Discovery of a novel biomarker in the urine in women with endometriosis
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Researchers identified Cytokeratin-19 as a significantly up-regulated protein in the urine of women with endometriosis compared to those without.
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Abstract
OBJECTIVE: To investigate whether proteins secreted in urine differ between women with and without endometriosis.
DESIGN: Laboratory study using human urine.
SETTING: University-based laboratory.
PATIENT(S): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage.
INTERVENTION(S): Urine collection from women with and without endometriosis.
MAIN OUTCOME MEASURE(S): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis.
RESULT(S): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis.
CONCLUSION(S): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.
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- europepmc
- last seen: 2026-06-11T06:19:48.454388+00:00
- pubmed
- last seen: 2026-05-13T22:16:54.825375+00:00
- unpaywall
- last seen: 2026-05-14T19:30:52.867331+00:00
License: public-domain-us
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Courtesy of the U.S. National Library of Medicine
Courtesy of the U.S. National Library of Medicine