Proinflammatory and Prothrombotic Conditions in JAK2V617F-Positive MPN: A Case of Lemierre’s Syndrome in Essential Thrombocythemia

Proinflammatory and Prothrombotic Conditions in JAK2V617F-Positive MPN: A Case of Lemierre’s Syndrome in Essential Thrombocythemia | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Proinflammatory and Prothrombotic Conditions in JAK2V617F-Positive MPN: A Case of Lemierre’s Syndrome in Essential Thrombocythemia Takuya Izumi, Kosuke Takano, Shigeki Nagao, Noriaki Tachi, Sho Sato, and 10 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5416591/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 20 Mar, 2025 Read the published version in Annals of Hematology → Version 1 posted 8 You are reading this latest preprint version Abstract Lemierre’s syndrome (LS) represents a rare yet potentially life-threatening systemic infection, characterized by thrombophlebitis of the internal jugular vein and abscess formation in distant organs. It typically follows episodes of tonsillitis or other infections of the oropharyngeal region. Pulmonary complications, including septic pulmonary emboli, are common. Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm (MPN) sometimes associated with the JAK2V617F mutation, which predisposes patients to thrombotic events. A 66-year-old male with JAK2V617F-positive ET presented with severe pulsatile pain radiating from the right temporal region to the occipital area following a recent dental infection. Although pain management was administered, the pain continued to persist. Computed tomography of the chest revealed multiple subpleural nodules, raising suspicion for septic pulmonary emboli. Further investigation with gadolinium-enhanced magnetic resonance imaging identified a thrombus extending from the right sigmoid sinus into the internal jugular vein, consistent with cerebral venous thrombosis. The patient was diagnosed with LS, complicated by septic thrombosis. Blood cultures yielded alpha-hemolytic streptococcus. Empirical antimicrobial therapy combined with anticoagulation was initiated, resulting in a gradual improvement of symptoms, including the resolution of fever and pain. Follow-up imaging confirmed the resolution of both the infection and thrombosis. This is the first reported case of LS in a patient with JAK2V617F-positive ET. The coexistence of LS and JAK2V617F-positive MPN highlights the potential interplay between proinflammatory and prothrombotic conditions associated with the JAK2V617F mutation. Lemierre’s syndrome JAK2V617F Essential thrombocythemia Myeloproliferative neoplasm Septic emboli Figures Figure 1 Figure 2 Figure 3 Introduction Lemierre’s syndrome (LS) is a rare and potentially life-threatening systemic infection, characterized by thrombophlebitis of the internal jugular vein and abscess formation in distant organs, such as the lungs, often following tonsillitis, pharyngitis, or oral infections [ 1 , 2 , 3 ]. The syndrome is named after Dr. André Lemierre, who first reported it in 1936. At the time of Lemierre’s report, penicillin-based antibiotics were unavailable, and the primary treatment involved vein ligation, resulting in a high mortality rate, with 18 of the 20 reported cases being fatal. With the advent and development of antibiotics, the incidence of LS has dramatically decreased, to the point where it is now often referred to as a "forgotten disease [ 3 ]." However, in recent years, there has been a resurgence in LS cases, likely due to a decline in the use of antibiotics [ 2 ]. Although LS is most associated with pharyngeal infections, there have also been several, albeit less frequent, reports linking it to odontogenic infections [ 4 ]. Central nervous system complications have also been reported, including meningitis, brain abscesses, subdural or epidural empyema, septic emboli, and strokes [ 5 ]. Cerebral venous thrombosis has also been observed [ 6 , 7 ]. Essential thrombocythemia (ET) is a myeloproliferative disorder characterized by the overproduction of platelets [ 8 ]. The clinical course of ET is typically chronic, with rare progression to acute myeloid leukemia [ 9 ] (with a 15-year cumulative risk of approximately 3% on average) or myelofibrosis [ 10 ] (a 15-year cumulative risk of around 10% on average, with a higher risk in type 1 CALR -mutant ET compared to JAK2 -mutant ET). There is an elevated risk of thrombotic events in patients with thrombocytosis associated with ET [ 8 , 10 ], particularly in those with the JAK2V617F mutation, which significantly increases this risk [ 8 ]. Moreover, thrombosis in ET is typically associated with arterial events, such as platelet thrombi; however, the risk of venous thrombosis, including deep vein thrombosis (DVT), is also elevated [ 11 , 12 ]. The 15-year cumulative risk of thrombosis varies between 10% and 25%, depending on the molecular subtype, further highlighting the vascular complications associated with this condition [ 9 ]. Approximately 50–60% of patients with ET harbor a mutation in the JAK2 gene, most commonly the JAK2V617F mutation [ 11 ]. This gain-of-function mutation arises from a G-to-T somatic mutation at nucleotide 1849 in exon 14, leading to a substitution of valine to phenylalanine at codon 617 [ 8 ]. Consequently, constitutive activation of the JAK-STAT pathway drives excessive platelet production. To mitigate these risks, cytoreductive therapies such as hydroxyurea or anagrelide are commonly utilized, alongside antithrombotic treatment with aspirin [ 12 ]. Cerebral venous thrombosis (CVT) is a rare condition, with an annual incidence of 1–2 cases per million [ 13 , 14 ]. It is observed more commonly in women, with a female-to-male ratio of 3:1 [ 15 , 16 ]. Risk factors for CVT include infections and prothrombotic conditions, either genetic or