Uni-Fold: An Open-Source Platform for Developing Protein Folding Models beyond AlphaFold

Recent breakthroughs on protein structure prediction, namely AlphaFold, have led to unprecedented new possibilities in related areas. However, the lack of training utilities in its current open-source code hinders the community from further developing or adapting the model. Here we present Uni-Fold as a thoroughly open-source platform for developing protein folding models beyond AlphaFold. We reimplemented AlphaFold and AlphaFold-Multimer in the PyTorch framework, and reproduced their from-scratch training processes with equivalent or better accuracy. Based on various optimizations, Uni-Fold achieves about 2.2 times training acceleration compared with AlphaFold under similar hardware configuration. On a benchmark of recently released multimeric protein structures, Uni-Fold outperforms AlphaFold-Multimer by approximately 2% on the TM-Score. Uni-Fold is currently the only open-source repository that supports both training and inference of multimeric protein models. The source code, model parameters, test data, and web server of Uni-Fold are publicly available 3 .