The study of E-cadherin and CD44 varient 6 on pathogenesis in human adenomyosis

Jia-li Kang, Chun-xiang Guan, Xiao-hui Huang, Xiaoxia Wang, Wei Xia
In: Chung-Hua Fu Ch'an K'o Tsa Chih · 2006 · vol. 2(6) , pp. 315–317 · doi:10.3877/cma.j.issn.1673-5250.2006.06.104 · W3028934608
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

This study found reduced E-cadherin expression in adenomyosis endometrium compared to normal endometrium, suggesting a link to the disease's pathogenesis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

The paper investigated E-cadherin and CD44 variant 6 (CD44v6) expression in adenomyosis in vivo by immunohistochemistry, comparing 50 cases’ eutopic and ectopic endometrial tissues with 30 samples of normal endometrium, and assessed their correlation using SPSS. It found that E-cadherin expression was significantly lower in both adenomyosis eutopic and ectopic endometrium than in normal endometrium, while CD44v6 expression was significantly higher. Within adenomyosis tissues, E-cadherin and CD44v6 expression were negatively correlated, whereas no correlation was observed in normal endometrium. The paper explicitly frames these findings as supportive of a role for abnormal, potentially coordinated expression of these molecules in adenomyosis pathogenesis. This paper is centrally about adenomyosis — it focuses on E-cadherin and CD44v6 expression and their correlation in eutopic and ectopic endometrium within adenomyosis.

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Abstract

Objective To observe the expression of E-cadherin and CD44 v6 in human adenomyosis.To explore the correlation between the expression of E-cadherin and CD44 v6 in the pathogenesis of adenomyosis. Methods The expression of E-cadherin and CD44v6 in 50 ectopic and eutopic endometrium of adenomyosis was detected by immunohistochemical method in comparison with 30 normal endometrium. Results were analyzed by SPSS13.0 statistical software.Results The expression of E-cadherin in ectopic and eutopic endometrium of adenomyosis is lower than that in normal endometrium(P 0.05). Conclusion The abnormal expression of E-cadherin and CD44 v6 in eutopic endometrium and ectopic endometrium has relationship with the etiology of adenomyosis. Key words: E-cadherin; CD44 varient 6(CD44v6); adenomyosis; immunohistochemistry
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Objective

To observe the expression of E-cadherin and CD44 v6 in human adenomyosis.To explore the correlation between the expression of E-cadherin and CD44 v6 in the pathogenesis of adenomyosis.

Methods

The expression of E-cadherin and CD44v6 in 50 ectopic and eutopic endometrium of adenomyosis was detected by immunohistochemical method in comparison with 30 normal endometrium.

Results

were analyzed by SPSS13.0 statistical software.Results The expression of E-cadherin in ectopic and eutopic endometrium of adenomyosis is lower than that in normal endometrium(P <0.05).The expression of CD44v6 in ectopic and eutopic endometrium of adenomyosis is higher than that in normal endometrium(P<0.05).There was a negative correlation between the expression of E-cadherin and CD44 v6 in eutopic endometrium of adenomyosis and ectopic endometrium of adenomyosis(P0.05).

