Cancer: A Comprehensive Review

Cancer: A Comprehensive Review | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 20 August 2025 V1 Latest version Share on Cancer: A Comprehensive Review Author : Shobith Suresh 0000-0001-6336-1418 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.175571721.15408316/v1 284 views 164 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Cancer remains one of the most formidable challenges in medicine, representing a multifactorial disease characterized by uncontrolled cellular proliferation, invasion, and metastasis. Over the past century, cancer research has transitioned from descriptive pathology to a molecularly defined science, driven by advances in genomics, proteomics, immunology, and clinical oncology. The disease is not a single entity but a collection of disorders with distinct molecular signatures, etiologies, and clinical manifestations. This review provides a comprehensive exploration of cancer, beginning with its historical discovery and classification, followed by an in-depth discussion of stages, molecular biology, immunological interactions, and tumor escape mechanisms. The review further elaborates on the clinical aspects including etiology, symptoms, epidemiology, diagnosis, prophylaxis, treatment, and management. Importantly, newer technologies such as immunotherapy, nanomedicine, liquid biopsy, and CRISPR-based therapeutics are discussed as transformative approaches in oncology. Through the integration of fundamental biology with translational advances, this review aims to provide an up-to-date understanding of cancer pathophysiology and clinical management, highlighting both achievements and persisting challenges in global cancer control (Hanahan and Supplementary Material File (cancer (1).pdf) Download 185.59 KB Information & Authors Information Version history V1 Version 1 20 August 2025 Copyright This work is licensed under a Creative Commons Attribution 4.0 International License Keywords cancer cancer management cancer vaccines crispr immunology immunotherapy liquid biopsy molecular biology nanomedicine oncology precision oncology targeted therapy tumor microenvironment tumorigenesis Authors Affiliations Shobith Suresh 0000-0001-6336-1418 [email protected] Jawaharlal Nehru Centre for Advanced Scientific Research View all articles by this author Metrics & Citations Metrics Article Usage 284 views 164 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Shobith Suresh. Cancer: A Comprehensive Review. Authorea . 20 August 2025. DOI: https://doi.org/10.22541/au.175571721.15408316/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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