Performance evaluation of femtosecond laser processed natural bioremediation membranes

Abstract Background Natural bioremediation membranes are excellent materials for skin repair. Traditional mechanical processing methods have limitations, including low processing speed and heat accumulation. Therefore, scholars have proposed the femtosecond laser as a novel processing technique to improve processing speed, accuracy, and quality at the same time reducing the heat effect. Methods In this study, a smoother and flatter surface without carbonization was obtained by optimizing the laser parameters, then compared with mechanical processing in terms of physicochemical properties and biocompatibility. Results The results revealed consistent physicochemical properties of the femtosecond laser interface with wound dressing requirements; moreover, the collagen biocompatibility remained preserved, which was beneficial to the adhesion and proliferation of human dermal fibroblasts. Conclusions Therefore, this work validates the feasibility of femtosecond laser in processing natural bioremediation membranes and addresses the challenges of slow processing speed, low precision, and heat accumulation predominant in conventional processing methods. The findings not only provide insights and methods for processing natural bioremediation membranes but also other medical regenerative materials.