Upgraded valorization of copper (II) immobilization onto Schiff base-functionalized pectin grafted magnetic nanoparticles: A thermostable, reusable, and efficient nanocatalyst for the green synthesis of 1,2,3-triazole in pure water

Upgraded valorization of copper (II) immobilization onto Schiff base-functionalized pectin grafted magnetic nanoparticles: A thermostable, reusable, and efficient nanocatalyst for the green synthesis of 1,2,3-triazole in pure water | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Upgraded valorization of copper (II) immobilization onto Schiff base-functionalized pectin grafted magnetic nanoparticles: A thermostable, reusable, and efficient nanocatalyst for the green synthesis of 1,2,3-triazole in pure water Hossein Khashei Siuki, Pouya Ghamari Kargar, Ghodsieh Bagherzade This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-775331/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract In this project, the new catalyst copper defines as Fe 3 O 4 @Pectin@(CH 2 ) 3 -Acetamide-Cu(II) was successfully manufactured and fully characterized by different techniques, including FT-IR, XRD, TEM, FESEM, EDX, VSM, and ICP analysis. All results showed that copper was successfully supported on the polymer‐coated magnetic nanoparticles. One of the most important properties of a catalyst is the ability to be prepared from simple materials such as pectin that’s a biopolymer that is widely found in nature. The catalytic activity of Fe 3 O 4 @Pectin@(CH 2 ) 3 -Acetamide-Cu(II) was examined in a classical, one pot, and the three-component reaction of terminal alkynes, alkyl halides, and sodium azide in water and observed, proceeding smoothly and completed in good yields and high regioselectivity. The critical potential interests of the present method include high yields, recyclability of catalyst, easy workup, using an eco-friendly solvent, and the ability to sustain a variety of functional groups, which give economical as well as ecological rewards. The capability of the nanocomposite was compared with previous works, and the nanocomposite was found more efficient, economical, and reproducible. Also, the catalyst can be easily removed from the reaction solution using an external magnet and reused for five runs without reduction in catalyst activity. Organic Chemistry Inorganic Chemistry Catalysis General Biochemistry Click reaction Heterogeneous catalyst Magnetic nanoparticles Pectin Polymer Triazole Full Text Declaration Competing interests: The authors declare no competing interests. Supplementary Files SupportingInformation.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-775331","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":43285052,"identity":"95386b69-5cbb-480b-9872-5581c4d9563f","order_by":0,"name":"Hossein Khashei Siuki","email":"","orcid":"","institution":"University of birjand","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Hossein","middleName":"Khashei","lastName":"Siuki","suffix":""},{"id":43319954,"identity":"29284fc8-0d12-4847-a2fc-d44bd8bcb2e7","order_by":1,"name":"Pouya Ghamari Kargar","email":"","orcid":"https://orcid.org/0000-0002-6284-2874","institution":"University of birjand","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Pouya","middleName":"Ghamari","lastName":"Kargar","suffix":""},{"id":43319955,"identity":"4f9152ee-a6e8-4316-a9d5-9380d5e10596","order_by":2,"name":"Ghodsieh Bagherzade","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABE0lEQVRIiWNgGAWjYBACAwYGNgjrAA/jYyCXGSLIwMBDjBZmY5K1sEkjBPEAc/bj1x583FMnz3e891h1QcE9dv7ZzRsYftQwyJg3YNdi2ZNTbjjjGZvhzDPn0m7PMChmlrhzrICx5xgDj8wBHA47kJMmzQP0+oYbOWa3eQwSmBlu5Bgw8DYw8Ejg8sv5N2nSfw5I2G+4/8asGKRFHqiF8S8+LTfSj0kzHDBI3HCDx4wZpMUAqIUZny2WM96wSfYcSEieeSbHWHoGUIvhjbSCwzLHJHBqMedPfybx40Cdbd/xM4afC/4kJMvdSN748E2NjT0uLcAoQ42FZBBxgIEBtwYGBvYHKFw7PEpHwSgYBaNghAIAgXtX6k43YW4AAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0003-2931-8146","institution":"University of birjand","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Ghodsieh","middleName":"","lastName":"Bagherzade","suffix":""}],"badges":[],"createdAt":"2021-08-02 08:34:55","currentVersionCode":1,"declarations":{"humanSubjects":false,"vertebrateSubjects":false,"conflictsOfInterestStatement":true,"humanSubjectEthicalGuidelines":false,"humanSubjectConsent":false,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false,"coiExplicitlySet":false},"doi":"10.21203/rs.3.rs-775331/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-775331/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":13664515,"identity":"ac74a143-a696-4e16-b51f-66e9c15f78a9","added_by":"auto","created_at":"2021-09-17 