Impact of Excessive Postural Tachycardia on Disability in Youth with Orthostatic Intolerance

Impact of Excessive Postural Tachycardia on Disability in Youth with Orthostatic Intolerance | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Impact of Excessive Postural Tachycardia on Disability in Youth with Orthostatic Intolerance Kirti Sivakoti, Olivia Parnell, Corinne Espinoza, Casey Tak, Philip Fischer, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6875022/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Purpose: Adolescents with chronic orthostatic intolerance (COI) experience symptoms related to impaired tolerance of upright posture. Postural Orthostatic Tachycardia Syndrome (POTS) is a specific type of COI, marked by an excessive increase in heart rate (≥40 bpm or an absolute HR >120 bpm) when standing. This study compares Functional Disability Inventory (FDI) scores between adolescents with COI with and without excessive postural tachycardia (POTS subtype). Methods: Patients ≤19 years referred to our POTS program (Aug 2024–Mar 2025) with orthostatic symptoms for>3 months were included. Based on active stand HR, patients were categorized as POTS (HR ≥40 bpm) or COI without excessive postural tachycardia (HR <40 bpm). FDI scores were collected. Chi-square tests assessed group differences. A two-sample t-test compared FDI severity. Linear regression evaluated the association between HR change and FDI score. Results: All data were normally distributed, allowing the use of parametric analyses. Of the 92 patients (46 per group), 78% were female. The mean age was 16.0 ± 1.48 years in the COI group and 16.3 ± 1.7 years in the POTS group, with no significant sex differences between groups. The COI group had a higher mean FDI score than the POTS group, but this difference was not statistically significant. The distribution of FDI severity (mild, moderate, severe) was similar between groups. Linear regression showed a non-significant trend of a 1 bpm increase in heart rate associated with a 0.1055-point decrease in FDI score Conclusion: Functional disability was similar between the COI and POTS groups. Adolescent Dysautonomia Postural Tachycardia Diagnosis Orthostatic Intolerance Functional Disability POTS Full Text Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6875022","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":472667380,"identity":"e957a9a4-7417-4c2e-960a-33247427870c","order_by":0,"name":"Kirti 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22:06:05","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6875022/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6875022/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":92422613,"identity":"5028f031-536f-40de-a0a3-cf4f87ea6419","added_by":"auto","created_at":"2025-09-29 14:39:23","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":411154,"visible":true,"origin":"","legend":"","description":"","filename":"ImpactexcessivetachycardiaSivakoti6.3.2025.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6875022/v1_covered_193c2908-4668-4711-af39-42cd36d6217c.pdf"}],"financialInterests":"","formattedTitle":"Impact of Excessive Postural Tachycardia on Disability in Youth with Orthostatic 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Disability, POTS ","lastPublishedDoi":"10.21203/rs.3.rs-6875022/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6875022/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003ePurpose: Adolescents with chronic orthostatic intolerance (COI) experience symptoms related to\u0026nbsp; impaired tolerance of upright posture. Postural Orthostatic Tachycardia Syndrome (POTS) is a specific type of COI, marked by an excessive increase in heart rate (≥40 bpm or an absolute HR\u0026nbsp; \u0026gt;120 bpm) when standing. This study compares Functional Disability Inventory (FDI) scores between adolescents with COI with and without excessive postural tachycardia (POTS subtype).\u003c/p\u003e\n\u003cp\u003eMethods:\u0026nbsp; Patients ≤19 years referred to our POTS program (Aug 2024–Mar 2025) with orthostatic\u0026nbsp; symptoms for\u0026gt;3 months were included. Based on active stand HR, patients were categorized as POTS (HR ≥40 bpm) or COI without excessive postural tachycardia (HR \u0026lt;40 bpm). FDI scores were collected. Chi-square tests assessed group differences. A two-sample t-test compared FDI severity. Linear regression evaluated the association between HR change and FDI score.\u003c/p\u003e\n\u003cp\u003eResults:\u0026nbsp; All data were normally distributed, allowing the use of parametric analyses. Of the 92 patients\u0026nbsp; (46 per group), 78% were female. The mean age was 16.0 ± 1.48 years in the COI group and 16.3 ± 1.7 years in the POTS group, with no significant sex differences between groups. The COI group had a higher mean FDI score than the POTS group, but this difference was not statistically significant. The distribution of FDI severity (mild, moderate, severe) was similar between groups. Linear regression showed a non-significant trend of a 1 bpm increase in heart rate associated with a 0.1055-point decrease in FDI score\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eConclusion: Functional disability was similar between the COI and POTS groups.\u003c/p\u003e","manuscriptTitle":"Impact of Excessive Postural Tachycardia on Disability in Youth with Orthostatic Intolerance","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-06-19 21:48:15","doi":"10.21203/rs.3.rs-6875022/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"c4b586d8-31bc-4354-a210-b71ea9972379","owner":[],"postedDate":"June 19th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-09-29T14:31:15+00:00","versionOfRecord":[],"versionCreatedAt":"2025-06-19 21:48:15","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6875022","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6875022","identity":"rs-6875022","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}