Pengaruh pembilasan cairan endometrioma terhadap kadar transforming growth factor-ß1 dan skor adhesi klinis

Sonia Rahayu, Relly Yanuari Primariawan, D Hendy Hendarto, Lila D. Azinar, Widjiati Widjiati
2013 · W1906082476
article OA: green CC0
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Ten saline washes after endometrioma fluid removal during laparoscopy in rabbits significantly reduced peritoneal TGF-ß1 and clinical adhesion scores compared to suction or fewer washes.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This paper investigated the effect of washing endometrioma fluid on transforming growth factor-β1 levels and on clinical adhesion scores, using a study design described in an obstetrics and gynecology journal article (Majalah Obstetri & Ginekologi, Vol. 21 No. 1, 2013, pp. 7–15). The reviewers’ assessment forms indicate that the evaluated work received scores for journal elements, scope/depth of discussion, adequacy/recency of data and methodology, and publisher quality, with notes focusing on those components rather than providing detailed results in the text provided here. A limitation explicitly evident from the materials shared is that the full study methods and findings are not included in the excerpt, so the specific direction or magnitude of TGF-β1 changes and adhesion-score effects cannot be extracted. This paper is centrally about endometriosis — it specifically examines how endometrioma irrigation influences transforming growth factor-β1 and clinical adhesion scores.

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Abstract

Endometrioma adalah salah satu jenis kista ovarium yang berisi cairan kecoklatan sebagai akumulasi darah menyerupai perdarahan menstruasi di dalam kista. Pembilasan adalah metode yang umum dikerjakan guna menghilangkan cairan endometrioma. Penelitian ini bertujuan memberikan gambaran efektifitas pembilasan untuk menurunkan resiko perlekatan melalui evaluasi peran TGF-b1 sebagai mediator utama terjadinya perlekatan pasca pembedahan. Pada penelitian ini dibagi grup Orictologus cuniculus secara random menjadi empat grup laparoskopik: [1] pembilasan cairan endometrioma manusia, suction; [2] pembilasan cairan endometrioma manusia, pembilasan salin; [3] pembilasan cairan endometrioma manusia, pembilasan salin sebanyak sepuluh kali; [4] hanya laparoskopi. Pada hari ke-14 konsentrasi TGF-b1 jaringan peritoneal dievaluasi menggunakan prosedur ELISA dan skor adhesi menggunakan sistem skoring standar. Konsentrasi TGF-b1 dianalisa menggunakan ANOVA dan uji tes Mann-Whitney untuk skor adhesi klinis. Berdasarkan hasil statistik, Group 1 memiliki konsentrasi TGF-b1 jaringan peritoneal yang signifikan lebih tinggi (p = 0,001) dan skor adhesi klinis (p = 0,021) dibandingkan dengan kelompok 3. Pada group 2 konsentrasi TGF-b1 jaringan peritoneal signifikan lebih tinggi dibanding grup 3 (p=.004), akan tetapi skor adhesi klinis tidak signifikan secara statistik dibandingkan dengan grup 3 (p = 0,328) dan 1 (p = 0,195). Kesimpulan, pada pembedahan laparoskopik menggunakan model kelinci, efek pembilasan dengan salin sebanyak sepuluh kali bisa mengurangi konsentrasi TGF-b1 jaringan peritoneal dan mean skor adhesi klinis. (MOG 2013;21:7-15)

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endometrioma

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