Free Radical Conservation and Quantitative Research on Radiation Effects

The purpose of this article is to quantitatively study the influence of direct and indirect action on the radiation effect and its production mechanism. As the indirect action of radiation effects is triggered by the radiolysis of free water molecules, the free radical conservation equation for the same radiation effect is deduced by the definition and theoretical analysis of the radiation effects of microbial cells and biologically active macromolecules with different water contents. Through the free radicals conservation equation, these values were quantitatively calculated with different water contents, which were the D37 value of microbial cells or biological macromolecules, the proportion of direct action and indirect action, the influence on the target volume and number of targets, and the influence on radiation effects. These quantitative calculation results from the free radical conservation equation show that as the water content increases from 0, the radiation sensitivity of RNase and DNA molecules continues to increase, the direct actions gradually decrease, and the indirect actions continue to increase. The quantitative calculation value of D37 decreases with the increase of water content, and the quantitative calculation value of RNase target volume increases with the increase of water content. These quantitative calculation results are completely consistent with the theories and research results of radiation chemistry and radiation biology, fully revealing that the free radical conservation equation is in accordance with objective reality and is scientifically effective. It has laid a scientific theoretical foundation for the quantitative research and application of radiation effects in the future.