023: 7.9 to 10.0 (+27%) for men and 3.4 to 4.5 (+32%) for women. Similarly, for gonorrhoea, rates increased in the same period by 10% (7.6 to 8.3 per 100,000) in men and by 13% (2.6 to 2.9 per 100,000) in women. The decrease in chlamydia was observed among both genders, but women (notification rate of 16.5 in 2021 to 13.9 in 2023, 16% reduction) contributed more to the decline than men (10.6 in 2021 to 9.6 in 2023, 10% reduction) (Fig. 1).\u003c/p\u003e\n\u003cp\u003eThe national and overall male-to-female ratio for syphilis, gonorrhoea and chlamydia are shown in Fig. 2 (a, b, c). For syphilis and gonorrhoea, the male-to-female ratio in all countries was 1.0 or greater. For syphilis, the overall male-to-female ratio was 2.1 in 2023 [range 1.0 in Tajikistan to 14.1 in Serbia]. For gonorrhoea, the overall ratio was 3.1 [range 1.5 (Georgia) \u0026ndash; 29.3 (Serbia)]. For chlamydia, the ratio was less than 1.0 in 11 of 15 countries (an overall ratio of 0.7, ranging from 0.2 in Serbia to 3.0 in Andorra).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eWhile all reporting countries have sex-disaggregated data for at least one infection as of 2023, only five countries had available modes of transmission data. Regarding age disaggregation, 15 countries provided the number of cases for pre-defined age groups used by ECDC: 14, 15-19, 20-24, 24-34, 35-44, 45 and over, and four were unable to report the numbers based on this age grouping and used different grouping.\u0026nbsp;\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eTo our knowledge, this is the first study which revealed an increase in STIs in non-EU/EEA. Before this study, the sub-regional overview was unclear due to the limited data availability and inconsistency. This study employed a uniform data collection method, achieved a high response rate and revealed an increase in syphilis and gonorrhoea among the non-EU/EEA sub-region.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp; Syphilis showed an increase with a notification rate of 5.4 in 2021 to 6.9 in 2023, which was similar to the reported rates for EU/EEA (6.4 in 2021 and 10.0 in 2023)[17]. While Gonorrhoea cases also increased, larger gaps were observed in notification rate; the rates for non-EU/EEA and EU/EEA were 4.2 and 11.8 in 2021 and 5.0\u0026nbsp;and 25.0 in 2023, respectively[17]. Chlamydia showed a constant decline, which is not consistent with reports from the EU/EEA, and there were significant gaps in rates between non-EU/EEA and EU/EEA; the rates for non-EU/EEA and EU/EEA were 13.3 and 76.2\u0026nbsp;in 2021, 11.5 and 89.0 in 2022, and 11.2 and 70.4 in 2023, respectively[17]. There was a\u0026nbsp;correlation between the\u0026nbsp;completeness of surveillance systems in the non-EU/EEA countries and\u0026nbsp;gaps in the notification rate between non-EU/EEA and EU/EEA; the gap is narrower in diseases with more comprehensive surveillance systems, such as syphilis. It is unclear to what extent these gaps between EU/EEA and non-EU/EEA countries reflected a true difference in incidence or resulted from gaps in the completeness of reporting. In a previous narrative review on bacterial STIs in non-EU/EEA, the rates for Syphilis (11.3 per 100,000 population in 2021), Gonorrhoea (6.27 per 100,000) and Chlamydia (23.76 per 1000,000) were higher than our results[12]. This might be because of the difference in data sources; our study used national data collected uniformly in the same timeframe and included data from the countries that the previous study did not include. Comparison with data from our previous survey suggested that an increase in syphilis and a decrease in chlamydia can also be observed in the long term. However, because of the limited availability and inconsistency of the previous data, further analyses were difficult. To assess the long-term trend of STIs in the non-EU/EEA, it is important to continue the coordinated data collection process on a regular basis.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp; There was not adequate data for LGV as most countries do not have national surveillance systems. LGV type of chlamydia has many specific characteristics: epidemiologically concentrated among men who have sex with men, more invasive and systemic infection, and if not treated early, leading to various chronic conditions[18].