Case Report of Angiocentric Glioma Lacking Epilepsy and Discuss Its Relationship With Epilepsy

Background: Angiocentric glioma is a rare neuro tumor, the general public believes that the typical clinical feature of angiocentric glioma (AG) is a history of epilepsy. This case have unique research value because it is lack history of epilepsy, it is provide evidence to exploration of the causes of AG-related epilepsy symptoms. Case presentations: A 16-year-old boy came to the hospital because of dizziness and blurred vision. The patient's CT stan detected a solid mass in the right frontotemporal lobe. Histologic finding the tumor is predominantly composed of elongated tumor cells forming rings around the blood vessels, the immunohistochemical staining show GFAP、D2-40、S100、Vimentin have positive expression, and Ki-67 proliferation index is 1%~5%, FISH-tissue show MYB gene rearrangement detection. According these evidences, this case was diagnosed as angiocentric glioma. the patient's physical condition was stable and there was no recurrence after the operation. Conclusion: We believe that MYB gene break rearrangement is related to the cause of AG and MYB-QKI gene rearrangement may be one of the important causes of AG, but it is not directly related to AG-related epilepsy.