Prevalence and correlates of subclinical hypothyroidism in young first-episode drug-naïve major depression patients with high BMI

Prevalence and correlates of subclinical hypothyroidism in young first-episode drug-naïve major depression patients with high BMI | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 24 March 2025 V1 Latest version Share on Prevalence and correlates of subclinical hypothyroidism in young first-episode drug-naïve major depression patients with high BMI Authors : Chengyang Liu , Xiaojia Ma , Wenbo Qi , Qitao Xu , Xinyue Wang , Yingying Huang , Ping Sun 0000-0003-1565-2872 , and Xiangyang Zhang 0000-0002-3135-2063 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174279077.73077416/v1 203 views 125 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Both subclinical hypothyroidism (SCH) and overweight or obesity are prevalent in major depressive disorder (MDD), with inconsistent results due to differences in inclusion criteria in previous studies. Few previous studies have compared the prevalence and influencing factors of SCH in MDD patients accompanied by overweight or obesity between those who are not. The aim of our study was to examine the prevalence of SCH and associated risk factors among young Chinese first-episode drug-naïve (FEND) MDD patients with overweight or obesity and exclude the impact of age and medication. This study recruited a total of 1289 young FEDN MDD outpatients and their demographic data, clinical information, thyroid function and biochemical parameters were collected. They were also assessed on the Hamilton Depression Inventory (HAMD), Hamilton Anxiety Inventory (HAMA), and Positive and Negative Symptom Scales (PANSS). The incidence of SCH in young FEDN MDD patients with overweight or obesity was 65.78%, which was 1.59 times higher than that in patients without high BMI (28.6%). Patients with SCH had longer duration of illness, higher HAMA, HAMD, and PANSS positive symptom scores, stronger suicide attempts, higher blood pressure (BP), higher fasting blood glucose, total cholesterol (TC) levels and low-density lipoprotein (LDL) levels, and lower high-density lipoprotein (HDL) levels than those without SCH. Additionally, logistic regression showed that the HAMD score, fasting blood glucose, TC levels, HDL-C levels, systolic and diastolic BP were significantly associated with SCH. Furthermore, the combination of TC levels and systolic BP could differentiate patients with SCH from those without SCH. Our results suggested a high incidence of SCH in young MDD patients with high BMI. The severity of depression and several metabolic parameters contribute to the incidence of SCH in young MDD patients with high BMI. Supplementary Material File (liu manuscript.docx) Download 180.95 KB File (supplementary table.docx) Download 21.02 KB Information & Authors Information Version history V1 Version 1 24 March 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords body mass index (bmi) first-episode drug-naïve major depressive disorder metabolic biomarkers subclinical hypothyroidism Authors Affiliations Chengyang Liu Zibo Mental Health Center View all articles by this author Xiaojia Ma Qingdao Mental Health Centre View all articles by this author Wenbo Qi Qingdao Mental Health Centre View all articles by this author Qitao Xu Zibo Mental Health Center View all articles by this author Xinyue Wang Jining Medical University Clinical Medical College View all articles by this author Yingying Huang Nanjing Brain Hospital View all articles by this author Ping Sun 0000-0003-1565-2872 Qingdao Mental Health Centre View all articles by this author Xiangyang Zhang 0000-0002-3135-2063 [email protected] Chinese Academy of Sciences Key Laboratory of Mental Health View all articles by this author Metrics & Citations Metrics Article Usage 203 views 125 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Chengyang Liu, Xiaojia Ma, Wenbo Qi, et al. Prevalence and correlates of subclinical hypothyroidism in young first-episode drug-naïve major depression patients with high BMI. Authorea . 24 March 2025. DOI: https://doi.org/10.22541/au.174279077.73077416/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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