Joint Modeling of Hypertension Measurements and Time-to-Onset of Preeclampsia Among Pregnant Women Attending Antenatal Care Service at Arerti Primary Hospital, North Shoa, Ethiopia

Joint Modeling of Hypertension Measurements and Time-to-Onset of Preeclampsia Among Pregnant Women Attending Antenatal Care Service at Arerti Primary Hospital, North Shoa, Ethiopia | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Help Center Sign In Submit a Preprint Cite Share Download PDF Research Joint Modeling of Hypertension Measurements and Time-to-Onset of Preeclampsia Among Pregnant Women Attending Antenatal Care Service at Arerti Primary Hospital, North Shoa, Ethiopia Dawit Baye Haile, Aragaw Eshetie Aguade, Moges Zerihun Fetene This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-127844/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Preeclampsia is a hypertensive disorder of pregnancy that affects 2-8% of pregnant women. It is the major cause of maternal and perinatal morbidity and mortality worldwide. The purpose of this study was to identify factors associated with hypertension measurements and time-to-onset of preeclampsia among pregnant women attending antenatal care service at Arerti Primary Hospital. Methodology: A retrospective longitudinal study design was employed on a total of 201 pregnant women attending the antenatal clinic of Arerti Primary Hospital between September 2018 and June 2019. A closed-form sample size formula for estimating the effect of the longitudinal data on time-to-event was used. To analyze our data we employed descriptive method, linear mixed effect model, Cox-PH model and joint models for longitudinal and survival outcomes.Relevantdemographicandclinicalcovariateswereincludedinsubmodels. Results: This study revealed that baseline age, visiting times, weight, diabetes, history of PE and parity had significantly associated with mean change in the BP measurements. From the Cox model result, age, weight, history of PE and marital status were associated with a significant hazard of developing preeclampsia. The univariate joint models reveal that the each longitudinal BP measurements are significantly associated with hazard of developing preeclampsia. Form the bi-ariate joint model; only DBP is significantly associated with risk of developing PE. Conclusion: As the result obtained in this study, we summarized that, age, weight, history of PE and marital status had a significant effect on time to developing preeclampsia. Furthermore, due to significance of association between the longitudinal BP measurements and time to onset of preeclampsia, joint model analysis was suggested as it incorporates all information simultaneously and provides valid and efficient inferences over separate models analysis. Sexual & Reproductive Medicine Bi-variate joint model Diastolic Blood Pressure Longitudinal sub-model Systolic BloodPressure Survivalsub-model Timetoonsetofpreeclampsia univariatejointmodel Full Text Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the latest manuscript can be downloaded and accessed as a PDF. Supplementary Files Suportinginformation.pdf Suportinginformation.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-127844","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research","associatedPublications":[],"authors":[{"id":6370827,"identity":"4c6e2c77-90af-44f6-b7d2-011260f789d2","order_by":0,"name":"Dawit Baye Haile","email":"","orcid":"","institution":"Dilla University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Dawit","middleName":"Baye","lastName":"Haile","suffix":""},{"id":6370828,"identity":"73499d8d-f98f-46a4-9574-8dda3e1f06ec","order_by":1,"name":"Aragaw Eshetie Aguade","email":"","orcid":"","institution":"University of Gondar","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Aragaw","middleName":"Eshetie","lastName":"Aguade","suffix":""},{"id":6370829,"identity":"071efce5-8f99-4e4e-9736-08264b252f9b","order_by":2,"name":"Moges Zerihun Fetene","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA6klEQVRIiWNgGAWjYBACCWYGAwaGAxJAgoHxAZDg4SNFCzOI4GEjqIUBrAVEMLBJgEQIapFsZ974ueCMhTG/dPOxyq85djJsDMwPH93Ao0Wama1YesYNCTPJOcfSbstuSwY6jM3YOAePFjlmHgNpng8SNgY3csxuS25jBmrhYZMmoMX4N0RL/rdiyW31hLVIM/OYSfMAHQa0hY3x47bDhLVINrOVWfOckTCWnJFmLM247TgPGzMBv0icP7z5Ns+xOsN+ieSHH39uq7bnZ29++BifFhTAzAMmiVUOAow/SFE9CkbBKBgFIwYAAJRSPmtpBurlAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0002-1466-9683","institution":"University of Gondar","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Moges","middleName":"Zerihun","lastName":"Fetene","suffix":""}],"badges":[],"createdAt":"2020-12-13 18:41:28","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-127844/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-127844/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":13631981,"identity":"3eb0e440-d88c-4877-a628-1d9f0c4a1c5a","added_by":"auto","created_at":"2021-09-17 08:19:11","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":144604,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-127844/v1/470406e4-9a39-46ee-ac4a-7c2e5e74dbd1.pdf"},{"id":4282329,"identity":"4751899a-bdf5-43aa-8476-047d8010a9a0","added_by":"auto","created_at":"2020-12-15 19:47:38","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":294044,"visible":true,"origin":"","legend":"","description":"","filename":"Suportinginformation.pdf","url":"https://assets-eu.researchsquare.com/files/rs-127844/v1/bc0e5c3dd8a3c4e3481f20d3.pdf"},{"id":4282325,"identity":"0c9351f2-3e64-4fda-8c6a-a9ebd154ec15","added_by":"auto","created_at":"2020-12-15 19:47:32","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":294044,"visible":true,"origin":"","legend":"","description":"","filename":"Suportinginformation.pdf","url":"https://assets-eu.researchsquare.com/files/rs-127844/v1/c7ae8968f25978e875a7a585.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003eJoint Modeling of Hypertension Measurements and Time-to-Onset of Preeclampsia Among Pregnant Women Attending Antenatal Care Service at Arerti Primary Hospital, North Shoa, Ethiopia\u003c/p\u003e","fulltext":[{"header":"Full Text","content":"Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. 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It is the major cause of maternal and perinatal morbidity and mortality worldwide. The purpose of this study was to identify factors associated with hypertension measurements and time-to-onset of preeclampsia among pregnant women attending antenatal care service at Arerti Primary Hospital. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethodology:\u003c/strong\u003e A retrospective longitudinal study design was employed on a total of 201 pregnant women attending the antenatal clinic of Arerti Primary Hospital between September 2018 and June 2019. A closed-form sample size formula for estimating the effect of the longitudinal data on time-to-event was used. To analyze our data we employed descriptive method, linear mixed effect model, Cox-PH model and joint models for longitudinal and survival outcomes.Relevantdemographicandclinicalcovariateswereincludedinsubmodels. 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Furthermore, due to significance of association between the longitudinal BP measurements and time to onset of preeclampsia, joint model analysis was suggested as it incorporates all information simultaneously and provides valid and efficient inferences over separate models analysis.\u003c/p\u003e","manuscriptTitle":"Joint Modeling of Hypertension Measurements and Time-to-Onset of Preeclampsia Among Pregnant Women Attending Antenatal Care Service at Arerti Primary Hospital, North Shoa, Ethiopia","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2020-12-15 19:47:31","doi":"10.21203/rs.3.rs-127844/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"83c0d643-0e1d-44aa-bd5d-ad60e317119a","owner":[],"postedDate":"December 15th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":1480966,"name":"Sexual \u0026 Reproductive Medicine"}],"tags":[],"updatedAt":"2020-12-15T19:47:32+00:00","versionOfRecord":[],"versionCreatedAt":"2020-12-15 19:47:31","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-127844","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-127844","identity":"rs-127844","version":["v1"]},"buildId":"369fNeqWncA4NS6XSWjrt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}