Biocomputational Analysis Establishes Genetic Association of Rheumatoid Arthritis (RA) and Migraine

ABSTRACT An autoimmune disease and a neurological disease do not tie up together but if statistics say that 61% of people are affected by Rheumatoid Arthritis (an autoimmune disease) and Migraine (a neurological disease) at the same time it is really a point to be noted. The previous studies show that Rheumatoid Arthritis (RA) and Migraine are related anatomically but our goal was to dig out any other similarities except it. Therefore, we studied their genes and hoped to get something fascinating. We assessed the genes from the literature study and Genetic Home Reference ( https://ghr.nlm.nih.gov/ ). After that, the genetic sequences of these genes were extracted from NCBI (National Center for Biotechnology Information, http://ncbi.nlm.nih.gov ) and by applying multiple sequence alignment, we created a phylogenetic tree by Mega (Molecular Evolutionary Genetics Analysis). Surprisingly, we found 10 pairs of genes with similar genetic structures and common ancestry. Therefore, we can say these 10 pairs of genes are related to each other closely, which is why Migraine and Rheumatoid Arthritis (RA) are found together in a person. At the last part of this study, we used protein expression for the evaluation of the result. Here our bioinformatics approach may help to strengthen the connectedness of these two diverse diseases.