Comment on ‘Initiation of chromosome replication controls both division and replication cycles inE. colithrough a double-adder mechanism’

Witz et al . recently performed single-cell mother machine experiments to track growth and the replication cycle in E. coli . They analyzed the correlation structure of selected parameters using both their data and published data, and concluded that E. coli cell-size control is implemented at replication initiation, which challenged the newly emerged division-centric mechanism of cell-size control in bacteria. We repeated Witz et al.’s analysis, and performed additional experiments and analytical calculations. These results explain Witz et al.’s observation and in fact support the division-centric model.