Analysis of Six Bone-Derived Factors in Plasma and CSF of Chinese Patients with Parkinson's Disease

Background: Parkinson's disease (PD) has a close relationship with osteoporosis and bone secretory proteins may be involved in disease progress. Objectives: To detect the six bone-derived factors in plasma and CSF of patients with PD and evaluate their correlations with CRP level, motor impairment and HY stage of the disease. Methods: : We included 250 PD patients and 250 controls. Levels of OCN, OPN, OPG, SO, BMP2 and DKK-1 in Plasma and CSF were measured by custom protein antibody arrays. Data were analyzed using Mann-Whitney U-test and Spearman’s rank correlation. Results: : Plasma levels of OCN and OPN were correlated with CRP level and HY stage and motor impairment of PD. Furthermore, the plasma assessment with CSF detection may enhance their potential prediction on PD. Conclusions: : OCN and OPN may serve as potential biomarkers for PD. The inflammation response may be involved in the cross-talks between the two factors and PD.