PGE2-mediated MMP-2 activity promotes angiogenesis in endometriosis.

Sayantan Jana (3190551), Kasturi Chatterjee (3190545), Amlan K. Ray (3190548), Pramathes DasMahapatra (3190542), Snehasikta Swarnakar (232461)
2016 · doi:10.1371/journal.pone.0163540.g009 · W6885711231
other OA: green CC0
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Abstract

Endometriosis is an inflammatory, proliferative disease with increased PGE2 responses. The production of PGE2 from arachidonic acid (A.A.) is regulated by cycloxygenase-2 (COX-2). The present study found that the COX-2-PGE2-pAKT axis is involved in regulation of MMP-2 activity in endothelial cells which in turn promote angiogenesis in endometriosis.

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endometriosis

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last seen: 2026-05-11T08:36:13.228947+00:00
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