Peripheral Blood Transcriptome Profiles of Adults with Type I Hypersensitivity

Allergy of type I hypersensitivity affects about 150 million people in Europe. It is clinically manifested as atopic dermatitis, conjunctivitis, rhinitis, rhinoconjunctivitis, and allergic asthma. However, the underlying mechanisms occurring at the gene expression level remain poorly understood. To address this gap, the transcriptome of peripheral blood cells from participants with type I hypersensitivity symptoms was measured to gain insights into mechanisms underlying the disease. We examined immunological pathways of observed transcriptomic profiles to examine immune-related alterations in participants with atopic disorders. A diverse array of enriched pathways and cellular processes associated with type I hypersensitivity reactions were identified within domains such as antigen-presenting cells (APCs), interleukins, mast cells, CD molecules, T helper (Th) and T regulator (Treg) cells, and B cells. These findings collectively suggest that disturbances at the gene expression level contribute to immunological disorders in individuals experiencing allergic manifestations.