Molecular effects of plasma acid on the ovarian endometrioma capsule tissue

В. В. Салмин, T. A. Perevertov, G. A. Muradyan, E. S. Gudkova, A. S. Epova, V.A. Kutyakov, Krasnoyarsk Regional Bureau of Forensic Medicine, E. V. Lychkovskaya, Т. Н. Чекишева, N. A. Malinovskaya, Н. Н. Медведева, Т. А. Макаренко, А. Б. Салмина
In: Siberian Medical Review · 2022 · vol. 4 , pp. 73–82 · doi:10.20333/25000136-2022-4-73-82 · W4294837951
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This study investigated the effects of plasma-treated water on ovarian endometrioma cyst wall tissue in vitro, finding it more ablative and apoptogenic than ethanol with decreased neoangiogenesis and protein damage.

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Abstract

The aim of the research. To study the molecular effects of water treated with spark-discharge plasma on tissues of the cyst wall of the ovarian endometrium in vitro. Material and methods. Tissues of the ovarian endometrial cyst capsule obtained during the surgical treatment of women through laparoscopic access were incubated in various modes in plasma acid, ethanol and physiological solution at room temperature. Plasma acid was produced by treating water for injection with spark-discharge plasma to a decrease in pH<2.0. Aft er the immunohistochemical study of the preparations, a comparative analysis of ablative and apoptogenic action via TUNEL was performed, as well as analysis of proangiogenic action (VEGFA), endothelial progenitor cells (CD133), protein damage (NT), DNA damage (8-OHdG) and proliferation activity (Ki67) of different treatment methods from the standpoint of potential plasma acid efficacy for sclerotherapy of ovarian endometrioma as compared to standard sclerosant: ethanol. Results. Th e study has demonstrated a more pronounced ablation and pre-apoptogenic effect of plasma acid on tissues of the ovarian endometrium capsule than ethanol. In addition, a decrease in neoangiogenesis and protein damage from active forms of nitrogen (protective action) compared to ethanol was shown. Conclusion. Water treated with spark-discharge plasma can be considered an eff ective alternative to ethanol for ovarian endometrioma sclerotherapy. The sequential action of plasma acid and ethanol increases the sclerosing action of ethanol.

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endometrioma

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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