10:41:38","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1842071,"visible":true,"origin":"","legend":"","description":"","filename":"Article.pdf","url":"https://assets-eu.researchsquare.com/files/rs-775331/v1_covered.pdf"},{"id":12076323,"identity":"399b43ca-1fa2-4809-bda5-bf6567bde930","added_by":"auto","created_at":"2021-08-03 18:14:57","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1838544,"visible":true,"origin":"","legend":"","description":"","filename":"Article.pdf","url":"https://assets-eu.researchsquare.com/files/rs-775331/v1_covered.pdf"},{"id":12076308,"identity":"b6cb8b6d-aa42-4e68-9419-3c0720033159","added_by":"auto","created_at":"2021-08-03 18:14:39","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":3350556,"visible":true,"origin":"","legend":"","description":"","filename":"SupportingInformation.pdf","url":"https://assets-eu.researchsquare.com/files/rs-775331/v1/7058f10ca3f4e11ca2a6f120.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003eUpgraded valorization of copper (II) immobilization onto Schiff base-functionalized pectin grafted magnetic nanoparticles: A thermostable, reusable, and efficient nanocatalyst for the green synthesis of 1,2,3-triazole in pure water\u003c/p\u003e","fulltext":[{"header":"Full Text","content":"This preprint is available for \u003ca href='/article/rs-775331/latest.pdf' target='_blank'\u003edownload as a PDF\u003c/a\u003e."},{"header":"Declaration","content":"\u003cp\u003eCompeting interests: The authors declare no competing interests.\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"University of Birjand","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Click reaction, Heterogeneous catalyst, Magnetic nanoparticles, Pectin, Polymer, Triazole","lastPublishedDoi":"10.21203/rs.3.rs-775331/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-775331/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eIn this project, the new catalyst copper defines as Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@Pectin@(CH\u003csub\u003e2\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e-Acetamide-Cu(II) was successfully manufactured and fully characterized by different techniques, including FT-IR, XRD, TEM, FESEM, EDX, VSM, and ICP analysis. All results showed that copper was successfully supported on the polymer‐coated magnetic nanoparticles. One of the most important properties of a catalyst is the ability to be prepared from simple materials such as pectin that’s a biopolymer that is widely found in nature. The catalytic activity of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@Pectin@(CH\u003csub\u003e2\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e-Acetamide-Cu(II) was examined in a classical, one pot, and the three-component reaction of terminal alkynes, alkyl halides, and sodium azide in water and observed, proceeding smoothly and completed in good yields and high regioselectivity. The critical potential interests of the present method include high yields, recyclability of catalyst, easy workup, using an eco-friendly solvent, and the ability to sustain a variety of functional groups, which give economical as well as ecological rewards. The capability of the nanocomposite was compared with previous works, and the nanocomposite was found more efficient, economical, and reproducible. Also, the catalyst can be easily removed from the reaction solution using an external magnet and reused for five runs without reduction in catalyst activity.\u003c/p\u003e","manuscriptTitle":"Upgraded valorization of copper (II) immobilization onto Schiff base-functionalized pectin grafted magnetic nanoparticles: A thermostable, reusable, and efficient nanocatalyst for the green synthesis of 1,2,3-triazole in pure water","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-08-03 18:14:37","doi":"10.21203/rs.3.rs-775331/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"8c1ec59c-e0f7-402c-a097-f0d534a858ed","owner":[],"postedDate":"August 3rd, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":6162985,"name":"Organic Chemistry"},{"id":6162986,"name":"Inorganic Chemistry"},{"id":6162987,"name":"Catalysis"},{"id":6162988,"name":"General Biochemistry"}],"tags":[],"updatedAt":"2021-08-03T18:14:37+00:00","versionOfRecord":[],"versionCreatedAt":"2021-08-03 18:14:37","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-775331","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-775331","identity":"rs-775331","version":["v1"]},"buildId":"FbvkV6FR0MCFSLy54lSbu","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}