\u0026nbsp;Therefore, LGV needs separate surveillance systems from general chlamydia. There is a clear need in non-EU/EEA to develop surveillance systems to monitor LGV cases. Considering that LGV cases are substantially underdiagnosed across Europe[19], in addition to strengthening surveillance, measures such as raising awareness, training for healthcare workers, and improving access to testing should be combined in an integrated approach.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp; At the same time, this study sheds light on the huge challenges of STI surveillance in this sub-region. While most countries had surveillance activities for syphilis, gonorrhoea and chlamydia, comprehensiveness and coverage of the systems were suboptimal. Along with a low number of countries with LGV-specific surveillance, these gaps in the surveillance systems suggest a high probability of underreporting and a strong need for strengthening STI surveillance in the non-EU/EEA countries. The existing gaps in STI surveillance could hinder effective analysis, which can inform the policy. In this study, we could only collect aggregated data as most countries do not have a case-based data collection system, which makes further analyses on reported cases difficult. Due to the different age groups among the reporting countries, we could not analyse the notification rate by age group. For example, in the EU/EEA, a sharp rise in gonorrhoea notification rate in young people, particularly women aged 20\u0026ndash;24 years, was observed in 2022-2023[20]. However, we could not examine if there was a similar change in non-EU/EEA due to a lack of age disaggregation. Similarly, due to the significantly limited data availability, it was not possible to analyse the mode of transmission. In the context of the scale-up of pre-exposure prophylaxis (PrEP) for HIV in non-EU/EEA[21], it is particularly important to monitor the incidence of STIs among key populations, such as men who have sex with men, as PrEP does not protect against other STIs than HIV and periodic testing for syphilis, gonorrhoea and chlamydia is strongly recommended by WHO[22]. Age and mode of transmission disaggregation are indispensable in revealing the accurate epidemics of STI transmissions and identifying specific populations who are most at risk for STIs to inform the policy about effective measures.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp; Another issue in surveillance systems was limited monitoring for antimicrobial-resistant gonorrhoea; a dedicated surveillance system has not been established in most countries. One country mentioned the usefulness of established collaboration with regional or international bodies. Considering the public health impact due to the possible spread of antimicrobial-resistant gonorrhoea, including multi-drug resistant gonorrhoea[23], this study showed the vulnerability of non-EU/EEA countries. The challenges countries mentioned mainly resulted from a lack of political commitment and resources. To rapidly detect antimicrobial-resistant gonorrhoea and prevent its further spread, a regional and global collaborative approach to support developing surveillance at the national level should be considered.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp; Taken together, non-EU/EEA countries share many common challenges in STI surveillance, and increased domestic and international support and the establishment of a coordinated international STI data reporting system are urgently needed to monitor and ensure that STI resources are used efficiently to control STIs in non-EU/EEA effectively.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp; The strength of this study is the high number of countries providing data, which enabled us to understand the overall picture of STI epidemics and identify common challenges in STI surveillance systems of this sub-region. At the same time, the data in this study should be interpreted in the light of several limitations. Firstly, a high heterogeneity between reporting countries in not only surveillance systems but also testing policies, access to STI testing, diagnostic techniques and reporting practices should be taken into account. Also, we did not define case definitions for the infections, and the countries used their own definitions. Possible heterogeneity in how the reported cases are defined should be considered. Second, this study is based on the responses from the countries, and no data in the collection form does not necessarily mean that there is no such data. Finally, considering the sub-regional context of high levels of stigma and discrimination[24]\u003csup\u003e,\u003c/sup\u003e[25] and suboptimal access to and quality of testing[26] along with the above-mentioned suboptimal surveillance systems, it is highly likely that the number of STI cases is underreported, and the real scale of the STI epidemic in non-EU/EEA can be bigger than reported.