acquired, both of which were present in this patient [ 14 ]. Case presentation A 66-year-old male with a history of hypertension and internal hemorrhoids was noted to have thrombocytosis during a routine health examination. His platelet count was markedly elevated to 985 × 10⁹/L. Allele-specific quantitative PCR identified a JAK2 V617F mutation with an allele burden of 21.8%. Further cytogenetic testing for myeloproliferative disorders did not reveal any additional genetic alterations in CALR, MPL, BCR-ABL1, or other JAK2 mutations beyond the JAK2V617F mutation. Following the diagnosis, treatment with aspirin and hydroxyurea were initiated. Three months after the diagnosis of ET, the patient suffered a left temporal lobe hypertensive hemorrhage. At the time of admission, his platelet count remained elevated at 890 × 10⁹/L, suggesting secondary von Willebrand disease related to consumptive depletion of von Willebrand factor associated with thrombocytosis. Subsequently, aspirin and hydroxyurea were resumed at carefully adjusted intervals. Three years after the diagnosis of ET, the patient developed pain in the right mandibular region. The patient visited a dental clinic, where he was diagnosed with apical periodontitis of the maxillary right second molar (tooth #7), and treatment was scheduled. However, within a week after the dental visit, the patient's pain progressively worsened. The pain intensified significantly, escalating to severe, pulsatile pain radiating from the right temporal region to the occipital area. This led to his admission to our hospital. The patient described the headache as severe and excruciating, with pain so intense that he was continuously shouting in distress. The patient had a notable medical history of ET, a left temporal lobe hypertensive hemorrhage, and hypertension. His current medications included aspirin, hydroxyurea, amlodipine, and lansoprazole. He lived alone, was unemployed, and consumed alcohol frequently, although he had no history of smoking or substance abuse. Additionally, there was no recent contact with animals or birds, no international travel, and no consumption of raw or undercooked meat. His mother had died of sarcoidosis, while his father was in good health. A lumbar puncture revealed clear cerebrospinal fluid. Cerebrospinal fluid analysis showed a white blood cell count of 8.0 × 10⁶/L, with 29.2% polymorphonuclear cells and 70.8% mononuclear cells, as well as a total protein concentration of 0.67 g/L and a glucose level of 0.53 g/L. These findings were not indicative of central nervous system infections, such as meningitis or encephalitis, nor did they suggest intracerebral hemorrhage. A whole-brain CT scan showed no significant abnormalities, including hemorrhage, abscess, or tumor. The patient was diagnosed with occipital neuralgia, for which loxoprofen was prescribed. He was subsequently discharged with residual pain, with follow-up planned on an outpatient basis. Later that night, the patient, unable to endure the severe pain, called an ambulance and was transported to our hospital for further evaluation. On admission, his vital signs were as follows: body temperature of 37.8ºC, pulse rate of 81 beats per minute, blood pressure of 132/76 mmHg, and oxygen saturation of 98%. Mild neck stiffness was noted; however, Kernig's sign was negative. Pupillary reflexes were normal, with both pupils equal in size at 3 mm and showing a prompt response to light. No motor deficits were observed in the extremities. Respiratory and cardiac auscultation revealed normal breath sounds and heart sounds, with no murmurs or adventitious sounds. The abdomen was flat and soft, with normal bowel sounds and no tenderness on palpation. The liver and spleen were non-palpable, and no superficial lymphadenopathy was detected. Skin examination revealed no rashes, pallor, or diaphoresis. Capillary refill was less than 2 seconds, and no peripheral edema was noted. The patient was alert and oriented to time, place, and person. An electrocardiogram showed sinus tachycardia with a heart rate of 90 beats per minute. Laboratory findings revealed a white blood cell count of 20.3 × 10⁹/L, hemoglobin of 13.3 g/dL, platelet count of 675 × 10⁹/L, elevated C-reactive protein at 180 mg/L, procalcitonin at 0.72 ng/mL, and D-dimer at 21.0 µg/dL. The results of additional blood tests are provided in Table 1 . Table. 1 Results of Blood Tests: The blood test results indicated a heightened inflammatory state and increased fibrinolytic activity. Due to the patient's severe headache, fever, and elevated inflammatory markers suggesting an urgent systemic infectious process, as well as increased D-dimer levels raising suspicion of thrombosis, a contrast-enhanced CT scan of the entire body was performed. The scan revealed subpleural nodular lesions with central necrosis, likely secondary to septic infarcts, along with clearly identifiable feeding vessels that suggested stasis. (Fig. 1 a-d). Additionally, maxillary osteolysis and soft tissue swelling around the apex of the maxillary right second molar (tooth #7) were observed. (Fig. 1 e, f). No splenomegaly was observed. These findings were highly suggestive of septic embolism, prompting emergency hospitalization. Consequently, the patient underwent tooth extraction and drainage, accompanied by pain management with morphine and a nerve root block due to suspected occipital neuralgia. Despite these interventions, the patient's pain showed only minimal improvement. Cultures from the drained pus identified the presence of alpha-hemolytic streptococcus. Given the patient's severe oral infection, intense headaches, and multiple pulmonary septic emboli, LS was highly suspected, prompting gadolinium-enhanced magnetic resonance imaging (MRI). The MRI revealed a 7 mm defect extending from