Design and Optimization of a Mucoadhesive Gel Containing Solid Lipid Nanoparticles for Sublingual and Nasal Delivery of a Low Bioavailable Drug

This research focuses on the development of a nano lipid mucoadhesive gel utilizing a novel mucoadhesive polymer derived from Moringa oleifera, intended for the delivery of poorly absorbed drug. A novel mucoadhesive polymer made from Moringa oleifera is used to formulate the gel that sticks to oral and nasal mucous membranes better and is safe for the body. The hot homogenization method was used to make the solid lipid nanoparticles (SLNs). The SLNs was analyzed for its particle size, zeta potential, entrapment efficacy, SEM and drug release. These SLNs were mixed into a gel matrix made from a Moringa oleifera extract. Ex-vivo mucoadhesion studies and permeation studies of the SLNs gel is done using porcine goat sublingual mucosa and sheep nasal mucosa, in vitro release showed sustained drug release over 6 hours. Thus, this mucoadhesive SLNs gel can serve as a promising candidate for delivering poorly bioavailable drugs via the sublingual as well as nasal route.