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eIn non-EU/EEA countries in the WHO European Region, the number of reported cases of syphilis and gonorrhoea increased between 2021 and 2023. At the same time, this study sheds light on the enormous challenges of STI surveillance in this subregion. Given the significant public health consequences of untreated STIs, an accelerated joint effort to strengthen the surveillance systems of the non-EU/ EEA countries is warranted to move towards ending epidemics of STIs in the WHO European Region by 2030.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eECDC\u0026nbsp;European Centre for Disease Prevention and Control\u003c/p\u003e\n\u003cp\u003eEU/EEA\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;European Union and European Economic Area\u003c/p\u003e\n\u003cp\u003eHIV\u0026nbsp; \u0026nbsp; \u0026nbsp;human immunodeficiency virus\u003c/p\u003e\n\u003cp\u003eLGV\u0026nbsp; \u0026nbsp;\u0026nbsp;lymphogranuloma venereum\u003c/p\u003e\n\u003cp\u003eSTIs\u0026nbsp; \u0026nbsp; \u0026nbsp;Sexually transmitted infections\u003c/p\u003e\n\u003cp\u003eWHO\u0026nbsp;\u0026nbsp;World Health Organization\u003c/p\u003e\n\u003cp\u003eWHO-GASP \u0026nbsp; WHO Gonococcal AMR Surveillance Programme\u0026nbsp;\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eEthics approval and consent to participate\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003eConsent for publication\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003eAvailability of data and materials\u003c/p\u003e\n\u003cp\u003eThe results of the surveys are available from the corresponding author upon reasonable request.\u003c/p\u003e\n\u003cp\u003eCompeting interests\u003c/p\u003e\n\u003cp\u003eAll authors declare no conflict of interest.\u003c/p\u003e\n\u003cp\u003eAuthors\u0026rsquo; contributions\u003c/p\u003e\n\u003cp\u003eMO led the data collection process, wrote the manuscript,\u0026nbsp;and generated tables and figures.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eJ.R., V.G., G.K., and S.B. contributed to the data collection, reviewed the manuscript and agreed on its final version.\u0026nbsp;WHO European Region non-EU/EEA STI Surveillance network members\u0026nbsp;contributed to the acquisition of data by participating in the surveys conducted by the authors.\u003c/p\u003e\n\u003cp\u003eAcknowledgement\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eWHO European Region non-EU/EEA STI Surveillance network members:\u003c/p\u003e\n\u003cp\u003eAlbania: Adela Vasili;\u003c/p\u003e\n\u003cp\u003eAndorra: Jennifer Fern\u0026aacute;ndez Garcia;\u003c/p\u003e\n\u003cp\u003eArmenia: Hovhannes Hovhannisyan;\u003c/p\u003e\n\u003cp\u003eAzerbaijan: Oleg Salimov;\u003c/p\u003e\n\u003cp\u003eBelarus:Hanna P. Muzychenka;\u003c/p\u003e\n\u003cp\u003eGeorgia: Khatuna Zakhashvili and Nino Lomia Israel;\u003c/p\u003e\n\u003cp\u003eIsrael: Rivka Rich;\u003c/p\u003e\n\u003cp\u003eKyrgyzstan: Elvira Torobekova;\u003c/p\u003e\n\u003cp\u003eMonaco: Thomas Althaus;\u003c/p\u003e\n\u003cp\u003eMontenegro: Alma Cicic and Milena Lopicic;\u003c/p\u003e\n\u003cp\u003eNorth Macedonia: Dragan Kochinski;\u003c/p\u003e\n\u003cp\u003eRepublic of Moldova: Aurelia Popov;\u003c/p\u003e\n\u003cp\u003eSan Marino: Claudio Muccioli;\u003c/p\u003e\n\u003cp\u003eSerbia: Danijela Simic;\u003c/p\u003e\n\u003cp\u003eSwitzerland: Jean-Luc Richard and Thibault Lovey;\u003c/p\u003e\n\u003cp\u003eTajikistan: Sakina Shoeva;\u003c/p\u003e\n\u003cp\u003eT\u0026uuml;rkiye: Taliha Karak\u0026ouml;k and Mehmet Balcı;\u003c/p\u003e\n\u003cp\u003eUkraine: Liudmila Polanska;\u003c/p\u003e\n\u003cp\u003eUzbekistan: Dilmurad Zhumanov.\u003c/p\u003e\n\u003cp\u003eThe views and opinions expressed in this paper are those of the authors and not necessarily the views, decisions or policies of the World Health Organization (WHO)\u003c/p\u003e\n\u003cp\u003eFunding\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData sharing statement\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll available data collected in this study can be shared upon reasonable request after acquiring approval from the respective countries. \u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eWorld Health Organization (WHO), \u0026ldquo;Global health sector strategies on, respectively, HIV, viral hepatitis and sexually transmitted infections for the period 2022\u0026ndash;2030,\u0026rdquo; 2022. https://iris.who.int/handle/10665/338901\u003c/li\u003e\n\u003cli\u003eM. C. Boily \u003cem\u003eet al.