Morphokinetic parameters of early embryo development.

A) The mixed-model analysis revealed a significant main effect of time (p<0.001) with post-hoc tests showing that any time needed to reach a specific developmental stage was significantly different from all the others (all p<0.001). Embryos of endometriosis patients showed the same absolute morphokinetic parameters as the control group. B) Subgroup analysis of the different stages of endometriosis and the control group also revealed a significant main effect of time (p<0.001). Looking at the significant overall interaction effect (time*group, p<0.01) more in detail, embryos of severe endometriosis patients reached t9 faster than patients with minimal or moderate endometriosis as well as the control group (all p<0.01). Time gain equalized again at tMor. Data are shown as mean predicted values [95% CI].