the right sigmoid sinus into the right internal jugular vein (IJV), suggesting thrombosis (Fig. 2 ). No contrast enhancement was observed in the subdural or subarachnoid spaces to suggest meningitis. Based on the above findings, the patient was diagnosed with LS, which originated from a pulp infection of the right maxillary second molar, leading to suppurative thrombophlebitis. Two blood cultures were obtained, both of which identified alpha-hemolytic streptococcus. Echocardiography revealed no valvular abnormalities or vegetations suggestive of infective endocarditis. Urinalysis results were within normal limits, with no evidence of pyelonephritis. Empiric antimicrobial therapy with meropenem and vancomycin was initiated, based on previous reports indicating that LS is frequently associated with sepsis caused by multiple species of oral anaerobic bacteria. Following the patient's clinical course and culture results, appropriate de-escalation of antibiotics was performed according to infectious disease guidelines [ 1 ]. As shown in Fig. 3 , the patient's fever, headache, and inflammatory markers gradually improved. To prevent thrombosis-related cerebral venous occlusion, oral anticoagulation therapy with edoxaban was initiated. Ten days after starting anticoagulation therapy, contrast-enhanced MRI confirmed complete resolution of the thrombosis in the right sigmoid sinus and right IJV. Weekly blood cultures remained negative following the initiation of antimicrobial therapy. The patient was discharged 13 days after admission and transitioned to oral antibiotics at that time, with no recurrence of LS observed. Discussion This report documents the first case of LS in a patient with JAK2V617F-positive MPN. This case provides valuable insights into the association between inflammatory conditions and the heightened thrombotic risk observed in JAK2V617F-positive MPN, emphasizing its significance in understanding the interplay between these two pathophysiological processes. Bacterial and viral infections promote platelet aggregation by indirectly inducing endothelial cell damage and inflammation [ 17 ] and by directly stimulating the expression of tissue factor on monocytes and endothelial cells [ 18 ]. This process leads to the activation of the intrinsic coagulation pathway [ 19 ] and inhibits normal anticoagulant mechanisms [ 20 ]. Furthermore, antiphospholipid antibodies produced in response to bacterial and viral infections may trigger thrombotic syndromes that are clinically indistinguishable from classic antiphospholipid syndrome [ 21 ]. Additionally, inflammation induced by infections increases the expression of procoagulant cytokines, including interleukin-1, IL-6, and tumor necrosis factor-alpha, which further enhances platelet activation [ 22 ]. These findings across various studies provide insight into the prothrombotic and proinflammatory conditions. In murine models, it was demonstrated that the JAK2V617F mutation increases the adhesion of platelets and neutrophils in cerebral veins, exacerbating endothelial inflammation and leading to a higher thrombus burden. This, in turn, resulted in a greater incidence of intracerebral hemorrhage and increased mortality [ 23 ]. In the human cohort study, JAK2V617F-positive CVT patients exhibited a higher thrombus burden and elevated systemic immune-inflammatory index than JAK2V617F-negative CVT patients [ 23 ]. Additionally, studies in murine models of JAK2V617F-positive MPN have demonstrated that activation of leukocyte β1 and β2 integrins leads to an increased risk of venous thrombosis [ 24 ]. JAK2V617F-positive MPN are thought to promote DVT, including CVT, not only through prothrombotic conditions but also by inducing proinflammatory responses via alterations in various pathways. The coexistence of JAK2V617F-positive MPN and thrombosis secondary to localized infection may be more common than previously recognized, considering the proinflammatory and prothrombotic properties associated with the JAK2V617F mutation. Conclusion This case report specifically addresses the relationship between the JAK2V617F mutation and thrombosis arising from localized infection, suggesting that inflammatory conditions, such as infection, may act as a ‘hiding in plain sight’ factor promoting the formation of DVT in JAK2V617F-positive MPN. We hope that widespread readership of this report among clinicians will lead to an accumulation of evidence on the relationship between thrombosis and inflammation in JAK2V617F-positive MPN patients, ultimately contributing to improved management strategies for thrombosis prevention in these individuals. Abbreviations LS Lemierre’s syndrome ET Essential thrombocythemia MPN Myeloproliferative neoplasm DVT Deep vein thrombosis CVT Cerebral venous thrombosis CNS Central nervous system JAK2V617F A specific gain-of-function mutation in the JAK2 gene PCR Polymerase chain reaction CT Computed tomography MRI Magnetic resonance imaging IJV Internal jugular vein Declarations Acknowledgments We are thankful to the patient for the support given in providing data. Author contributions TIT, SN, KT, NT, SS, and MN treated the patient. TIT, SK1 (Shoichiro Kato), TM, SK2 (Shinichi Kobayashi), and FK were involved in therapeutic decision-making. TIT, TS, KT, HO, KS, and AY performed data collection. TIT, SK2, and AY wrote the introduction and case presentation sections of the manuscript. TIT, AY, and FK wrote the discussion section of the manuscript. All authors reviewed the manuscript. Funding No funding was received to assist with the preparation of this manuscript. Data availability No datasets were generated or analyzed during the current study. Ethics approval and consent to participate The study was conducted according to the guidelines of the Declaration of Helsinki. Patient consent for publication Written informed consent was obtained from the patient for publication of the data and images in this case report. Competing interests The authors declare no competing interests. References Gore MR (2020) Lemierre Syndrome: A Meta-analysis. Int Arch Otorhinolaryngol 24(3):e379–e85. http://doi.org/10.1055/s-0039-3402433 Lee WS, Jean SS, Chen FL, Hsieh SM, Hsueh PR (2020) Lemierre's syndrome: A forgotten and re-emerging infection. 