Effective analysis of platelet transfusion dose in hematological pediatric patients with thrombocytopenia：A single center retrospective cohort study

Background: Platelet transfusion is a common method to prevent hemorrhage in hematological pediatric patients. There is a shortage of platelet resources in many district of China. Small-dose platelet transfusion may be an effective measure to solve these problems. Methods: A retrospective analysis of platelet transfusion in 96 hematological pediatric patients with thrombocytopenia. According to the actual platelet dosage transfused, we divided the cases into two groups: low-dose platelet transfusion group (<3.0×10^11 platelet/m2, LDC, n=109) and high-dose platelet transfusion group (≥3.0×10^11 platelet/m2, HDC, n=90). To evaluate the effect of platelet transfusion, we assessed the post-transfusion platelet increment (PPI) values, changes of hemoglobin after platelet transfusion and calculated the corrected count increment (CCI) at 24h after transfusion between the two groups. We also recorded adverse reactions during transfusion. Results: Through statistical analysis, we found that there was no statistical difference in the 24h CCI value, hemoglobin change value and the effective rate of platelet transfusion between LDC and HDC groups. There was no adverse reaction in the LDC group, but 1 adverse reaction case in the HDC group. Conclusion: Low dose platelet transfusion is effective in pediatric patients with thrombocytopenia.