\u003c/em\u003e, \u0026ldquo;Heterosexual risk of HIV-1 infection per sexual act: a systematic review and meta-analysis of observational studies,\u0026rdquo; \u003cem\u003eLancet. Infect. Dis.\u003c/em\u003e, vol. 9, no. 2, p. 118, Feb. 2009, doi: 10.1016/S1473-3099(09)70021-0.\u003c/li\u003e\n\u003cli\u003eWorld Health Organization (WHO), \u0026ldquo;Global progress report on HIV, viral hepatitis and sexually transmitted infections, 2021,\u0026rdquo; 2021.\u003c/li\u003e\n\u003cli\u003eWorld Health Organization (WHO) Regional Office for Europe, \u0026ldquo;Regional action plans for ending AIDS and the epidemics of viral hepatitis and sexually transmitted infections 2022\u0026ndash;2030,\u0026rdquo; Copenhagen, 2023.\u003c/li\u003e\n\u003cli\u003eWorld Health Organization (WHO), \u0026ldquo;Implementing the global health sector strategies on HIV, viral hepatitis and sexually transmitted infections, 2022\u0026ndash;2030: report on progress and gaps 2024,\u0026rdquo; 2024.\u003c/li\u003e\n\u003cli\u003eEuropean Centre for Disease Prevention and Control, \u0026ldquo;Syphilis - Annual Epidemiological Report 2023,\u0026rdquo; 2025. [Online]. Available: https://www.ecdc.europa.eu/en/publications-data/syphilis-annual-epidemiological-report-2023\u003c/li\u003e\n\u003cli\u003eEuropean Centre for Disease Prevention and Control and WHO Regional Office for Europe, \u0026ldquo;Gonorrhoea - Annual Epidemiological Report for 2023,\u0026rdquo; 2025. [Online]. Available: https://www.ecdc.europa.eu/en/publications-data/gonorrhoea-annual-epidemiological-report-2023\u003c/li\u003e\n\u003cli\u003eEuropean Centre for Disease Prevention and Control, \u0026ldquo;Chlamydia - Annual Epidemiological Report for 2023,\u0026rdquo; 2025. [Online]. Available: https://www.ecdc.europa.eu/en/publications-data/chlamydia-annual-epidemiological-report-2023\u003c/li\u003e\n\u003cli\u003eEuropean Centre for Disease Prevention and Control, \u0026ldquo;Lymphogranuloma venereum - Annual Epidemiological Report for 2023,\u0026rdquo; 2025. [Online]. 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Medland \u003cem\u003eet al.\u003c/em\u003e, \u0026ldquo;Surveillance systems to monitor antimicrobial resistance in Neisseria gonorrhoeae: a global, systematic review, 1 January 2012 to 27 September 2020,\u0026rdquo; \u003cem\u003eEurosurveillance\u003c/em\u003e, vol. 27, no. 18, 2022, doi: 10.2807/1560-7917.ES.2022.27.18.2100917.\u003c/li\u003e\n\u003cli\u003eUnited Nations Department of Economic and Social Affairs, \u0026ldquo;World Population Prospects 2024,\u0026rdquo; 2024. https://population.un.org/wpp/ (accessed Oct. 01, 2024).\u003c/li\u003e\n\u003cli\u003eEuropean Centre for Disease Prevention and Control, \u0026ldquo;Surveillance Atlas of Infectious Diseases.\u0026rdquo; https://atlas.ecdc.europa.eu/public/index.aspx (accessed Jan. 24, 2025).\u003c/li\u003e\n\u003cli\u003eWorld Health Organization (WHO), \u0026ldquo;Chlamydia Key facts,\u0026rdquo; 2024. https://www.who.int/news-room/fact-sheets/detail/chlamydia\u003c/li\u003e\n\u003cli\u003eM. J. 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Escobar, and J. D. Fortenberry, \u0026ldquo;The role of sexually transmitted infections (STI) prevention and control programs in reducing gender, sexual and STI-related stigma,\u0026rdquo; \u003cem\u003eEClinicalMedicine\u003c/em\u003e, vol. 33, p. 100764, 2021, doi: 10.1016/j.eclinm.2021.100764.\u003c/li\u003e\n\u003cli\u003eA. Uusk\u0026uuml;la, K. Kangur, and L. A. McNutt, \u0026ldquo;Barriers to effective STI screening in a post-Soviet society: Results from a qualitative study,\u0026rdquo; \u003cem\u003eSex. Transm. Infect.\u003c/em\u003e, vol. 82, no. 4, pp. 323\u0026ndash;326, 2006, doi: 10.1136/sti.2005.019000.\u003c/li\u003e\n\u003cli\u003eI. Boiko, I. Krynytska, I. Kohut, H. Bezkorovaina, and V. Stepanenko, \u0026ldquo;Diagnostics of Gonococcal Infection in Ukraine: Current Challenges in Resource-Constrained Settings,\u0026rdquo; \u003cem\u003eEurasian J. Med.\u003c/em\u003e, vol. 53, no. 3, p. 180, Oct. 2021, doi: 10.5152/EURASIANJMED.2021.20043.\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-public-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"pubh","sideBox":"Learn more about [BMC Public Health](http://bmcpublichealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/pubh/default.aspx","title":"BMC Public Health","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Sexually transmitted infection, Syphilis, Gonorrhoea, Chlamydia, Lymphogranuloma venereum, Europe, Central Asia","lastPublishedDoi":"10.21203/rs.3.rs-6093564/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6093564/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eSexually transmitted infections (STIs) continue to be a significant public health challenge and have an impact on sexual and reproductive health. European Union and European Economic Area (EU/EEA) countries report data annually on the number of cases of syphilis, gonorrhoea, chlamydia, and lymphogranuloma venereum (LGV) to the European Centre for Disease Prevention and Control. No similar system exists for the non-EU/EEA countries in the WHO European Region, and therefore, the sub-regional overview was unclear due to the limited data availability and inconsistency.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eWe conducted a survey among 24 WHO member states in the WHO European Region that did not belong to the EU/EEA as of June 2024. The survey collected data on STI surveillance systems and numbers of reported cases of syphilis, gonorrhoea, chlamydia and LGV from 2021 to 2023.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eTwenty-one completed the survey, of which 19 (79%) agreed to publish their data. All 19 countries reported surveillance activities for syphilis, 18 for gonorrhoea and chlamydia, and 8 for LGV. The comprehensiveness and coverage of surveillance systems varied between countries and infections. Total cases reported increased from 13,553 to 17,113 (notification rate per 100,000 population 5.4 to 6.9) for syphilis and 12,001 to 13,067 (4.2 to 5.0) for gonorrhoea between 2021 and 2023, while chlamydia cases decreased from 32,556 to 27,802 (13.3 to 11.2). Only one to two LGV cases were reported per year. Various challenges were identified in antimicrobial-resistant gonorrhoea surveillance.\u003c/p\u003e\u003ch2\u003eConclusions\u003c/h2\u003e \u003cp\u003eIn non-EU/EEA countries, STI cases are likely to be underreported due to incomplete surveillance systems and other factors. Given the increase in the number of reported cases of syphilis and gonorrhoea between 2021 and 2023 and the significant public health consequences of untreated STIs, an accelerated joint effort to strengthen the surveillance systems of the non-EU/EEA countries is warranted to move towards ending epidemics of STIs in the WHO European Region by 2030.\u003c/p\u003e","manuscriptTitle":"Sexually Transmitted Infections in the non-European Union and European Economic Area of the World Health Organization European Region 2021-2023","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-03-17 18:42:00","doi":"10.21203/rs.3.rs-6093564/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2025-02-27T10:00:39+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-02-25T22:27:32+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-02-25T22:26:20+00:00","index":"","fulltext":""},{"type":"submitted","content":"BMC Public Health","date":"2025-02-24T05:48:28+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-public-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"pubh","sideBox":"Learn more about [BMC Public Health](http://bmcpublichealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/pubh/default.aspx","title":"BMC Public Health","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"7e870b79-85c5-4bed-8969-b4aafd0fa5f3","owner":[],"postedDate":"March 17th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2025-04-28T16:06:02+00:00","versionOfRecord":{"articleIdentity":"rs-6093564","link":"https://doi.org/10.1186/s12889-025-22630-6","journal":{"identity":"bmc-public-health","isVorOnly":false,"title":"BMC Public Health"},"publishedOn":"2025-04-25 15:57:53","publishedOnDateReadable":"April 25th, 2025"},"versionCreatedAt":"2025-03-17 18:42:00","video":"","vorDoi":"10.1186/s12889-025-22630-6","vorDoiUrl":"https://doi.org/10.1186/s12889-025-22630-6","workflowStages":[]},"version":"v1","identity":"rs-6093564","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6093564","identity":"rs-6093564","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}