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Cite Share Download PDF Status: Published Journal Publication published 20 Mar, 2025 Read the published version in Annals of Hematology → Version 1 posted Editorial decision: Revision requested 10 Jan, 2025 Reviewers agreed at journal 18 Dec, 2024 Reviews received at journal 25 Nov, 2024 Reviewers agreed at journal 25 Nov, 2024 Reviewers invited by journal 25 Nov, 2024 Editor assigned by journal 18 Nov, 2024 Submission checks completed at journal 18 Nov, 2024 First submitted to journal 08 Nov, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5416591","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":382505518,"identity":"c0c92c09-9a6a-4a71-952e-bd944499906a","order_by":0,"name":"Takuya 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College","correspondingAuthor":false,"prefix":"","firstName":"Fumihiko","middleName":"","lastName":"Kimura","suffix":""}],"badges":[],"createdAt":"2024-11-08 12:38:16","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-5416591/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-5416591/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1007/s00277-025-06234-z","type":"published","date":"2025-03-20T15:58:11+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":71808892,"identity":"f36f308e-4578-4380-9deb-57594b0f44c3","added_by":"auto","created_at":"2024-12-18 18:03:06","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":16978652,"visible":true,"origin":"","legend":"\u003cp\u003eFindings on CT Imaging: Chest CT revealed multiple nodular lesions predominantly in the bilateral peripheral regions, with contrast enhancement showing central necrosis. Multiple subpleural nodular opacities observed under lung window settings (a, b). Contrast-enhanced CT revealed nodules with internal necrosis, characteristic of infectious embolic lesions (c, d). Osteolysis of the maxillary bone surrounding the apex of the maxillary right second molar (e), with soft tissue swelling exhibiting contrast enhancement in the surrounding area (f).\u003c/p\u003e","description":"","filename":"Figure1.png","url":"https://assets-eu.researchsquare.com/files/rs-5416591/v1/6597a3e1e4372e7ca72441f6.png"},{"id":71808891,"identity":"ef38304a-9f5a-46d2-a39d-2ad7566f13be","added_by":"auto","created_at":"2024-12-18 18:03:06","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":2558081,"visible":true,"origin":"","legend":"\u003cp\u003eFindings on Contrast-Enhanced MRI: Contrast-enhanced brain MRI revealed a defect suspicious for thrombosis extending from the right sigmoid sinus to the right internal jugular vein.\u003c/p\u003e","description":"","filename":"Figure2.png","url":"https://assets-eu.researchsquare.com/files/rs-5416591/v1/bb43562798f119f945d366b4.png"},{"id":71808890,"identity":"57322d61-93b2-4575-9c71-b0142346d6a3","added_by":"auto","created_at":"2024-12-18 18:03:06","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":445216,"visible":true,"origin":"","legend":"\u003cp\u003eClinical Course and Changes in Symptoms and Inflammatory Markers: Following tooth extraction, wound drainage, and the administration of antibiotics, the patient demonstrated gradual improvement in fever, headache, and inflammatory markers. Pain was assessed using the Numerical Rating Scale\u003c/p\u003e","description":"","filename":"figure3.png","url":"https://assets-eu.researchsquare.com/files/rs-5416591/v1/f4120c941ca5fedcc1408f87.png"},{"id":79120707,"identity":"787f3965-b289-4214-bd12-597b0bf44a9a","added_by":"auto","created_at":"2025-03-24 16:11:10","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":17843854,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5416591/v1/0229660f-748a-486e-834a-09b393dca1d0.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Proinflammatory and Prothrombotic Conditions in JAK2V617F-Positive MPN: A Case of Lemierre’s Syndrome in Essential Thrombocythemia","fulltext":[{"header":"Introduction","content":"\u003cp\u003eLemierre\u0026rsquo;s syndrome (LS) is a rare and potentially life-threatening systemic infection, characterized by thrombophlebitis of the internal jugular vein and abscess formation in distant organs, such as the lungs, often following tonsillitis, pharyngitis, or oral infections [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e, \u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e, \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]. The syndrome is named after Dr. Andr\u0026eacute; Lemierre, who first reported it in 1936. At the time of Lemierre\u0026rsquo;s report, penicillin-based antibiotics were unavailable, and the primary treatment involved vein ligation, resulting in a high mortality rate, with 18 of the 20 reported cases being fatal. With the advent and development of antibiotics, the incidence of LS has dramatically decreased, to the point where it is now often referred to as a \"forgotten disease [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e].