The Oncogenic Role of AXIN1 In Human Tumors: A Pan-Cancer Analysis of AXIN1.

Background: Although emerging cell- or animal-based evidence supports the correlation between AXIN1(Axis inhibition protein 1) and cancers，no pan-cancer analysis is accessible. Method: We thus investigate the possible oncogenic characters of AXIN1 by 33 tumor types based on the datasets of TCGA (The cancer genome atlas) and GEO (Gene expression omnibus). Result: AXIN1 has a high expression in lots of tumors, and obvious relevance between AXIN1 expression and prognosis of cancer patients, such as LICH (Liver hepatocellular carcinoma) and breast cancer. We observed an increase phosphorylation level of S486/S493 in breast cancer and UCEC (Uterine Corpus Endometrial Carcinoma). AXIN1 expression shows a correlation with T cell regulatory in several cancers such as LIHC and LUAD (Lung adenocarcinoma). Furthermore, enrichment exist between Wnt signaling pathway, Hippo signaling pathway and pathways in cancer and the functional mechanisms of AXIN1. Conclusions: : Our first pan-cancer study provides a relatively complete interpretation of oncogenic characters of AXIN1 though different tumors.