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This multi-institutional study evaluated the prognostic significance of Emi1 and Galectin-3 expression in 129 cases of pure ovarian clear cell carcinoma. The researchers analyzed immunohistochemical markers alongside clinicopathologic parameters to determine their association with survival outcomes in patients with a mean age of 49.6 years. High Emi1 expression was significantly associated with higher FIGO grades and poorer overall survival, while high Galectin-3 levels correlated with advanced disease stages and increased proliferation indices. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.
Abstract
Accurate diagnosis of ovarian clear cell carcinoma (CCC) is important because of its poor prognosis with chemoresistance and a high recurrent rate. The clinicopathologic characteristics and prognostic significance of the cell cycle regulator [early mitotic inhibitor-1 (Emi1)] and galactoside-binding protein (Galectin-3) were evaluated. Among 155 CCCs from 18 hospitals in Korea between 1995 and 2006, 129 pure CCCs were selected with consensus using immunohistochemical stains for hepatocyte nuclear factor-1β, Wilms' tumor protein, and estrogen receptor. The expressions of Emi1, Galectin-3, p53, and Ki-67 labeling index were analyzed with clinicopathologic parameters and the patient's survival. The mean age of the patients was 49.6 yr; the tumors were bilateral in 10.9%, and the average size was 12 cm. Adenofibromatous component was found in 7%, and endometriosis in 48.1% of the cases. Psammoma body was seen in 16.3%. Disease-free survival and overall survival rates were 78.3% and 79.1%, respectively. The International Federation of Obstetrics and Gynecology (FIGO) stage was the most important prognostic indicator. Emi1 expression (>5%) was seen in 23.3% of CCCs, and associated with high FIGO grades and poor overall survival (P<0.05). High Galectin-3 (≥80%) expression was seen in 59.7% of CCCs, and associated with FIGO stages III and IV, and high Ki-67 labeling index. High Ki-67 labeling index (≥50%) and p53 expression (≥50%) were seen in 27.1% and 18.6% of CCCs, respectively, but there was no clinicopathologic and prognostic significance. On the basis of the fact that the expression of Emi1 in CCC was correlated with a high histologic grade and worse overall survival, target therapy using inhibitors of Emi1 may be tried in the management of CCC patients with Emi1 expression.
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- Keimyung Author(s)
- Kwon, Sun Young
- Department
- Dept. of Pathology (병리학)
- Journal Title
- International Journal of Gynecological Pathology
- Issued Date
- 2013
- Volume
- 32
- Issue
- 1
- Abstract
- Accurate diagnosis of ovarian clear cell carcinoma (CCC) is important because of its poor prognosis with chemoresistance and a high recurrent rate. The clinicopathologic characteristics and prognostic significance of the cell cycle regulator [early mitotic inhibitor-1 (Emi1)] and galactoside-binding protein (Galectin-3) were evaluated. Among 155 CCCs from 18 hospitals in Korea between 1995 and 2006, 129 pure CCCs were selected with consensus using immunohistochemical stains for hepatocyte nuclear factor-1[beta], Wilms' tumor protein, and estrogen receptor. The expressions of Emi1, Galectin-3, p53, and Ki-67 labeling index were analyzed with clinicopathologic parameters and the patient’s survival. The mean age of the patients was 49.6 yr; the tumors were bilateral in 10.9%, and the average size was 12 cm. Adenofibromatous component was found in 7%, and endometriosis in 48.1% of the cases. Psammoma body was seen in 16.3%. Disease-free survival and overall survival rates were 78.3% and 79.1%, respectively. The International Federation of Obstetrics and Gynecology (FIGO) stage was the most important prognostic indicator. Emi1 expression (>5%) was seen in 23.3% of CCCs, and associated with high FIGO grades and poor overall survival (P=80%) expression was seen in 59.7% of CCCs, and associated with FIGO stages III and IV, and high Ki-67 labeling index. High Ki-67 labeling index (>=50%) and p53 expression (>=50%) were seen in 27.1% and 18.6% of CCCs, respectively, but there was no clinicopathologic and prognostic significance. On the basis of the fact that the expression of Emi1 in CCC was correlated with a high histologic grade and worse overall survival, target therapy using inhibitors of Emi1 may be tried in the management of CCC patients with Emi1 expression
- Keimyung Author(s)(Kor)
- 권선영
- Publisher
- School of Medicine
- Citation
- Kyueng-Whan Min et al. (2013). Clear Cell Carcinomas of the Ovary: A Multi-Institutional
Study of 129 Cases in Korea With Prognostic Significance
of Emi1 and Galectin-3. International Journal of Gynecological Pathology, 32(1), 3–14. doi: 10.1097/PGP.0b013e31825554e9
- Type
- Article
- ISSN
- 0277-1691
- Source
- http://lps3.insights.ovid.com.proxy.dsmc.or.kr/pubmed?pmid=23202783
- Appears in Collections:
- 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
- Files in This Item:
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MeSH descriptors
Adenocarcinoma, Clear Cell
Biomarkers, Tumor
Cell Cycle Proteins
F-Box Proteins
Galectin 3
Ovarian Neoplasms
Adenocarcinoma, Clear Cell
Adenocarcinoma, Clear Cell
Adenocarcinoma, Clear Cell
Adult
Aged
Biomarkers, Tumor
Cell Cycle Proteins
Cell Cycle Proteins
Disease-Free Survival
F-Box Proteins
F-Box Proteins
Female
Galectin 3
Galectin 3