Expression and significance of uPA,uPAR and PAI-1 in endom etriosis
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This study found higher expression of uPA, uPAR, and PAI-1 in ectopic endometriosis tissue compared to eutopic and normal endometrium, suggesting their involvement in endometriosis pathogenesis.
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Abstract
Objective:To study the expression of uPA,uPAR and PAI-1 in the ectopic endometriosis and in the normal endometrium to explore the hypothesis that uPA,uPAR and PAI-1 play a role in the development of endometrosis.Methods:The expression of uPA,uPAR and PAI-1 in the ectopic endometrium was detected by immunohistochemistry streptavidin-biotin peroxidase method.Results:The expression levels of uPA,uPAR and PAI-1in the ectopic endometrium were higher than those in the eutopic endometrium with endometriosis and the normal endometrium(P0.05,P0.01) There was a significant difference in the expression o f uPA, uPAR and PAI-1 between ectopic and the eutopic endometrium(P0.05).Conclusion:The change of uPA,uPAR and PAI-1 expression in ectopic and eutopic endometrium may be related to the pathogenesis endometriosis.
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- last seen: 2026-06-10T17:14:06.276822+00:00
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