\" However, in recent years, there has been a resurgence in LS cases, likely due to a decline in the use of antibiotics [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. Although LS is most associated with pharyngeal infections, there have also been several, albeit less frequent, reports linking it to odontogenic infections [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. Central nervous system complications have also been reported, including meningitis, brain abscesses, subdural or epidural empyema, septic emboli, and strokes [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. Cerebral venous thrombosis has also been observed [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e, \u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eEssential thrombocythemia (ET) is a myeloproliferative disorder characterized by the overproduction of platelets [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. The clinical course of ET is typically chronic, with rare progression to acute myeloid leukemia [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e] (with a 15-year cumulative risk of approximately 3% on average) or myelofibrosis [\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e] (a 15-year cumulative risk of around 10% on average, with a higher risk in type 1 \u003cem\u003eCALR\u003c/em\u003e-mutant ET compared to \u003cem\u003eJAK2\u003c/em\u003e-mutant ET). There is an elevated risk of thrombotic events in patients with thrombocytosis associated with ET [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e, \u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e], particularly in those with the JAK2V617F mutation, which significantly increases this risk [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. Moreover, thrombosis in ET is typically associated with arterial events, such as platelet thrombi; however, the risk of venous thrombosis, including deep vein thrombosis (DVT), is also elevated [\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e, \u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e]. The 15-year cumulative risk of thrombosis varies between 10% and 25%, depending on the molecular subtype, further highlighting the vascular complications associated with this condition [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e]. Approximately 50\u0026ndash;60% of patients with ET harbor a mutation in the \u003cem\u003eJAK2\u003c/em\u003e gene, most commonly the JAK2V617F mutation [\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. This gain-of-function mutation arises from a G-to-T somatic mutation at nucleotide 1849 in exon 14, leading to a substitution of valine to phenylalanine at codon 617 [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. Consequently, constitutive activation of the JAK-STAT pathway drives excessive platelet production. To mitigate these risks, cytoreductive therapies such as hydroxyurea or anagrelide are commonly utilized, alongside antithrombotic treatment with aspirin [\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eCerebral venous thrombosis (CVT) is a rare condition, with an annual incidence of 1\u0026ndash;2 cases per million [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e, \u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e]. It is observed more commonly in women, with a female-to-male ratio of 3:1 [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e, \u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e]. Risk factors for CVT include infections and prothrombotic conditions, either genetic or acquired, both of which were present in this patient [\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e].\u003c/p\u003e"},{"header":"Case presentation","content":"\u003cp\u003eA 66-year-old male with a history of hypertension and internal hemorrhoids was noted to have thrombocytosis during a routine health examination. His platelet count was markedly elevated to 985 \u0026times; 10⁹/L. Allele-specific quantitative PCR identified a JAK2 V617F mutation with an allele burden of 21.8%. Further cytogenetic testing for myeloproliferative disorders did not reveal any additional genetic alterations in CALR, MPL, BCR-ABL1, or other JAK2 mutations beyond the JAK2V617F mutation.\u003c/p\u003e\n\u003cp\u003eFollowing the diagnosis, treatment with aspirin and hydroxyurea were initiated. Three months after the diagnosis of ET, the patient suffered a left temporal lobe hypertensive hemorrhage. At the time of admission, his platelet count remained elevated at 890 \u0026times; 10⁹/L, suggesting secondary von Willebrand disease related to consumptive depletion of von Willebrand factor associated with thrombocytosis. Subsequently, aspirin and hydroxyurea were resumed at carefully adjusted intervals.\u003c/p\u003e\n\u003cp\u003eThree years after the diagnosis of ET, the patient developed pain in the right mandibular region. The patient visited a dental clinic, where he was diagnosed with apical periodontitis of the maxillary right second molar (tooth #7), and treatment was scheduled. However, within a week after the dental visit, the patient\u0026apos;s pain progressively worsened. The pain intensified significantly, escalating to severe, pulsatile pain radiating from the right temporal region to the occipital area. This led to his admission to our hospital. The patient described the headache as severe and excruciating, with pain so intense that he was continuously shouting in distress.\u003c/p\u003e\n\u003cp\u003eThe patient had a notable medical history of ET, a left temporal lobe hypertensive hemorrhage, and hypertension. His current medications included aspirin, hydroxyurea, amlodipine, and lansoprazole. He lived alone, was unemployed, and consumed alcohol frequently, although he had no history of smoking or substance abuse. Additionally, there was no recent contact with animals or birds, no international travel, and no consumption of raw or undercooked meat. His mother had died of sarcoidosis, while his father was in good health.