The Effect of Intravenous Estrogens on Ground Substance

Maurice Schiff, Helen Burn
In: Archives of Otolaryngology - Head and Neck Surgery · 1961 · vol. 73(1) , pp. 43–51 · doi:10.1001/archotol.1961.00740020047005 · PMID:13747614 · W2015819283
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher

Abstract

Intravenous estrogens have been used for years by specialists in various fields of medicine to control bleeding. Many theories have been advanced to explain their mechanism of action. Some of these theories are within the realm of probability, while others do not appear to be applicable. Our studies would seem to indicate that intravenous estrogens have a definite effect on the ground substance rather than on the intravascular factors which have been stressed in the past. For some time, Jacobson1-4wrote about "spontaneous hemorrhage." He drew an analogy between the spontaneous physiological hemorrhage of menstruation and spontaneous hemorrhages elsewhere in the body. Smith and Smith5indicated that a substance was released into the blood stream as the estrogen level decreased. This substance was not identified but was supposed to be one of the initiating factors in uterine bleeding and appeared to have a toxic effect which was specific

My notes (saved in your browser only)

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (10)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK