Depicting the innate immune response landscape in Covid-19 emphasized type 1 interferon a key defense against SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been rampantly threatening much more people life, thus timely and precise countermeasures against SARS-COV-2 were a matter of urgency. Here, integrated bio-information analyse were used for deeply understanding the process of SARS-COV-2 infection. And it was demonstrated that pathways related to antivirus response, innate immune response, and type 1 interferon pathways were dominantly enriched in Covid-19, while neutrophil degranulation, inflammatory reaction and Covid-19 adverse outcome were also assigned significance. PPI network revealed that type 1 interferon pathways related genes ranked as the hub genes in Covid-19, and among these genes OASL, IFIT1,IFIT2,IFIT3 might be typically drug targeted, which was demonstrated by the cerna network and drug interaction network. Our research in the end meant to fundamentally achieve recommended strategies to benefit people suffering from SARS-COV-2 infection.