The Quantitative Evaluation of Retinal Layers After Resolution of Subretinal Fluid in Acute Central Serous Chorioretinopathy

Purpose: To evaluate the average retinal layer thicknesses in eyes with unilateral acute central serous chorioretinopathy (CSC) (with subretinal fluid (SRF)) and after complete resolution of SRF in these eyes and to compare the results with those obtained in healthy eyes. Methods: : Fifty-four eyes of 27 patients with unilateral acute CSC who had complete resolution of SRF and 25 eyes of 25 healthy control subjects enrolled in this retrospective study. The average thicknesses of the retinal layers were measured by segmentation analysis of optical coherence tomography at baseline and 6 months after complete resolution of SRF. Results: : The mean outer nuclear layer (ONL) thickness was significantly lower in eyes with CSC than in fellow eyes (p0.05). There were significant correlations between visual acuity and ONL thicknesses at baseline and 6 months after complete resolution of SRF (p<0.001, r=-0.810; p<0.001, r=-0.705, respectively). Conclusion: ONL thickness is thinned in cases with acute CSC, and although there is some increment in ONL thickness 6 months after complete resolution of SRF, it is still thinner compared to unaffected fellow eyes.