\u003c/p\u003e\n\u003cp\u003eA lumbar puncture revealed clear cerebrospinal fluid. Cerebrospinal fluid analysis showed a white blood cell count of 8.0 \u0026times; 10⁶/L, with 29.2% polymorphonuclear cells and 70.8% mononuclear cells, as well as a total protein concentration of 0.67 g/L and a glucose level of 0.53 g/L. These findings were not indicative of central nervous system infections, such as meningitis or encephalitis, nor did they suggest intracerebral hemorrhage. A whole-brain CT scan showed no significant abnormalities, including hemorrhage, abscess, or tumor. The patient was diagnosed with occipital neuralgia, for which loxoprofen was prescribed. He was subsequently discharged with residual pain, with follow-up planned on an outpatient basis.\u003c/p\u003e\n\u003cp\u003eLater that night, the patient, unable to endure the severe pain, called an ambulance and was transported to our hospital for further evaluation. On admission, his vital signs were as follows: body temperature of 37.8\u0026ordm;C, pulse rate of 81 beats per minute, blood pressure of 132/76 mmHg, and oxygen saturation of 98%. Mild neck stiffness was noted; however, Kernig\u0026apos;s sign was negative. Pupillary reflexes were normal, with both pupils equal in size at 3 mm and showing a prompt response to light. No motor deficits were observed in the extremities. Respiratory and cardiac auscultation revealed normal breath sounds and heart sounds, with no murmurs or adventitious sounds. The abdomen was flat and soft, with normal bowel sounds and no tenderness on palpation. The liver and spleen were non-palpable, and no superficial lymphadenopathy was detected. Skin examination revealed no rashes, pallor, or diaphoresis. Capillary refill was less than 2 seconds, and no peripheral edema was noted. The patient was alert and oriented to time, place, and person.\u003c/p\u003e\n\u003cp\u003eAn electrocardiogram showed sinus tachycardia with a heart rate of 90 beats per minute. Laboratory findings revealed a white blood cell count of 20.3 \u0026times; 10⁹/L, hemoglobin of 13.3 g/dL, platelet count of 675 \u0026times; 10⁹/L, elevated C-reactive protein at 180 mg/L, procalcitonin at 0.72 ng/mL, and D-dimer at 21.0 \u0026micro;g/dL. The results of additional blood tests are provided in Table \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable. 1\u0026nbsp;\u003c/strong\u003eResults of Blood Tests: The blood test results indicated a heightened inflammatory state and increased fibrinolytic activity.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg 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\"\u003e\u003c/strong\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003eDue to the patient\u0026apos;s severe headache, fever, and elevated inflammatory markers suggesting an urgent systemic infectious process, as well as increased D-dimer levels raising suspicion of thrombosis, a contrast-enhanced CT scan of the entire body was performed. The scan revealed subpleural nodular lesions with central necrosis, likely secondary to septic infarcts, along with clearly identifiable feeding vessels that suggested stasis. (Fig. \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003ea-d). Additionally, maxillary osteolysis and soft tissue swelling around the apex of the maxillary right second molar (tooth #7) were observed. (Fig. \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003ee, f). No splenomegaly was observed. These findings were highly suggestive of septic embolism, prompting emergency hospitalization.\u003c/p\u003e\n\u003cp\u003eConsequently, the patient underwent tooth extraction and drainage, accompanied by pain management with morphine and a nerve root block due to suspected occipital neuralgia. Despite these interventions, the patient\u0026apos;s pain showed only minimal improvement. Cultures from the drained pus identified the presence of alpha-hemolytic streptococcus.\u003c/p\u003e\n\u003cp\u003eGiven the patient\u0026apos;s severe oral infection, intense headaches, and multiple pulmonary septic emboli, LS was highly suspected, prompting gadolinium-enhanced magnetic resonance imaging (MRI). The MRI revealed a 7 mm defect extending from the right sigmoid sinus into the right internal jugular vein (IJV), suggesting thrombosis (Fig. \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e). No contrast enhancement was observed in the subdural or subarachnoid spaces to suggest meningitis. Based on the above findings, the patient was diagnosed with LS, which originated from a pulp infection of the right maxillary second molar, leading to suppurative thrombophlebitis. Two blood cultures were obtained, both of which identified alpha-hemolytic streptococcus. Echocardiography revealed no valvular abnormalities or vegetations suggestive of infective endocarditis. Urinalysis results were within normal limits, with no evidence of pyelonephritis.\u003c/p\u003e\n\u003cp\u003eEmpiric antimicrobial therapy with meropenem and vancomycin was initiated, based on previous reports indicating that LS is frequently associated with sepsis caused by multiple species of oral anaerobic bacteria. Following the patient\u0026apos;s clinical course and culture results, appropriate de-escalation of antibiotics was performed according to infectious disease guidelines [\u003cspan class=\"CitationRef\"\u003e1\u003c/span\u003e].\u003c/p\u003e\n\u003cp\u003eAs shown in Fig. \u003cspan class=\"InternalRef\"\u003e3\u003c/span\u003e, the patient\u0026apos;s fever, headache, and inflammatory markers gradually improved. To prevent thrombosis-related cerebral venous occlusion, oral anticoagulation therapy with edoxaban was initiated. Ten days after starting anticoagulation therapy, contrast-enhanced MRI confirmed complete resolution of the thrombosis in the right sigmoid sinus and right IJV. Weekly blood cultures remained negative following the initiation of antimicrobial therapy. The patient was discharged 13 days after admission and transitioned to oral antibiotics at that time, with no recurrence of LS observed.