Conclusion

The abnormal expression of E-cadherin and CD44 v6 in eutopic endometrium and ectopic endometrium has relationship with the etiology of adenomyosis. | 1 乐杰主编.妇产科学.第6版.北京：人民卫生出版社，2005,361. | | | 2 连利娟主编.林巧稚妇科肿瘤学.第3版.北京：人民卫生出版社，2001,733-738. | | | 3 Sillem M，Hahn U, Coddington CC，et al.Ectopic growth of endometrium depends on its structural integrity and proteolytic antivity in the cynomolgus monkey(Macaca fascicularis)model of endometriosis.Fertil Steril, 1998, 66(3)：468-473. | | | 4 郎景和主编.子宫内膜异位症的基础与临床研究.北京：中国协和医科大学出版社，2003,171. | | | 5 Handschuh G，Candidus S，Luber B，et al.Tumor-associated E-cadherin mutations alter celluar morphology, decrease celluar adhesion and increase celluar motility.Oncogene，1999，18(30): 4301-4312. | | | 6 Zohar R，Suzuki N，Suzuki K，et al.Intracelluar osteopontin is an integral companent of the CD44-ERM complex involced in cell migration.Cell.Physiol, 2000 ，184:118-130. | | | 7 郭立霞，谢弘.CD44与肿瘤转移.生命科学，2001，13(2):61-63. | | | 8 Yu Q，Stamenkovic I.Cell surface-Localized matrix metalloproteinase-9 proteolytically active TGF-β and promotes tumor invasion and angiogenesis.Genes Dev，2000，14:163-176. | | [1] | 赵阳, 肖迎聪, 巨艳, 党晓智, 蔡林利, 薛文欣, 李洋, 肖瑶, 郭妤绮, 宋宏萍. 自动乳腺超声联合免疫组化早期预测乳腺癌新辅助化疗病理完全缓解的临床价值[J/OL]. 中华医学超声杂志（电子版）, 2024, 21(04): 361-369. | | [2] | 武壮壮, 张晓娟, 史泽洪, 史瑶, 原韶玲. 超声联合乳腺X线摄影及PR、Her-2预测高级别与中低级别乳腺导管原位癌的价值[J/OL]. 中华医学超声杂志（电子版）, 2023, 20(06): 631-635. | | [3] | 贺媛媛, 李佳, 杨红. 宫颈中肾腺癌1例并文献复习[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(01): 97-104. | | [4] | 韩春颖, 王婷婷, 李艳艳, 朴金霞. 子宫内膜癌患者淋巴管间隙浸润预测因素研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2023, 19(04): 403-409. | | [5] | 刘星辰, 刘娟, 魏宝宝, 刘洁, 刘辉. XIAP与XAF1异常表达与卵巢癌的相关性分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2023, 19(04): 419-427. | | [6] | 夏恩兰. 囊性子宫腺肌病与子宫副腔畸形[J/OL]. 中华妇幼临床医学杂志(电子版), 2022, 18(06): 746-746. | | [7] | 陈怡芳, 黄晓卉. 肝细胞癌中对氧磷酶2的表达及临床意义[J/OL]. 中华普通外科学文献(电子版), 2024, 18(03): 186-191. | | [8] | 刘政宏, 王凤力, 吉亚君, 高佳. 胃癌中ELK3蛋白的表达与临床病理特征和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(02): 155-159. | | [9] | 郭伟林, 李运涛, 尚培中, 李晓武, 李伟. 胰腺癌S100A4和Midkine表达研究[J/OL]. 中华普外科手术学杂志(电子版), 2023, 17(02): 149-152. | | [10] | 王靖, 高建建, 刘平, 陆美荣, 袁永兴, 胡茜, 孙亮亮, 李君亮, 王海琳. 达芬奇机器人辅助单孔腹腔镜在子宫良性疾病的临床应用分析[J/OL]. 中华腔镜外科杂志(电子版), 2023, 16(06): 342-347. | | [11] | 李峻峰, 李军, 孙勤丰, 孙建光, 孔祥兴. 九例结肠髓样癌的临床病理特征分析[J/OL]. 中华结直肠疾病电子杂志, 2023, 12(03): 248-252. | | [12] | 谭瑞义. 小细胞骨肉瘤诊断及治疗研究现状与进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(08): 781-784. | | [13] | 岳瑞雪, 孔令欣, 郝鑫, 杨进强, 韩猛, 崔国忠, 王建军, 张志生, 孔凡庭, 张维, 何文博, 李现桥, 周新平, 徐东宏, 胡崇珠. 乳腺癌HER2蛋白表达水平预测新辅助治疗疗效的真实世界研究[J/OL]. 中华临床医师杂志(电子版), 2023, 17(07): 765-770. | | [14] | 毛高才, 张建波, 袁一方, 毛小波, 戴慧勇, 王哲. 耳后淋巴结内涎腺透明细胞型嗜酸性腺瘤的诊断学特征[J/OL]. 中华诊断学电子杂志, 2023, 11(04): 261-265. | | [15] | 刘迎, 尹嫚, 杨林青, 王云飞. 子宫颈浸润性复层产黏液的癌的诊断学特征并文献复习[J/OL]. 中华诊断学电子杂志, 2023, 11(03): 173-177. | | 阅读次数 | ||||| | 全文 | | |||| | 摘要 | | |||| 版权所有 中华医学会 中华医学电子音像出版社有限责任公司 京ICP备14006079号-1 网络出版服务许可证：(署)网出证(京)字第075号 AI 小 编 AI小编

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