Distribution of Nerve Fibers in Abdominal Wall Endometriosis and Their Clinical Significance

Zhang C, Dai Y, Zhang J, Li X, Jia S, Shi J, Leng J
2024 · W7009276223
article OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex
⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

This retrospective case–control study examined 30 patients with abdominal wall endometriosis and 17 laparotomy controls without endometriosis to assess whether nerve fiber innervation patterns are associated with pain. Using immunostaining markers (S-100, NSE, PGP9.5, NF, and substance P), the authors found higher densities of S-100, NSE, and PGP9.5 immunoreactive nerve fibers and a greater proportion of substance P–positive fibers in AWE lesions versus normal abdominal wall scars, while neurofilament-positive fibers did not differ. The study also reported no statistically significant correlation between the measured nerve fiber densities/proportions (including substance P) and pain scores. This paper is centrally about endometriosis — it specifically characterizes nerve fiber distribution in abdominal wall endometriosis and evaluates associations with pain.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Chenyu Zhang,1 Yi Dai,1 Junji Zhang,1 Xiaoyan Li,1 Shuangzheng Jia,2 Jinghua Shi,1,* Jinhua Leng1,* 1Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, People’s Republic of China; 2Department of Gynecologic Oncology, National Cancer Center / National Clinical Research Center for Cancer / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinghua Shi; Jinhua Leng, Tel +86 151-0101-6294 ; +86 137-0129-8616, Email [email protected]; [email protected]: This study aimed to explore the distribution of nerve fibers in abdominal wall endometriosis (AWE) and discern their association with pain.Methods: A retrospective case–control study was conducted. The cases comprised 30 patients diagnosed with AWE, while the control group consisted of 17 patients who had undergone laparotomy without any history of endometriosis. We analyzed clinical characteristics and examined the innervation patterns in samples using stains for S-100, neuron-specific enolase (NSE), protein gene product 9.5 (PGP9.5), neurofilament (NF), and substance P (SP) antibodies.Results: There was a notable increase in the density of S-100, NSE and PGP9.5 immunoreactive nerve fibers and a higher proportion of SP positivity in AWE lesions compared to standard abdominal wall scars (p < 0.05). However, there were no significant differences in the density or proportion of NF-immunoreactive nerve fibers between the cases and the controls. Moreover, no statistically significant correlation was observed between the density of S-100, NSE, PGP9.5, NF, or SP-positive nerve fibers and pain scores.Conclusion: This study demonstrated an increased immunoreactive nerve fiber density located in AWE lesions compared to normal abdominal wall scars. Further high-quality studies are needed to investigate the mechanisms responsible for pain in women with endometriosis.Keywords: abdominal wall endometriosis, pain, nerve fibers, immunohistochemistry
Full text 2,375 characters · extracted from oa-html · click to expand
Journal of Pain Research (Apr 2024) Distribution of Nerve Fibers in Abdominal Wall Endometriosis and Their Clinical Significance Abstract Chenyu Zhang,1 Yi Dai,1 Junji Zhang,1 Xiaoyan Li,1 Shuangzheng Jia,2 Jinghua Shi,1,* Jinhua Leng1,* 1Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, People’s Republic of China; 2Department of Gynecologic Oncology, National Cancer Center / National Clinical Research Center for Cancer / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinghua Shi; Jinhua Leng, Tel +86 151-0101-6294 ; +86 137-0129-8616, Email [email protected]; [email protected]: This study aimed to explore the distribution of nerve fibers in abdominal wall endometriosis (AWE) and discern their association with pain.Methods: A retrospective case–control study was conducted. The cases comprised 30 patients diagnosed with AWE, while the control group consisted of 17 patients who had undergone laparotomy without any history of endometriosis. We analyzed clinical characteristics and examined the innervation patterns in samples using stains for S-100, neuron-specific enolase (NSE), protein gene product 9.5 (PGP9.5), neurofilament (NF), and substance P (SP) antibodies.Results: There was a notable increase in the density of S-100, NSE and PGP9.5 immunoreactive nerve fibers and a higher proportion of SP positivity in AWE lesions compared to standard abdominal wall scars (p < 0.05). However, there were no significant differences in the density or proportion of NF-immunoreactive nerve fibers between the cases and the controls. Moreover, no statistically significant correlation was observed between the density of S-100, NSE, PGP9.5, NF, or SP-positive nerve fibers and pain scores.Conclusion: This study demonstrated an increased immunoreactive nerve fiber density located in AWE lesions compared to normal abdominal wall scars. Further high-quality studies are needed to investigate the mechanisms responsible for pain in women with endometriosis.Keywords: abdominal wall endometriosis, pain, nerve fibers, immunohistochemistry

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2024) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

openalex
last seen: 2026-05-14T06:11:13.535169+00:00
License: CC0 · commercial use OK