Blockade of dopamine D4 receptors in the paraventricular nucleus of the hypothalamus inhibits food intake and behavioral satiety sequence in rats

Blockade of dopamine D4 receptors in the paraventricular nucleus of the hypothalamus inhibits food intake and behavioral satiety sequence in rats | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 17 February 2025 V1 Latest version Share on Blockade of dopamine D4 receptors in the paraventricular nucleus of the hypothalamus inhibits food intake and behavioral satiety sequence in rats Authors : Refugio Cruz-Trujillo , Juan Gabriel Tejas-Juarez , Juan Mancilla-Diaz , Veronica Lopez-Alonso , Hector Esquinca-Aviles , and Rodrigo Erick Escartin Perez 0000-0002-4426-6260 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.173981750.08070751/v1 324 views 117 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract With the escalating global prevalence of obesity, understanding eating behavior is an imperative focus of research. Emerging evidence underscores the central role of dopamine and its receptors in normal and pathological regulation of food intake. Investigations have confirmed the stimulatory effect of selective activation of D4 dopamine receptors within the paraventricular nucleus of the hypothalamus on food intake. This leads to the hypothesis that perturbations in hypothalamic dopaminergic signaling pathways that regulate energy homeostasis may potentially underlie the propensity for obesity-related excess caloric consumption via a D4 Receptor-mediated mechanism. This study aims to elucidate the effects of central administration of the D4 receptor antagonist, L-745,870, on regulating food intake, satiety, and locomotor activity. Here, we investigated the impact of intra-paraventricular blockade of D4 receptors on standard food consumption, behavioral satiety sequence, and locomotor activity in male Wistar rats. Our results indicate that injection of L-745,870 at doses of 0.1 and 1 µg induces a significant reduction in standard food intake within sixty minutes of administration. At a dose of 0.1 µg, L-745,870 accelerated the onset of postprandial satiety without a significant effect on locomotor activity. Together, our results highlight the central role of D4 receptors in the modulation of feeding behavior and satiety and provide a potential avenue for using this compound for the development of pharmacological interventions for obesity. The demonstrated efficacy of L-745,870 in reducing food intake supports its potential therapeutic utility in the broader context of obesity management. Supplementary Material File (cruztrujilloetal.docx) Download 1.09 MB File (table1.docx) Download 69.82 KB Information & Authors Information Version history V1 Version 1 17 February 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords dopamine antagonist food intake regulation obesity paraventricular hypothalamus Authors Affiliations Refugio Cruz-Trujillo UNACH View all articles by this author Juan Gabriel Tejas-Juarez UJAT View all articles by this author Juan Mancilla-Diaz Universidad Nacional Autónoma de México Facultad de Estudios Superiores Iztacala View all articles by this author Veronica Lopez-Alonso Universidad Nacional Autónoma de México Facultad de Estudios Superiores Iztacala View all articles by this author Hector Esquinca-Aviles UNACH View all articles by this author Rodrigo Erick Escartin Perez 0000-0002-4426-6260 [email protected] Universidad Nacional Autónoma de México Facultad de Estudios Superiores Iztacala View all articles by this author Metrics & Citations Metrics Article Usage 324 views 117 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Refugio Cruz-Trujillo, Juan Gabriel Tejas-Juarez, Juan Mancilla-Diaz, et al. Blockade of dopamine D4 receptors in the paraventricular nucleus of the hypothalamus inhibits food intake and behavioral satiety sequence in rats. Authorea . 17 February 2025. DOI: https://doi.org/10.22541/au.173981750.08070751/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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