Renal Parenchyma Preservation in Giant Bilateral Wilms Tumor Following Multistage Chemotherapy and Staged Surgery Based on the SIOP Protocol: A Rare Pediatric Case Report

Renal Parenchyma Preservation in Giant Bilateral Wilms Tumor Following Multistage Chemotherapy and Staged Surgery Based on the SIOP Protocol: A Rare Pediatric Case Report | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 1 August 2025 V1 Latest version Share on Renal Parenchyma Preservation in Giant Bilateral Wilms Tumor Following Multistage Chemotherapy and Staged Surgery Based on the SIOP Protocol: A Rare Pediatric Case Report Authors : Ramin Malikov 0009-0009-2858-9383 [email protected] , Gambar Ismayilov , and Iqbal Babazade Authors Info & Affiliations https://doi.org/10.22541/au.175404613.33523168/v1 259 views 160 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Wilms tumor (WT) (nephroblastoma) is the most common malignant renal tumor in children, and in approximately 5–7% of cases, it presents bilaterally. In such cases, the treatment approach aims to ensure both oncologic effectiveness and maximal preservation of functional renal tissue. This report describes a 16-month-old, non-syndromic child with a giant Bilateral Wilms tumor (BWT). The patient was treated with staged chemotherapy according to the SIOP-2016 protocol; however, no significant reduction in tumor size was observed. Due to the right kidney contributing only 1% to total renal function, a total nephrectomy (NK) was performed in the first stage, followed by a successful partial nephrectomy (nephron-sparing surgery) (NSS) of the left kidney. Histopathological evaluation confirmed a biphasic histological type with a predominance of the mesenchymal component. Although this condition is rare, it demonstrates that, with a multidisciplinary approach and a personalized treatment strategy, it is possible to preserve functional renal parenchyma and avoid the need for transplantation. Chemotherapy based on the SIOP-2016 protocol proved effective in terms of histological response and had a positive impact on the long-term outcomes of treatment. Supplementary Material File (bwt case report eng.docx) Download 33.24 KB File (figures-1,figures-2,figures-3.zip) Download 44.97 MB Information & Authors Information Version history V1 Version 1 01 August 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords chemotherapy drug resistance general hematology/oncology nephrology oncology pathology pediatric oncology rare tumors surgery wilms tumor Authors Affiliations Ramin Malikov 0009-0009-2858-9383 [email protected] National Center of Oncology View all articles by this author Gambar Ismayilov National Center of Oncology View all articles by this author Iqbal Babazade Azerbaijan Medical University View all articles by this author Metrics & Citations Metrics Article Usage 259 views 160 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Ramin Malikov, Gambar Ismayilov, Iqbal Babazade. Renal Parenchyma Preservation in Giant Bilateral Wilms Tumor Following Multistage Chemotherapy and Staged Surgery Based on the SIOP Protocol: A Rare Pediatric Case Report. Authorea . 01 August 2025. DOI: https://doi.org/10.22541/au.175404613.33523168/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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