Expression of estrogen receptor and progesterone receptor gene in endometrium of rats with endometriosis

AIM: The purpose of this study was to explore the expression of estrogen receptor(ER) and progesterone receptor(PR) mRNA in endometrium of rats with endometriosis. METHODS: The rat model of endometriosis was established, and the expression of ER, PR mRNA in the endometrium was examined by reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: The expression of ER and PR mRNA in ectopic endometrium was significantly lower than that in eutopic and normal endometrium (P0.01). No difference was observed between eutopic and normal endometium (P0.05). Ratio of ER/PR mRNA in eutopic endometrium was higher than that in eutopic and in normal endometrium (P0.01). CONCLUSION: It is suggested that the increased ER may play a vital role in the onset of endometriosis.