Preparation of PLA / Chitosan Nanoscaffolds Containing Cod Liver Oil and Experimental Diabetic Wound Healing in Male Rats Study

Abstract Background Diabetes mellitus is one of the most common metabolic disorders. One of the important metabolic complications in diabetes is diabetic foot ulcer syndrome, which causes delayed and abnormal healing of the wound. The formulation of nanoscaffolds containing cod liver oil by altering the hemodynamic balance toward the vasodilators state, increasing wound blood supply, and altering plasma membrane properties, namely altering the membrane phospholipids composition can be effective in wound healing. In this study electrospinning method was used to produce poly lactic acid/chitosan nanoscaffolds as a suitable bio substitute. Results The results showed that the optimum formulation of cod liver oil was 30%, which formed a very thin fiber that rapidly absorbed to the wound and produced significant healing effects. According to the results poly lactic acid / chitosan nanoscaffolds containing cod liver oil can be a suitable bio product to use in the treatment of diabetic foot ulcer syndrome. Conclusions The poly lactic acid / chitosan nanoscaffolds containing 30% cod liver oil show more healing and less wound area on the fourteenth day which this can be due to permeability and sufficient oxygen for tissue repair. Moisture retention of the wound medium to accelerate its healing, color change and pH changes to keep the wound site safe from bacteria, contamination and non-contamination are among the characteristics of the nanoscaffold produced.