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThis report documents the first case of LS in a patient with JAK2V617F-positive MPN. This case provides valuable insights into the association between inflammatory conditions and the heightened thrombotic risk observed in JAK2V617F-positive MPN, emphasizing its significance in understanding the interplay between these two pathophysiological processes.\u003c/p\u003e \u003cp\u003eBacterial and viral infections promote platelet aggregation by indirectly inducing endothelial cell damage and inflammation [\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e] and by directly stimulating the expression of tissue factor on monocytes and endothelial cells [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e]. This process leads to the activation of the intrinsic coagulation pathway [\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e] and inhibits normal anticoagulant mechanisms [\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e]. Furthermore, antiphospholipid antibodies produced in response to bacterial and viral infections may trigger thrombotic syndromes that are clinically indistinguishable from classic antiphospholipid syndrome [\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e]. Additionally, inflammation induced by infections increases the expression of procoagulant cytokines, including interleukin-1, IL-6, and tumor necrosis factor-alpha, which further enhances platelet activation [\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. These findings across various studies provide insight into the prothrombotic and proinflammatory conditions.\u003c/p\u003e \u003cp\u003eIn murine models, it was demonstrated that the JAK2V617F mutation increases the adhesion of platelets and neutrophils in cerebral veins, exacerbating endothelial inflammation and leading to a higher thrombus burden. This, in turn, resulted in a greater incidence of intracerebral hemorrhage and increased mortality [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e]. In the human cohort study, JAK2V617F-positive CVT patients exhibited a higher thrombus burden and elevated systemic immune-inflammatory index than JAK2V617F-negative CVT patients [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e]. Additionally, studies in murine models of JAK2V617F-positive MPN have demonstrated that activation of leukocyte β1 and β2 integrins leads to an increased risk of venous thrombosis [\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eJAK2V617F-positive MPN are thought to promote DVT, including CVT, not only through prothrombotic conditions but also by inducing proinflammatory responses via alterations in various pathways. The coexistence of JAK2V617F-positive MPN and thrombosis secondary to localized infection may be more common than previously recognized, considering the proinflammatory and prothrombotic properties associated with the JAK2V617F mutation.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThis case report specifically addresses the relationship between the JAK2V617F mutation and thrombosis arising from localized infection, suggesting that inflammatory conditions, such as infection, may act as a \u0026lsquo;hiding in plain sight\u0026rsquo; factor promoting the formation of DVT in JAK2V617F-positive MPN. We hope that widespread readership of this report among clinicians will lead to an accumulation of evidence on the relationship between thrombosis and inflammation in JAK2V617F-positive MPN patients, ultimately contributing to improved management strategies for thrombosis prevention in these individuals.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cdiv class=\"DefinitionList\"\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eLS\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eLemierre\u0026rsquo;s syndrome\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eET\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eEssential thrombocythemia\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eMPN\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eMyeloproliferative neoplasm\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eDVT\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eDeep vein thrombosis\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eCVT\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eCerebral venous thrombosis\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eCNS\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eCentral nervous system\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eJAK2V617F\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eA specific gain-of-function mutation in the JAK2 gene\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003ePCR\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003ePolymerase chain reaction\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eCT\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eComputed tomography\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eMRI\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eMagnetic resonance imaging\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eIJV\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eInternal jugular vein\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003c/div\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgments\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe are thankful to the patient for the support given in providing data.