Comparison of the application value of different dose of mifepristone in adenomyosis

Objective To observe and compare the clinical application value of different dose of mifepristone in adenomyosis. Methods 62 patients with adenomyosis in our hospital from February 2012 to October 2013 were selected as the study objects,and they were divided into the group A(6.25 mg/d,n=31) and the group B(12.50 mg/d,n=31) according to the application dose of mifepristone,then the uterine size,dysmenorrhea degree,serum CA125 level and positive rate of CA125 before and after treatment and adverse reaction rate of the two groups were respectively analyzed and compared. Results There was no statistical difference of uterine size,dysmenorrhea degree and serum CA125 level and positive rate of CA125 after 1 month,3 and 6 months treatment in the two groups(all P0.05),and there was a statistical difference of above-mentioned indicators after treatment in the two groups compared with before treatment(all P0.05).The incidence rate of adverse reaction in the group A was obviously lower than that in the control group(P0.05).Conclusion The clinical application value of 6.25 mg/d mifepristone in the treatment of adenomyosis is higher,and it has good treatment effect and the higher safety.