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTIT, SN, KT, NT, SS, and MN treated the patient. TIT, SK1 (Shoichiro Kato), TM, SK2 (Shinichi Kobayashi), and FK were involved in therapeutic decision-making. TIT, TS, KT, HO, KS, and AY performed data collection. TIT, SK2, and AY wrote the introduction and case presentation sections of the manuscript. TIT, AY, and FK wrote the discussion section of the manuscript. All authors reviewed the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNo funding was received to assist with the preparation of this manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData availability\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNo datasets were generated or analyzed during the current study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study was conducted according to the guidelines of the Declaration of Helsinki.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePatient consent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWritten informed consent was obtained from the patient for publication of the data and images in this case report.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare no competing interests.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eGore MR (2020) Lemierre Syndrome: A Meta-analysis. 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J Clin Invest 128(10):4359\u0026ndash;4371. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttp://doi.org/10.1172/JCI90312\u003c/span\u003e\u003cspan address=\"10.1172/JCI90312\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"annals-of-hematology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"aohe","sideBox":"Learn more about [Annals of Hematology](http://link.springer.com/journal/277)","snPcode":"277","submissionUrl":"https://submission.nature.com/new-submission/277/3","title":"Annals of Hematology","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"Lemierre’s syndrome, JAK2V617F, Essential thrombocythemia, Myeloproliferative neoplasm, Septic emboli","lastPublishedDoi":"10.21203/rs.3.rs-5416591/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5416591/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eLemierre’s syndrome (LS) represents a rare yet potentially life-threatening systemic infection, characterized by thrombophlebitis of the internal jugular vein and abscess formation in distant organs. It typically follows episodes of tonsillitis or other infections of the oropharyngeal region. Pulmonary complications, including septic pulmonary emboli, are common. Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm (MPN) sometimes associated with the JAK2V617F mutation, which predisposes patients to thrombotic events. A 66-year-old male with JAK2V617F-positive ET presented with severe pulsatile pain radiating from the right temporal region to the occipital area following a recent dental infection. Although pain management was administered, the pain continued to persist. Computed tomography of the chest revealed multiple subpleural nodules, raising suspicion for septic pulmonary emboli. Further investigation with gadolinium-enhanced magnetic resonance imaging identified a thrombus extending from the right sigmoid sinus into the internal jugular vein, consistent with cerebral venous thrombosis. The patient was diagnosed with LS, complicated by septic thrombosis. Blood cultures yielded alpha-hemolytic streptococcus. Empirical antimicrobial therapy combined with anticoagulation was initiated, resulting in a gradual improvement of symptoms, including the resolution of fever and pain. Follow-up imaging confirmed the resolution of both the infection and thrombosis. This is the first reported case of LS in a patient with JAK2V617F-positive ET. The coexistence of LS and JAK2V617F-positive MPN highlights the potential interplay between proinflammatory and prothrombotic conditions associated with the JAK2V617F mutation.\u003c/p\u003e","manuscriptTitle":"Proinflammatory and Prothrombotic Conditions in JAK2V617F-Positive MPN: A Case of Lemierre’s Syndrome in Essential Thrombocythemia","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-12-18 18:03:01","doi":"10.21203/rs.3.rs-5416591/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2025-01-10T14:10:18+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"219069592425974852353326225616898099582","date":"2024-12-18T12:49:36+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-11-25T18:19:09+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"75300905217078082707018434608332359519","date":"2024-11-25T17:20:43+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2024-11-25T15:59:14+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2024-11-18T14:24:27+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2024-11-18T14:23:24+00:00","index":"","fulltext":""},{"type":"submitted","content":"Annals of Hematology","date":"2024-11-08T12:27:27+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"annals-of-hematology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"aohe","sideBox":"Learn more about [Annals of Hematology](http://link.springer.com/journal/277)","snPcode":"277","submissionUrl":"https://submission.nature.com/new-submission/277/3","title":"Annals of Hematology","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"00fcfb2e-2a1a-43eb-a6fc-3180ec0509af","owner":[],"postedDate":"December 18th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2025-03-24T16:07:00+00:00","versionOfRecord":{"articleIdentity":"rs-5416591","link":"https://doi.org/10.1007/s00277-025-06234-z","journal":{"identity":"annals-of-hematology","isVorOnly":false,"title":"Annals of Hematology"},"publishedOn":"2025-03-20 15:58:11","publishedOnDateReadable":"March 20th, 2025"},"versionCreatedAt":"2024-12-18 18:03:01","video":"","vorDoi":"10.1007/s00277-025-06234-z","vorDoiUrl":"https://doi.org/10.1007/s00277-025-06234-z","workflowStages":[]},"version":"v1","identity":"rs-5416591","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5416591","identity":"rs-5416591","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}